CA3046864C - Inhibiteur de cdk4/6 - Google Patents

Inhibiteur de cdk4/6

Info

Publication number
CA3046864C
CA3046864C CA3046864A CA3046864A CA3046864C CA 3046864 C CA3046864 C CA 3046864C CA 3046864 A CA3046864 A CA 3046864A CA 3046864 A CA3046864 A CA 3046864A CA 3046864 C CA3046864 C CA 3046864C
Authority
CA
Canada
Prior art keywords
compound
group
pharmaceutically acceptable
reaction
acceptable salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3046864A
Other languages
English (en)
Other versions
CA3046864A1 (fr
Inventor
Zhaobing Xu
Lihong Hu
Charles Z. Ding
Shuhui Chen
Original Assignee
CStone Pharmaceuticals Shanghai Co Ltd
CStone Pharmaceuticals Suzhou Co Ltd
CStone Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CStone Pharmaceuticals Shanghai Co Ltd, CStone Pharmaceuticals Suzhou Co Ltd, CStone Pharmaceuticals filed Critical CStone Pharmaceuticals Shanghai Co Ltd
Priority claimed from PCT/CN2017/116611 external-priority patent/WO2018108167A1/fr
Publication of CA3046864A1 publication Critical patent/CA3046864A1/fr
Application granted granted Critical
Publication of CA3046864C publication Critical patent/CA3046864C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Abstract

L'invention concerne une série de composés agissant en tant qu'inhibiteurs de CDK4/6. L'invention concerne particulièrement, des composés représentés par la formule (I), des sels pharmaceutiquement acceptables ou des isomères de ceux-ci, des compositions pharmaceutiques les contenant, et leur utilisation dans la préparation de médicaments pour le traitement de cancers.
CA3046864A 2016-12-16 2017-12-15 Inhibiteur de cdk4/6 Active CA3046864C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN201611170508.1 2016-12-16
CN201611170508 2016-12-16
CN201710787583 2017-09-04
CN201710787583.0 2017-09-04
PCT/CN2017/116611 WO2018108167A1 (fr) 2016-12-16 2017-12-15 Inhibiteur de cdk4/6

Publications (2)

Publication Number Publication Date
CA3046864A1 CA3046864A1 (fr) 2018-06-21
CA3046864C true CA3046864C (fr) 2025-09-16

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