CA3102600C - Systeme centrifuge pour separer des cellules en suspension - Google Patents

Systeme centrifuge pour separer des cellules en suspension Download PDF

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Publication number
CA3102600C
CA3102600C CA3102600A CA3102600A CA3102600C CA 3102600 C CA3102600 C CA 3102600C CA 3102600 A CA3102600 A CA 3102600A CA 3102600 A CA3102600 A CA 3102600A CA 3102600 C CA3102600 C CA 3102600C
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CA
Canada
Prior art keywords
centrate
concentrate
pump
opening
chamber
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3102600A
Other languages
English (en)
Other versions
CA3102600A1 (fr
Inventor
S Kessler
T Marro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pneumatic Scale Corp
Original Assignee
Pneumatic Scale Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pneumatic Scale Corp filed Critical Pneumatic Scale Corp
Publication of CA3102600A1 publication Critical patent/CA3102600A1/fr
Application granted granted Critical
Publication of CA3102600C publication Critical patent/CA3102600C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B11/00—Feeding, charging, or discharging bowls
    • B04B11/04—Periodical feeding or discharging; Control arrangements therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D21/00—Separation of suspended solid particles from liquids by sedimentation
    • B01D21/26—Separation of sediment aided by centrifugal force or centripetal force
    • B01D21/262—Separation of sediment aided by centrifugal force or centripetal force by using a centrifuge
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D21/00—Separation of suspended solid particles from liquids by sedimentation
    • B01D21/30—Control equipment
    • B01D21/32—Density control of clear liquid or sediment, e.g. optical control ; Control of physical properties
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B11/00—Feeding, charging, or discharging bowls
    • B04B11/02—Continuous feeding or discharging; Control arrangements therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B11/00—Feeding, charging, or discharging bowls
    • B04B11/08—Skimmers or scrapers for discharging ; Regulating thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B11/00—Feeding, charging, or discharging bowls
    • B04B11/08—Skimmers or scrapers for discharging ; Regulating thereof
    • B04B11/082—Skimmers for discharging liquid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B13/00—Control arrangements specially designed for centrifuges; Program control of centrifuges
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B7/00—Elements of centrifuges
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B7/00—Elements of centrifuges
    • B04B7/08—Rotary bowls
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/02—Separating microorganisms from the culture medium; Concentration of biomass
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2221/00—Applications of separation devices
    • B01D2221/10—Separation devices for use in medical, pharmaceutical or laboratory applications, e.g. separating amalgam from dental treatment residues
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B04B2005/0464—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation with hollow or massive core in centrifuge bowl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Centrifugal Separators (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

La présente invention concerne un appareil pour séparer un matériau de suspension cellulaire en centrat et concentré, qui comprend une structure à usage unique (178, 240, 250) positionnée amovible dans une cavité dans un bol centrifuge rotatif à paroi solide (172). Le bol et les parties de la structure à usage unique tournent autour d'un axe (174). Un tube d'alimentation d'entrée fixe (184), un tube d'évacuation de centrat (212) et un tube d'évacuation de concentré (230) s'étendent le long de l'axe de la structure rotative à usage unique. Une pompe centripète (208) pour le centrat est en communication fluidique avec le tube d'évacuation de centrat. Une pompe centripète (216) pour le concentré est en communication fluidique avec le tube d'évacuation de concentré. Un dispositif de commande (274) fonctionne en réponse à des capteurs (264, 270) dans des lignes d'évacuation de concentré et de centrat respectives (262, 268), pour commander les débits d'une pompe de concentré (272) et d'une pompe de centrat (266) pour produire des flux de sortie de concentré de cellules et un centrat généralement exempt de cellules.
CA3102600A 2018-06-08 2019-06-06 Systeme centrifuge pour separer des cellules en suspension Active CA3102600C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862682376P 2018-06-08 2018-06-08
US62/682,376 2018-06-08
PCT/US2019/035855 WO2019236895A1 (fr) 2018-06-08 2019-06-06 Système centrifuge pour séparer des cellules en suspension

Publications (2)

Publication Number Publication Date
CA3102600A1 CA3102600A1 (fr) 2019-12-12
CA3102600C true CA3102600C (fr) 2024-06-11

Family

ID=68770662

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3102600A Active CA3102600C (fr) 2018-06-08 2019-06-06 Systeme centrifuge pour separer des cellules en suspension

Country Status (8)

Country Link
EP (1) EP3801920A4 (fr)
JP (1) JP7336467B2 (fr)
KR (2) KR102568313B1 (fr)
CN (2) CN115254458A (fr)
AU (2) AU2019280856B2 (fr)
CA (1) CA3102600C (fr)
MX (2) MX2020011898A (fr)
WO (1) WO2019236895A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11878312B2 (en) * 2011-11-21 2024-01-23 Pneumatic Scale Corporation Centrifuge system for separating cells in suspension
US12350686B2 (en) * 2011-11-21 2025-07-08 Pneumatic Scale Corporation Centrifuge system for separating cells in suspension
US11065629B2 (en) * 2011-11-21 2021-07-20 Pneumatic Scale Corporation Centrifuge system for separating cells in suspension
US11957998B2 (en) * 2019-06-06 2024-04-16 Pneumatic Scale Corporation Centrifuge system for separating cells in suspension
AU2021335131A1 (en) * 2020-08-22 2023-04-06 Sunil Mehta An automated centrifugation device and methods to continuously separate components from different mixtures
CN112798393A (zh) * 2021-02-01 2021-05-14 中博瑞康（北京）生物技术有限公司 一种大体积生物细胞液浓缩洗涤系统及其方法
CN114682397B (zh) * 2022-03-28 2024-03-15 浙江大学 锥形液液轴向离心分离器及分离监控装置
IL316457A (en) * 2022-04-07 2024-12-01 Mirror Biologics Inc Artificial lymph node bioreactor

