CA3072384C - Molecules anti-cd137 et utilisation correspondante - Google Patents

Molecules anti-cd137 et utilisation correspondante

Info

Publication number
CA3072384C
CA3072384C CA3072384A CA3072384A CA3072384C CA 3072384 C CA3072384 C CA 3072384C CA 3072384 A CA3072384 A CA 3072384A CA 3072384 A CA3072384 A CA 3072384A CA 3072384 C CA3072384 C CA 3072384C
Authority
CA
Canada
Prior art keywords
antibody
antigen
human
amino acid
binding fragment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3072384A
Other languages
English (en)
Other versions
CA3072384A1 (fr
Inventor
Peter Peizhi Luo
Fangyong Du
Guizhong Liu
Yan Li
Jun Chen
Xiaohong She
Peter Cheung
Original Assignee
Adagene Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/CN2017/098332 external-priority patent/WO2019036855A1/fr
Application filed by Adagene Inc filed Critical Adagene Inc
Publication of CA3072384A1 publication Critical patent/CA3072384A1/fr
Application granted granted Critical
Publication of CA3072384C publication Critical patent/CA3072384C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Abstract

L'invention concerne des anticorps se liant au CD137 humain ou des fragments de liaison à l'antigène de ceux-ci, un acide nucléique codant pour ceux-ci, des compositions thérapeutiques correspondantes, ainsi que leur utilisation pour améliorer la fonction de lymphocytes T afin de réguler à la hausse les réponses immunitaires à médiation cellulaire et pour le traitement de troubles dysfonctionnels des lymphocytes T, par exemple une immunité tumorale, et pour le traitement de cancer.
CA3072384A 2017-08-21 2018-08-21 Molecules anti-cd137 et utilisation correspondante Active CA3072384C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/CN2017/098332 WO2019036855A1 (fr) 2017-08-21 2017-08-21 Molécules anti-cd137 et leur utilisation
CNPCT/CN2017/098332 2017-08-21
PCT/CN2018/101501 WO2019037711A1 (fr) 2017-08-21 2018-08-21 Molécules anti-cd137 et utilisation correspondante

Publications (2)

Publication Number Publication Date
CA3072384A1 CA3072384A1 (fr) 2019-02-28
CA3072384C true CA3072384C (fr) 2025-09-23

Family

ID=

Similar Documents

Publication Publication Date Title
US12378319B2 (en) Anti-CD137 molecules and use thereof
US10640568B2 (en) 4-1BB binding molecules
WO2019105468A1 (fr) Méthodes d'utilisation du ligand cd137 comme biomarqueur pour le traitement avec un anticorps anti-cd137
US20220089757A1 (en) Anti-cd137l antibodies and methods of using same
CA3072384C (fr) Molecules anti-cd137 et utilisation correspondante
AU2013201617B2 (en) 4-1BB binding molecules