CA3062452C - Compositions, combinaisons et methodes connexes pour le traitement de troubles neurologiques - Google Patents

Compositions, combinaisons et methodes connexes pour le traitement de troubles neurologiques Download PDF

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Publication number
CA3062452C
CA3062452C CA3062452A CA3062452A CA3062452C CA 3062452 C CA3062452 C CA 3062452C CA 3062452 A CA3062452 A CA 3062452A CA 3062452 A CA3062452 A CA 3062452A CA 3062452 C CA3062452 C CA 3062452C
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CA
Canada
Prior art keywords
compound
hydrogen
phenoxy
propan
deramciclane
Prior art date
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Active
Application number
CA3062452A
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English (en)
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CA3062452A1 (fr
Inventor
Sreenivasarao Vepachedu
Hans J. MOEBIUS
Anton Bespalov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Exciva GmbH
Original Assignee
Exciva GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2017/048748 external-priority patent/WO2018039642A1/fr
Application filed by Exciva GmbH filed Critical Exciva GmbH
Priority to CA3138116A priority Critical patent/CA3138116A1/fr
Publication of CA3062452A1 publication Critical patent/CA3062452A1/fr
Application granted granted Critical
Publication of CA3062452C publication Critical patent/CA3062452C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225—Polycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne des composés de la formule I, des sels pharmaceutiquement acceptables de ces derniers, leurs énantiomères, leurs métabolites, leurs dérivés, leurs promédicaments, leurs sels pharmaceutiquement acceptables, leurs N-oxydes, ou une association de ces derniers, des procédés et des intermédiaires pour leur préparation, des compositions les contenant, et leurs utilisations. L'invention concerne des compositions pharmaceutiques comprenant un composé de la formule I, ou ses énantiomères, ses métabolites, ses dérivés, ses promédicaments, ses sels d'addition d'acide, ses sels pharmaceutiquement acceptables, ou ses N-oxydes, ou une association de ces derniers, le composé étant un agent ou un ligand double et/ou un triple pour les récepteurs CYP2D6, 5-HT2A et/ou 5 HT2C, et/ou l'acétylcholinestérase.
CA3062452A 2017-05-04 2018-05-03 Compositions, combinaisons et methodes connexes pour le traitement de troubles neurologiques Active CA3062452C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3138116A CA3138116A1 (fr) 2017-05-04 2018-05-03 Nouvelles compositions, combinaisons et methodes connexes

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US201762501696P 2017-05-04 2017-05-04
US62/501,696 2017-05-04
USPCT/US2017/048748 2017-08-25
PCT/US2017/048748 WO2018039642A1 (fr) 2016-08-26 2017-08-25 Compositions et procédés associés
TW106129169 2017-08-28
TW106129169A TW201815387A (zh) 2016-08-26 2017-08-28 組成物及其方法
US201862634162P 2018-02-22 2018-02-22
US62/634,162 2018-02-22
US201862635554P 2018-02-27 2018-02-27
US201862636099P 2018-02-27 2018-02-27
US62/635,554 2018-02-27
US62/636,099 2018-02-27
US201862636171P 2018-02-28 2018-02-28
US62/636,171 2018-02-28
PCT/US2018/030978 WO2018204713A1 (fr) 2017-05-04 2018-05-03 Targeted drug rescue avec de nouvelles compositions, associations et procédés correspondants

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3138116A Division CA3138116A1 (fr) 2017-05-04 2018-05-03 Nouvelles compositions, combinaisons et methodes connexes

Publications (2)

Publication Number Publication Date
CA3062452A1 CA3062452A1 (fr) 2018-11-08
CA3062452C true CA3062452C (fr) 2023-10-24

Family

ID=65431106

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3062452A Active CA3062452C (fr) 2017-05-04 2018-05-03 Compositions, combinaisons et methodes connexes pour le traitement de troubles neurologiques
CA3138116A Pending CA3138116A1 (fr) 2017-05-04 2018-05-03 Nouvelles compositions, combinaisons et methodes connexes

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA3138116A Pending CA3138116A1 (fr) 2017-05-04 2018-05-03 Nouvelles compositions, combinaisons et methodes connexes

Country Status (13)

