CA3039368C - Activateurs d'ampk a petites molecules - Google Patents

Activateurs d'ampk a petites molecules

Info

Publication number
CA3039368C
CA3039368C CA3039368A CA3039368A CA3039368C CA 3039368 C CA3039368 C CA 3039368C CA 3039368 A CA3039368 A CA 3039368A CA 3039368 A CA3039368 A CA 3039368A CA 3039368 C CA3039368 C CA 3039368C
Authority
CA
Canada
Prior art keywords
substituted
compound
pharmaceutically acceptable
stereoisomer
ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3039368A
Other languages
English (en)
Other versions
CA3039368A1 (fr
Inventor
Beibei Chen
Rama K. Mallampalli
Yuan Liu
Original Assignee
University of Pittsburgh
US Department of Veterans Affairs
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Pittsburgh, US Department of Veterans Affairs filed Critical University of Pittsburgh
Priority claimed from PCT/US2017/055109 external-priority patent/WO2018067685A1/fr
Publication of CA3039368A1 publication Critical patent/CA3039368A1/fr
Application granted granted Critical
Publication of CA3039368C publication Critical patent/CA3039368C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Abstract

Il est décrit des composés qui perturbent l'interaction entre Fbxo48 et la protéine kinase de peptide antimicrobien phosphorylée utiles pour le traitement de troubles inflammatoires, de sepsie, de blessure pulmonaire accrue et du syndrome métabolique.
CA3039368A 2016-10-05 2017-10-04 Activateurs d'ampk a petites molecules Active CA3039368C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662404592P 2016-10-05 2016-10-05
US62/404,592 2016-10-05
PCT/US2017/055109 WO2018067685A1 (fr) 2016-10-05 2017-10-04 Activateurs d'ampk à petites molécules

Publications (2)

Publication Number Publication Date
CA3039368A1 CA3039368A1 (fr) 2018-04-12
CA3039368C true CA3039368C (fr) 2025-10-07

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