CA3089231C - Variants secreteurs de mda-7/il-24 et methodes d'utilisation - Google Patents

Variants secreteurs de mda-7/il-24 et methodes d'utilisation

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Publication number
CA3089231C
CA3089231C CA3089231A CA3089231A CA3089231C CA 3089231 C CA3089231 C CA 3089231C CA 3089231 A CA3089231 A CA 3089231A CA 3089231 A CA3089231 A CA 3089231A CA 3089231 C CA3089231 C CA 3089231C
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CA
Canada
Prior art keywords
mda
protein
seq
polynucleotide
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3089231A
Other languages
English (en)
Other versions
CA3089231A1 (fr
Inventor
Luni Emdad
Swadesh K. Das
Paul B. Fisher
Mitchell E. MENEZES
Praveen Bhoopathi
Devanand Sarkar
Anjan K. PRADHAN
Xiang-Yang Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Virginia Commonwealth University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Virginia Commonwealth University filed Critical Virginia Commonwealth University
Priority claimed from PCT/US2019/014686 external-priority patent/WO2019147623A2/fr
Publication of CA3089231A1 publication Critical patent/CA3089231A1/fr
Application granted granted Critical
Publication of CA3089231C publication Critical patent/CA3089231C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Abstract

Dans divers aspects, la présente invention concerne des polynucléotides codant pour une protéine de fusion, ainsi que des vecteurs, des cellules et des compositions les comprenant. Dans des modes de réalisation, la protéine de fusion comprend un peptide signal d'insuline et une protéine MDA-7/IL-24. L'invention concerne également des procédés d'utilisation des polynucléotides, vecteurs, cellules et compositions, comme dans le traitement ou la prévention du cancer.
CA3089231A 2018-01-23 2019-01-23 Variants secreteurs de mda-7/il-24 et methodes d'utilisation Active CA3089231C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862620649P 2018-01-23 2018-01-23
US201862620673P 2018-01-23 2018-01-23
US62/620,649 2018-01-23
US62/620,673 2018-01-23
PCT/US2019/014686 WO2019147623A2 (fr) 2018-01-23 2019-01-23 Variants sécrétoires de mda-7/il et procédés d'utilisation

Publications (2)

Publication Number Publication Date
CA3089231A1 CA3089231A1 (fr) 2019-08-01
CA3089231C true CA3089231C (fr) 2026-01-06

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