CA3081956A1 - Oligonucleotides conjugues a une fraction ligand du recepteur de glp-1 et leurs utilisations - Google Patents

Oligonucleotides conjugues a une fraction ligand du recepteur de glp-1 et leurs utilisations Download PDF

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Publication number
CA3081956A1
CA3081956A1 CA3081956A CA3081956A CA3081956A1 CA 3081956 A1 CA3081956 A1 CA 3081956A1 CA 3081956 A CA3081956 A CA 3081956A CA 3081956 A CA3081956 A CA 3081956A CA 3081956 A1 CA3081956 A1 CA 3081956A1
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CA
Canada
Prior art keywords
glp
compound
oligonucleotide
certain embodiments
ser
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3081956A
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English (en)
Inventor
Brett P. Monia
Thazha P. Prakash
Garth A. Kinberger
Richard Lee
Punit P. Seth
Michael OESTERGAARD
Mehran Nikan
Shalini Andersson
Eva Carina Ammala
Daniel Laurent Knerr
Maria Olwegard-Halvarsson
William John Drury Iii
Eric Valeur
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Ionis Pharmaceuticals Inc
Original Assignee
AstraZeneca AB
Ionis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB, Ionis Pharmaceuticals Inc filed Critical AstraZeneca AB
Publication of CA3081956A1 publication Critical patent/CA3081956A1/fr
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6425—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a receptor, e.g. CD4, a cell surface antigen, i.e. not a peptide ligand targeting the antigen, or a cell surface determinant, i.e. a part of the surface of a cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/315—Phosphorothioates
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
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    • C12N2310/3341—5-Methylcytosine
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  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)

Abstract

Les modes de réalisation de la présente invention concernent des composés et des procédés de ciblage de cellules exprimant le récepteur GLP-1.
CA3081956A 2017-11-08 2018-11-07 Oligonucleotides conjugues a une fraction ligand du recepteur de glp-1 et leurs utilisations Pending CA3081956A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762583398P 2017-11-08 2017-11-08
US62/583,398 2017-11-08
US201862725176P 2018-08-30 2018-08-30
US62/725,176 2018-08-30
PCT/IB2018/058752 WO2019092618A2 (fr) 2017-11-08 2018-11-07 Oligonucléotides conjugués à une fraction ligand du récepteur de glp-1 et leurs utilisations

Publications (1)

Publication Number Publication Date
CA3081956A1 true CA3081956A1 (fr) 2019-05-16

Family

ID=66437703

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3081956A Pending CA3081956A1 (fr) 2017-11-08 2018-11-07 Oligonucleotides conjugues a une fraction ligand du recepteur de glp-1 et leurs utilisations

Country Status (10)

Country Link
US (2) US20200268898A1 (fr)
EP (1) EP3707156A4 (fr)
JP (2) JP7503492B2 (fr)
KR (2) KR102933083B1 (fr)
CN (2) CN119876131A (fr)
AU (4) AU2018364621A1 (fr)
BR (1) BR112020008937A2 (fr)
CA (1) CA3081956A1 (fr)
IL (2) IL274508B1 (fr)
WO (1) WO2019092618A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104968783B (zh) * 2012-10-15 2019-12-10 Ionis制药公司 用于调节c9orf72表达的组合物
WO2021092347A1 (fr) * 2019-11-08 2021-05-14 Sanford Burnham Prebys Medical Discovery Institute Méthodes et compositions pour la thérapie du diabète sucré de type 2
AU2021285138A1 (en) * 2020-06-03 2023-02-02 Københavns Universitet GLP1R agonist NMDAR antagonist conjugates
CN112121152B (zh) * 2020-09-25 2021-06-22 南京大学 利司那肽在制备抗肿瘤药物中的应用
CN113249288B9 (zh) * 2021-07-13 2021-11-09 奥锐特药业(天津)有限公司 一种表达glp-1类似物的重组菌及其应用
CN118344462B (zh) * 2024-06-18 2024-11-08 苏州易合医药有限公司 一种用于肺部给药的索马鲁肽突变体、融合蛋白及相关产品

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100280098A1 (en) * 2007-10-05 2010-11-04 Juliano Rudolph L Receptor targeted oligonucleotides
WO2009089186A2 (fr) * 2008-01-05 2009-07-16 Sloan-Kettering Institute For Cancer Research Oligonucléotide thérapeutique conjugué à un peptide et procédé de fabrication et d'utilisation de l'oligonucléotide
MX2012013001A (es) * 2010-05-13 2013-02-26 Univ Indiana Res & Tech Corp Peptidos de la superfamilia de glucagon que presentan actividad del receptor nuclear de hormonas.
RS56173B1 (sr) 2011-06-22 2017-11-30 Univ Indiana Res & Tech Corp Koagonisti receptora za glukagon/glp-1 receptora
KR20140043793A (ko) 2011-06-22 2014-04-10 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 글루카곤/glp-1 수용체 공동-작용물질
AU2014282666A1 (en) 2013-06-16 2016-01-07 National University Corporation Tokyo Medical And Dental University Double-stranded antisense nucleic acid with exon-skipping effect
EP3065783A4 (fr) * 2013-11-06 2017-06-21 Merck Sharp & Dohme Corp. Double distribution moléculaire de conjugués contenant des oligonucléotides et des peptides
US10407683B2 (en) * 2014-07-16 2019-09-10 Modernatx, Inc. Circular polynucleotides
CA2955375A1 (fr) * 2014-07-17 2016-01-21 Modernatx, Inc. Modifications de terminal de polynucleotides
WO2017192820A1 (fr) * 2016-05-06 2017-11-09 Ionis Pharmaceuticals, Inc. Oligonucléotides conjugués à une fraction ligand du récepteur de glp-1 et leurs utilisations

Also Published As

Publication number Publication date
WO2019092618A2 (fr) 2019-05-16
KR20200090778A (ko) 2020-07-29
AU2025204342A1 (en) 2025-07-03
IL274508B1 (en) 2026-01-01
KR20260033117A (ko) 2026-03-10
US20240293563A1 (en) 2024-09-05
WO2019092618A3 (fr) 2019-07-18
EP3707156A4 (fr) 2021-08-04
US20200268898A1 (en) 2020-08-27
AU2018364621A1 (en) 2020-06-18
CN111448207B (zh) 2024-11-01
CN111448207A (zh) 2020-07-24
JP7503492B2 (ja) 2024-06-20
JP7815175B2 (ja) 2026-02-17
IL325485A (en) 2026-02-01
JP2023123493A (ja) 2023-09-05
WO2019092618A9 (fr) 2020-06-18
JP2021502359A (ja) 2021-01-28
EP3707156A2 (fr) 2020-09-16
IL274508A (en) 2020-06-30
KR102933083B1 (ko) 2026-03-09
CN119876131A (zh) 2025-04-25
AU2021240124A1 (en) 2021-10-28
AU2023203779A1 (en) 2023-08-17
AU2018364621A2 (en) 2020-06-25
BR112020008937A2 (pt) 2020-10-20

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