CA3036349C - Compose cyclique presentant une activite inhibitrice du recepteur de type toll 4 (tlr 4) - Google Patents

Compose cyclique presentant une activite inhibitrice du recepteur de type toll 4 (tlr 4)

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Publication number
CA3036349C
CA3036349C CA3036349A CA3036349A CA3036349C CA 3036349 C CA3036349 C CA 3036349C CA 3036349 A CA3036349 A CA 3036349A CA 3036349 A CA3036349 A CA 3036349A CA 3036349 C CA3036349 C CA 3036349C
Authority
CA
Canada
Prior art keywords
compound
drugs
present
chemotherapy
hydrochloride
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3036349A
Other languages
English (en)
Other versions
CA3036349A1 (fr
Inventor
Toshitake Kobayashi
Morihisa Saitoh
Yasufumi Wada
Nobuyuki Negoro
Masashi Yamasaki
Takahiro Tanaka
Naomi Kitamoto
Original Assignee
Takeda Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical Co Ltd filed Critical Takeda Pharmaceutical Co Ltd
Priority claimed from PCT/JP2017/032192 external-priority patent/WO2018047888A1/fr
Publication of CA3036349A1 publication Critical patent/CA3036349A1/fr
Application granted granted Critical
Publication of CA3036349C publication Critical patent/CA3036349C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Abstract

La présente invention concerne un composé qui a une action d’inhibition de signal du récepteur Toll 4 (TLR4) exceptionnelle, qui peut être utilisé en tant que médicament prophylactique ou thérapeutique contre des maladies telles que des maladies auto-immunes et/ou des maladies inflammatoires, ou des maladies telles que la neuropathie périphérique induite par la chimiothérapie, une douleur neuropathique induite par une chimiothérapie, des troubles hépatiques et une lésion de reperfusion ischémique. La présente invention concerne le composé éthyl 6-((2-chloro-4-fluorobenzyl)sulfonyl)-3-hydroxycyclohex-l-ene-l-carboxylate ou un isomère optique de celui-ci.
CA3036349A 2016-09-09 2017-09-07 Compose cyclique presentant une activite inhibitrice du recepteur de type toll 4 (tlr 4) Active CA3036349C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2016-176545 2016-09-09
JP2016176545 2016-09-09
PCT/JP2017/032192 WO2018047888A1 (fr) 2016-09-09 2017-09-07 Composé cyclique

Publications (2)

Publication Number Publication Date
CA3036349A1 CA3036349A1 (fr) 2018-03-15
CA3036349C true CA3036349C (fr) 2026-01-20

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