CA3038624C - Derives naphthyridinone et leur utilisation dans le traitement de l'arrhythmie - Google Patents

Derives naphthyridinone et leur utilisation dans le traitement de l'arrhythmie

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Publication number
CA3038624C
CA3038624C CA3038624A CA3038624A CA3038624C CA 3038624 C CA3038624 C CA 3038624C CA 3038624 A CA3038624 A CA 3038624A CA 3038624 A CA3038624 A CA 3038624A CA 3038624 C CA3038624 C CA 3038624C
Authority
CA
Canada
Prior art keywords
naphthyridin
chloro
dichlorophenyl
methyl
hydroxymethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3038624A
Other languages
English (en)
Other versions
CA3038624A1 (fr
Inventor
Guillaume Barbe
Gregory Raymond Bebernitz
Sicong GENG
Hatice Belgin GULGEZE EFTHYMIOU
Lv LIAO
Fupeng Ma
Ruowei MO
David Thomas Parker
Yunshan Peng
Stefan Peukert
Ken Yamada
Kayo Yasoshima
Nicola Smith
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Priority claimed from PCT/IB2017/056515 external-priority patent/WO2018073788A1/fr
Publication of CA3038624A1 publication Critical patent/CA3038624A1/fr
Application granted granted Critical
Publication of CA3038624C publication Critical patent/CA3038624C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Abstract

La présente invention concerne un composé de formule (I), ou un sel pharmaceutiquement acceptable associé, dans laquelle formule (I) R1, R3-R6, X2 et X3 sont tels que définis dans la description, un procédé de fabrication des composés de l'invention, et leurs utilisations thérapeutiques. Cette invention concerne en outre une association de principes pharmacologiquement actifs et une composition pharmaceutique.
CA3038624A 2016-10-21 2017-10-19 Derives naphthyridinone et leur utilisation dans le traitement de l'arrhythmie Active CA3038624C (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662410930P 2016-10-21 2016-10-21
CN2016102928 2016-10-21
CNPCT/CN2016/102928 2016-10-21
US62/410,930 2016-10-21
US201662413292P 2016-10-26 2016-10-26
US62/413,292 2016-10-26
PCT/IB2017/056515 WO2018073788A1 (fr) 2016-10-21 2017-10-19 Dérivés naphthyridinone et leur utilisation dans le traitement de l'arrhythmie

Publications (2)

Publication Number Publication Date
CA3038624A1 CA3038624A1 (fr) 2018-04-26
CA3038624C true CA3038624C (fr) 2025-09-23

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