Country Link
EP (1) EP3618819A4 (fr)
JP (2) JP7514078B2 (fr)
KR (2) KR20200062078A (fr)
CN (1) CN110831584B (fr)
AU (2) AU2018261654A1 (fr)
BR (1) BR112019022902A2 (fr)
CA (2) CA3062452C (fr)
IL (1) IL270326B2 (fr)
MA (1) MA49464A (fr)
RU (1) RU2760558C9 (fr)
TW (1) TWI787260B (fr)
WO (1) WO2018204713A1 (fr)
ZA (1) ZA201908006B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA49464A (fr) * 2017-05-04 2020-04-29 Exciva GmbH Targeted drug rescue avec de nouvelles compositions, associations et procédés correspondants
EP3941469A4 (fr) * 2019-03-18 2022-05-18 Avanir Pharmaceuticals, Inc. Méthodes de traitement de symptômes négatifs de la schizophrénie à l'aide de dextrométhorphane deutéré et de quinidine
KR102820594B1 (ko) * 2019-06-06 2025-06-16 제이에스알 가부시키가이샤 감방사선성 수지 조성물, 레지스트 패턴 형성 방법 및 화합물
US12240813B2 (en) 2020-05-19 2025-03-04 Cybin Irl Limited Deuterated tryptamine derivatives and methods of use
CN116473077B (zh) * 2023-05-08 2025-04-11 广东方中高新材料有限公司 一种n,n配位的镓配合物抗菌剂的合成和应用
CN116473073A (zh) * 2023-05-08 2023-07-25 广东方中高新材料有限公司 一种含镓配合物的吡唑醚菌酯增效悬浮制剂及其制备方法
CN119432479B (zh) * 2023-08-04 2025-10-03 中国石油天然气股份有限公司 柴油机润滑油组合物及其制备方法
CN120987847B (zh) * 2024-11-29 2026-02-17 江苏恩华药业股份有限公司 一种氢溴酸右美沙芬的制备方法

Family Cites Families (17)

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US4241065A (en) * 1979-07-02 1980-12-23 E. I. Du Pont De Nemours And Company Fluoro analogs of hydrocodone and oxycodone useful as analgesics, narcotic antagonists or both
US4950658A (en) * 1988-12-06 1990-08-21 Board Of Trustees Of Southern Illinois Univ. Method of medical treatment of Alzheimer's disease
US5891885A (en) 1996-10-09 1999-04-06 Algos Pharmaceutical Corporation Method for treating migraine
US6207674B1 (en) 1999-12-22 2001-03-27 Richard A. Smith Dextromethorphan and oxidase inhibitor for weaning patients from narcotics and anti-depressants
US6335371B1 (en) * 2000-11-28 2002-01-01 Orion Corporation Method for inducing cognition enhancement
TWI326214B (en) 2002-07-17 2010-06-21 Avanir Pharmaceuticals Inc Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders
US20070099947A1 (en) * 2005-11-03 2007-05-03 Alkermes, Inc. Methods and compositions for the treatment of brain reward system disorders by combination therapy
JP2009525343A (ja) 2006-02-03 2009-07-09 アバニール・ファーマシューティカルズ 鬱病、不安および神経変性疾患を治療するためのデキストロメトルファンおよびキニジンを含む薬剤組成物
AU2008247818B2 (en) * 2007-05-01 2011-10-20 Sun Pharmaceutical Industries, Inc. Morphinan compounds
JP5466147B2 (ja) * 2007-05-21 2014-04-09 レビバ ファーマシューティカルズ，インコーポレーテッド キノリノン系非定型抗精神病薬剤の組成物、合成、及び使用方法
US8017623B2 (en) * 2008-07-03 2011-09-13 Trinity Laboratories, Inc. Dextromethorphan hydrochloride
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EP4166141A1 (fr) * 2014-09-14 2023-04-19 Avanir Pharmaceuticals, Inc. Combinaisons du dextrométhorphane deuterée et de la quinidine destinées au traitement de l'agitation et de l'aggresitivé chez la démence d'alzheimer
JP7096813B2 (ja) * 2016-08-26 2022-07-06 エクシーバ ゲーエムベーハー 組成物及びその方法
MA49464A (fr) * 2017-05-04 2020-04-29 Exciva GmbH Targeted drug rescue avec de nouvelles compositions, associations et procédés correspondants

Also Published As

Publication number Publication date
RU2019137004A (ru) 2021-06-04
RU2019137004A3 (fr) 2021-06-04
EP3618819A1 (fr) 2020-03-11
JP2023143940A (ja) 2023-10-06
RU2760558C2 (ru) 2021-11-29
AU2021215274B2 (en) 2022-11-03
CA3138116A1 (fr) 2018-11-08
KR102444803B1 (ko) 2022-09-19
IL270326A (fr) 2018-05-03
CN110831584A (zh) 2020-02-21
KR20200062078A (ko) 2020-06-03
AU2021215274A1 (en) 2021-09-02
JP7514078B2 (ja) 2024-07-10
JP2020518617A (ja) 2020-06-25
AU2018261654A1 (en) 2019-11-14
CN110831584B (zh) 2023-03-10
RU2760558C9 (ru) 2022-02-22
IL270326B (en) 2022-10-01
WO2018204713A1 (fr) 2018-11-08
IL270326B2 (en) 2023-02-01
CA3062452A1 (fr) 2018-11-08
KR20210130827A (ko) 2021-11-01
TW201842902A (zh) 2018-12-16
TWI787260B (zh) 2022-12-21
MA49464A (fr) 2020-04-29
EP3618819A4 (fr) 2021-01-20
BR112019022902A2 (pt) 2020-05-19
ZA201908006B (en) 2021-04-28

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