CA3071685C - Systemes, dispositifs et procedes de traitement d'image pour generer une image presentant un marquage predictif - Google Patents

Systemes, dispositifs et procedes de traitement d'image pour generer une image presentant un marquage predictif Download PDF

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CA3071685C
CA3071685C CA3071685A CA3071685A CA3071685C CA 3071685 C CA3071685 C CA 3071685C CA 3071685 A CA3071685 A CA 3071685A CA 3071685 A CA3071685 A CA 3071685A CA 3071685 C CA3071685 C CA 3071685C
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image
images
microscopy
microscopy images
fluorescence
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CA3071685A1 (fr
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Gregory Johnson
Chawin OUNKOMOL
Forrest COLLMAN
Sharmishtaa Seshamani
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Allen Institute
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Allen Institute
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    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/10—Segmentation; Edge detection
    • G06T7/11—Region-based segmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/026—Measuring blood flow
    • A61B5/0275—Measuring blood flow using tracers, e.g. dye dilution
    • G—PHYSICS
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    • G02B21/008—Details of detection or image processing, including general computer control
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    • G06V20/698—Matching; Classification
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    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1488—Methods for deciding
    • G—PHYSICS
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    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10016—Video; Image sequence
    • G—PHYSICS
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    • G06T2207/00—Indexing scheme for image analysis or image enhancement
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    • G06T2207/10056—Microscopic image
    • G—PHYSICS
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    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10056—Microscopic image
    • G06T2207/10061—Microscopic image from scanning electron microscope
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
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    • G06T2207/10—Image acquisition modality
    • G06T2207/10064—Fluorescence image
    • G—PHYSICS
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    • G06T2207/00—Indexing scheme for image analysis or image enhancement
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    • G06T2207/20081—Training; Learning
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    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/20—Special algorithmic details
    • G06T2207/20084—Artificial neural networks [ANN]
    • G—PHYSICS
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    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30024—Cell structures in vitro; Tissue sections in vitro

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  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Multimedia (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Software Systems (AREA)
  • Evolutionary Computation (AREA)
  • Artificial Intelligence (AREA)
  • General Engineering & Computer Science (AREA)
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  • Data Mining & Analysis (AREA)
  • Chemical & Material Sciences (AREA)
  • Mathematical Physics (AREA)
  • Biophysics (AREA)
  • Computational Linguistics (AREA)
  • Medical Informatics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Databases & Information Systems (AREA)
  • Signal Processing (AREA)
  • Optics & Photonics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physiology (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)

Abstract

La présente invention concerne un dispositif informatique, un procédé, un système et des instructions dans un support lisible par ordinateur non transitoire pour effectuer une analyse d'image sur des images de microscopie 3D afin de prédire la localisation et/ou le marquage de diverses structures ou de divers objets d'intérêt, par prédiction de l'emplacement dans de telles images où un colorant ou un autre marqueur associé à ces structures apparaît. Le dispositif informatique, le procédé et le système reçoivent des ensembles d'images 3D qui comprennent des images non marquées, telles que des images de lumière transmise ou des images de microscope électronique, et des images marquées, telles que des images capturées avec un marquage par fluorescence. Le dispositif informatique entraîne un modèle statistique pour associer des structures dans les images marquées aux mêmes structures dans les images de lumière non marquées. Le processeur applique en outre le modèle statistique à une nouvelle image non marquée pour générer une image marquée prédictive qui prédit l'emplacement d'une structure d'intérêt dans la nouvelle image.
CA3071685A 2017-08-09 2018-08-08 Systemes, dispositifs et procedes de traitement d'image pour generer une image presentant un marquage predictif Active CA3071685C (fr)

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Application Number Priority Date Filing Date Title
CA3213179A CA3213179A1 (fr) 2017-08-09 2018-08-08 Systemes, dispositifs et procedes de traitement d'image pour generer une image presentant un marquage predictif

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201762543333P 2017-08-09 2017-08-09
US62/543,333 2017-08-09
US201762560043P 2017-09-18 2017-09-18
US62/560,043 2017-09-18
US201762568749P 2017-10-05 2017-10-05
US62/568,749 2017-10-05
US201862647456P 2018-03-23 2018-03-23
US62/647,456 2018-03-23
US201862651765P 2018-04-03 2018-04-03
US62/651,765 2018-04-03
PCT/US2018/045840 WO2019032723A1 (fr) 2017-08-09 2018-08-08 Systèmes, dispositifs et procédés de traitement d'image pour générer une image présentant un marquage prédictif

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CA3071685C true CA3071685C (fr) 2023-11-21

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CA3213179A Pending CA3213179A1 (fr) 2017-08-09 2018-08-08 Systemes, dispositifs et procedes de traitement d'image pour generer une image presentant un marquage predictif

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US (3) US10935773B2 (fr)
EP (1) EP3664705A4 (fr)
JP (2) JP2020530637A (fr)
AU (1) AU2018313841B2 (fr)
CA (2) CA3071685C (fr)
WO (1) WO2019032723A1 (fr)

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