CA3068122C - Analyse parallele multiplexee enrichie en cible pour l'evaluation de biomarqueurs tumoraux - Google Patents

Analyse parallele multiplexee enrichie en cible pour l'evaluation de biomarqueurs tumoraux

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Publication number
CA3068122C
CA3068122C CA3068122A CA3068122A CA3068122C CA 3068122 C CA3068122 C CA 3068122C CA 3068122 A CA3068122 A CA 3068122A CA 3068122 A CA3068122 A CA 3068122A CA 3068122 C CA3068122 C CA 3068122C
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sequences
interest
pool
sequence
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CA3068122A
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CA3068122A1 (fr
Inventor
George KOUMBARIS
Marios Ioannides
Elena KYPRI
Acilleas Achilleos
Petros MINA
Alexia Eliades
Charalambos Loizides
Philippos Patsalis
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Medicover Public Co Ltd
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Priority claimed from PCT/EP2018/068441 external-priority patent/WO2019008172A1/fr
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Abstract

L'invention concerne des méthodes d'évaluation de biomarqueurs tumoraux dans des échantillons biologiques à l'aide d'une analyse parallèle multiplexée enrichie en cible. Les méthodes de l'invention utilisent des Séquences de Capture Cibles (TACS) pour enrichir ainsi des séquences cibles d'intérêt, suivi par un séquençage parallèle massif et une analyse statistique de la population enrichie. Les méthodes peuvent être utilisées avec des échantillons d'ADN provenant d'un patient, tel qu'une biopsie de tissu ou un échantillon de plasma (biopsie liquide), pour la détection de la présence de biomarqueurs tumoraux, par exemple, à des fins de diagnostic, de criblage, de sélection de thérapie et/ou de surveillance de traitement. Des kits pour mettre en uvre les méthodes de l'invention sont également décrits.
CA3068122A 2017-07-07 2018-07-06 Analyse parallele multiplexee enrichie en cible pour l'evaluation de biomarqueurs tumoraux Active CA3068122C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762529779P 2017-07-07 2017-07-07
US62/529,779 2017-07-07
PCT/EP2018/068441 WO2019008172A1 (fr) 2017-07-07 2018-07-06 Analyse parallèle multiplexée enrichie en cible pour l'évaluation de biomarqueurs tumoraux

Publications (2)

Publication Number Publication Date
CA3068122A1 CA3068122A1 (fr) 2019-01-10
CA3068122C true CA3068122C (fr) 2026-05-05

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