CA3036358C - Derives de pyrazolopyridine comme modulateurs de hpk1 et leurs utilisations pour le traitement du cancer - Google Patents

Derives de pyrazolopyridine comme modulateurs de hpk1 et leurs utilisations pour le traitement du cancer

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Publication number
CA3036358C
CA3036358C CA3036358A CA3036358A CA3036358C CA 3036358 C CA3036358 C CA 3036358C CA 3036358 A CA3036358 A CA 3036358A CA 3036358 A CA3036358 A CA 3036358A CA 3036358 C CA3036358 C CA 3036358C
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CA
Canada
Prior art keywords
independently selected
alkyl
cycloalkyl
pyridin
alkenyl
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Active
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CA3036358A
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English (en)
Other versions
CA3036358A1 (fr
Inventor
Hai-Fen Ye
Oleg Vechorkin
Jun Pan
Kai Liu
Alexander Sokolsky
Anlai Wang
Qinda Ye
Wenqing Yao
Original Assignee
Incyte Corp
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Priority claimed from PCT/US2017/050737 external-priority patent/WO2018049200A1/fr
Publication of CA3036358A1 publication Critical patent/CA3036358A1/fr
Application granted granted Critical
Publication of CA3036358C publication Critical patent/CA3036358C/fr
Active legal-status Critical Current
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Abstract

L'invention concerne des composés de formule (I), des méthodes d'utilisation de ces composés pour inhibier l'activité de HPK1, et des compositions pharmaceutiques comprenant de tels composés. Les composés sont utiles dans le traitement, la prévention ou le soulagement de maladies ou de troubles associés à l'activité de HPK1, tels que le cancer.
CA3036358A 2016-09-09 2017-09-08 Derives de pyrazolopyridine comme modulateurs de hpk1 et leurs utilisations pour le traitement du cancer Active CA3036358C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662385584P 2016-09-09 2016-09-09
US62/385,584 2016-09-09
PCT/US2017/050737 WO2018049200A1 (fr) 2016-09-09 2017-09-08 Dérivés de pyrazolopyridine comme modulateurs de hpk1 et leurs utilisations pour le traitement du cancer

Publications (2)

Publication Number Publication Date
CA3036358A1 CA3036358A1 (fr) 2018-03-15
CA3036358C true CA3036358C (fr) 2025-10-07

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