Family Cites Families (29)

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Publication number Priority date Publication date Assignee Title
CA894304A (en) * 1972-02-29 Fujisawa Mitsumaro Embossing film with compressed air on recessed drum and applying second film
GB675648A (en) * 1950-01-19 1952-07-16 Separator Ab Improved centrifugal separator for the continuous separation and discharge of solid matter from a liquid mixture
CA1057254A (fr) * 1976-05-14 1979-06-26 Baxter Travenol Laboratories Systeme jetable pour le centrifugeage du sang
DE3231070A1 (de) * 1982-08-19 1984-08-23 Herwig 1000 Berlin Michel-Kim Vorrichtung zur austragung von in silos gelagerten stoffen
ATE64863T1 (de) * 1986-07-22 1991-07-15 Haemonetics Corp Zentrifugengehaeuse oder rotor fuer plasmapherese.
US5318500A (en) * 1992-10-15 1994-06-07 Eli Lilly And Company Method for controlling intermittently discharged centrifuges
CH687505A5 (fr) * 1993-01-29 1996-12-31 Elp Rochat Séparateur centrifuge pour fluides.
US5637217A (en) * 1995-01-25 1997-06-10 Fleetguard, Inc. Self-driven, cone-stack type centrifuge
DE69618989T2 (de) * 1995-12-01 2002-09-26 Baker-Hughes Inc., Houston Verfahren und vorrichtung zum regeln und überwachen einer durchlaufzentrifuge
JPH09192215A (ja) * 1996-01-17 1997-07-29 Takaharu Nakane 遠心ボウル
JP3313572B2 (ja) * 1996-04-03 2002-08-12 ヘモネティクス・コーポレーション 血液処理用遠心分離器ボウル
DE19715661A1 (de) * 1997-04-16 1998-10-22 Mann & Hummel Filter Zentrifugenrotor
JP3817079B2 (ja) * 1998-10-05 2006-08-30 テルモ株式会社 血液成分採取装置
WO2000043096A1 (fr) * 1999-01-26 2000-07-27 Fluid Equipment Development Co., L.L.C. Chambre de traitement rotative equipee d'une pompe incorporee et d'une turbine de recuperation d'energie
US6629919B2 (en) * 1999-06-03 2003-10-07 Haemonetics Corporation Core for blood processing apparatus
EP1688183A1 (fr) * 2005-02-03 2006-08-09 Jean-Denis Rochat Procede et dispositif jetable pour la separation par centrifugation d'un liquide physiologique
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CN201094937Y (zh) * 2007-09-18 2008-08-06 江苏牡丹离心机制造有限公司 一种吊袋式离心机中的挤袋装置
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CN102387867B (zh) * 2008-12-29 2013-12-11 瓦格纳发展公司 具有一次性接触元件的固体排放离心式分离器
LT2438036T (lt) * 2009-06-04 2017-06-26 Genomatica, Inc. Fermentacijos sultinio komponentų išskyrimo būdas
EP2694217B1 (fr) * 2011-04-08 2018-07-18 Sorin Group Italia S.r.l. Appareil jetable pour séparation du sang par centrifugation
WO2015186057A1 (fr) * 2014-06-04 2015-12-10 Biosafe S.A. Système pour traitement multiple et séparation de fluides biologiques
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CN106238229B (zh) * 2016-08-31 2018-07-24 苏州盛天力离心机制造有限公司 抽滤离心机转鼓组件

Also Published As

Publication number Publication date
KR102568313B1 (ko) 2023-08-18
MX2022003223A (es) 2022-04-12
KR20210018796A (ko) 2021-02-18
CN115254458A (zh) 2022-11-01
CA3102600A1 (fr) 2019-12-12
CN112236236A (zh) 2021-01-15
EP3801920A1 (fr) 2021-04-14
AU2022204733A1 (en) 2022-07-21
WO2019236895A1 (fr) 2019-12-12
KR102568314B1 (ko) 2023-08-18
AU2019280856B2 (en) 2022-06-30
KR20220039841A (ko) 2022-03-29
JP7336467B2 (ja) 2023-08-31
AU2022204733B2 (en) 2024-07-04
JP2021526957A (ja) 2021-10-11
BR112020025083A2 (pt) 2021-03-23
AU2019280856A1 (en) 2020-12-17
EP3801920A4 (fr) 2022-07-13
MX2020011898A (es) 2021-01-15

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