CA3093585A1 - Formation de reseaux de cryptes intestinales planaires possedant un compartiment de cellules souches/proliferatives et une zone cellulaire differenciee - Google Patents

Formation de reseaux de cryptes intestinales planaires possedant un compartiment de cellules souches/proliferatives et une zone cellulaire differenciee Download PDF

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Publication number
CA3093585A1
CA3093585A1 CA3093585A CA3093585A CA3093585A1 CA 3093585 A1 CA3093585 A1 CA 3093585A1 CA 3093585 A CA3093585 A CA 3093585A CA 3093585 A CA3093585 A CA 3093585A CA 3093585 A1 CA3093585 A1 CA 3093585A1
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cell
cells
support substrate
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CA3093585A
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English (en)
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Nancy L. Allbritton
Yuli Wang
Raehyun KIM
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University of North Carolina at Chapel Hill
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University of North Carolina at Chapel Hill
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Publication of CA3093585A1 publication Critical patent/CA3093585A1/fr
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3813—Epithelial cells, e.g. keratinocytes, urothelial cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/02—Membranes; Filters
    • C12M25/04—Membranes; Filters in combination with well or multiwell plates, i.e. culture inserts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/04—Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/08—Chemical, biochemical or biological means, e.g. plasma jet, co-culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • C12Q1/06—Quantitative determination
    • C12Q1/08—Quantitative determination using multifield media

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physiology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Botany (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Mechanical Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

L'invention concerne un procédé de production de constructions tissulaires comprenant deux régions distinctes ou plus, chacune comprenant une population ou une lignée cellulaire différente. Le procédé consiste à utiliser un substrat support ou un ensemble substrat comprenant deux régions physiquement distinctes ou plus, les deux régions physiquement distinctes ou plus du substrat support ou de l'ensemble substrat étant différentes l'une de l'autre ; et à déposer/positionner une ou plusieurs cellules sur le substrat support ou l'ensemble substrat. Les cellules peuvent former une monocouche continue pourvue d'au moins deux zones, par exemple une zone proliférative et une zone non proliférative, qui peuvent agir en tant que modèles intestinaux in vitro. Les modèles sont bidimensionnels, facilitant ainsi une imagerie rapide et facile. L'invention porte également sur des systèmes comprenant les constructions tissulaires et sur des procédés d'utilisation des constructions pour étudier les effets de produits pharmaceutiques, de produits nutraceutiques et de métabolites sur des cellules intestinales.
CA3093585A 2018-05-25 2019-05-24 Formation de reseaux de cryptes intestinales planaires possedant un compartiment de cellules souches/proliferatives et une zone cellulaire differenciee Pending CA3093585A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862676418P 2018-05-25 2018-05-25
US62/676,418 2018-05-25
PCT/US2019/033955 WO2019227012A1 (fr) 2018-05-25 2019-05-24 Formation de réseaux de cryptes intestinales planaires possédant un compartiment de cellules souches/prolifératives et une zone cellulaire différenciée

Publications (1)

Publication Number Publication Date
CA3093585A1 true CA3093585A1 (fr) 2019-11-28

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ID=68617281

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3093585A Pending CA3093585A1 (fr) 2018-05-25 2019-05-24 Formation de reseaux de cryptes intestinales planaires possedant un compartiment de cellules souches/proliferatives et une zone cellulaire differenciee

Country Status (5)

Country Link
US (2) US20230098968A1 (fr)
EP (1) EP3802848A4 (fr)
JP (2) JP7451427B2 (fr)
CA (1) CA3093585A1 (fr)
WO (1) WO2019227012A1 (fr)

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CA3009153A1 (fr) 2015-01-30 2016-08-04 The University Of North Carolina At Chapel Hill Procedes pour generer des constructions de tissu epithelial gastro-intestinal
JP7371012B2 (ja) 2018-05-15 2023-10-30 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル インビトロ細胞培養の為の自己持続型の低酸素状態並びにガス勾配及び非ガス化学勾配を生成するデバイス、システム、及び装置
JP7451427B2 (ja) 2018-05-25 2024-03-18 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 幹細胞／増殖細胞区画及び分化細胞ゾーンを有する平面腸陰窩のアレイの形成
US12410391B2 (en) 2018-11-16 2025-09-09 The University Of North Carolina At Chapel Hill In vitro cell culture mucus systems
CA3170294A1 (fr) * 2020-04-03 2021-10-07 Nancy L. Allbritton Procedes pour enrichir des cellules enteroendocrines et leurs sous-types dans des systemes monocouches intestinaux contigus
WO2023104915A1 (fr) * 2021-12-08 2023-06-15 Inserm (Institut National De La Sante Et De La Recherche Medicale) Système microphysiologique et ses utilisations
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JP7451427B2 (ja) 2018-05-25 2024-03-18 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 幹細胞／増殖細胞区画及び分化細胞ゾーンを有する平面腸陰窩のアレイの形成
US12410391B2 (en) 2018-11-16 2025-09-09 The University Of North Carolina At Chapel Hill In vitro cell culture mucus systems

Also Published As

Publication number Publication date
EP3802848A1 (fr) 2021-04-14
WO2019227012A1 (fr) 2019-11-28
EP3802848A4 (fr) 2022-03-09
US12195706B2 (en) 2025-01-14
JP7799729B2 (ja) 2026-01-15
JP2021525075A (ja) 2021-09-24
US20230098968A1 (en) 2023-03-30
US20240010960A1 (en) 2024-01-11
JP2024063198A (ja) 2024-05-10
JP7451427B2 (ja) 2024-03-18

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