CA3055156C - Molecules de fusion d'ectodomaines du recepteur du tgf-.beta. et leurs utilisations - Google Patents

Molecules de fusion d'ectodomaines du recepteur du tgf-.beta. et leurs utilisations

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Publication number
CA3055156C
CA3055156C CA3055156A CA3055156A CA3055156C CA 3055156 C CA3055156 C CA 3055156C CA 3055156 A CA3055156 A CA 3055156A CA 3055156 A CA3055156 A CA 3055156A CA 3055156 C CA3055156 C CA 3055156C
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Canada
Prior art keywords
seq
polypeptide construct
amino acid
tgf
polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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CA3055156A
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English (en)
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CA3055156A1 (fr
Inventor
Traian Sulea
Maureen D. O'Connor-McCourt
John C. Zwaagstra
Anne E.G. Lenferink
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National Research Council of Canada
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Priority claimed from PCT/IB2018/051320 external-priority patent/WO2018158727A1/fr
Publication of CA3055156A1 publication Critical patent/CA3055156A1/fr
Application granted granted Critical
Publication of CA3055156C publication Critical patent/CA3055156C/fr
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Abstract

La présente invention concerne, en général, des polypeptides capables de se lier à des ligands du facteur de croissance transformant bêta (TGF-β) et de les neutraliser, et des utilisations de ces polypeptides pour traiter des troubles liés à l'activation ou à l'expression de TGF-bêta (par exemple, le cancer et des maladies fibreuses), et des méthodes de production de telles molécules.
CA3055156A 2017-03-02 2018-03-01 Molecules de fusion d'ectodomaines du recepteur du tgf-.beta. et leurs utilisations Active CA3055156C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762465969P 2017-03-02 2017-03-02
US62/465,969 2017-03-02
US201762468586P 2017-03-08 2017-03-08
US62/468,586 2017-03-08
PCT/IB2018/051320 WO2018158727A1 (fr) 2017-03-02 2018-03-01 Molécules de fusion d'ectodomaines du récepteur du tgf-b et leurs utilisations

Publications (2)

Publication Number Publication Date
CA3055156A1 CA3055156A1 (fr) 2018-09-07
CA3055156C true CA3055156C (fr) 2026-02-24

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