CA3105541C - Derive de dimere de pyrrolobenzodiazepine reticule (pbd) et ses conjugues - Google Patents

Derive de dimere de pyrrolobenzodiazepine reticule (pbd) et ses conjugues

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Publication number
CA3105541C
CA3105541C CA3105541A CA3105541A CA3105541C CA 3105541 C CA3105541 C CA 3105541C CA 3105541 A CA3105541 A CA 3105541A CA 3105541 A CA3105541 A CA 3105541A CA 3105541 C CA3105541 C CA 3105541C
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CA
Canada
Prior art keywords
date
reçue
date received
cell
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3105541A
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English (en)
Other versions
CA3105541A1 (fr
Inventor
Robert Yongxin Zhao
Xiaotao ZHUO
Qingliang YANG
Linyao ZHAO
Yuanyuan Huang
Hangbo YE
Chengyu YANG
Jun Lei
Shun GAI
Huihui GUO
Junxiang JIA
Lu Bai
Hongsheng Xie
Xiaomai ZHOU
Zhixiang GUO
Wenjun Li
Mingjun CAO
Jun Zheng
Zhichang Ye
Yanlei YANG
Original Assignee
Hangzhou Dac Biotech Co Ltd
Filing date
Publication date
Application filed by Hangzhou Dac Biotech Co Ltd filed Critical Hangzhou Dac Biotech Co Ltd
Priority claimed from PCT/CN2018/094586 external-priority patent/WO2020006722A1/fr
Publication of CA3105541A1 publication Critical patent/CA3105541A1/fr
Application granted granted Critical
Publication of CA3105541C publication Critical patent/CA3105541C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Abstract

L'invention concerne un nouvel agent cytotoxique réticulé, des dérivés de dimère de pyrrolobenzo-diazépine (PBD), et leurs conjugués à une molécule de liaison cellulaire, un procédé de préparation des conjugués et l'utilisation thérapeutique de ces derniers.
CA3105541A 2018-07-05 Derive de dimere de pyrrolobenzodiazepine reticule (pbd) et ses conjugues Active CA3105541C (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2018/094586 WO2020006722A1 (fr) 2018-07-05 2018-07-05 Dérivé de dimère de pyrrolobenzodiazépine réticulé (pbd) et ses conjugués

Publications (2)

Publication Number Publication Date
CA3105541A1 CA3105541A1 (fr) 2020-01-09
CA3105541C true CA3105541C (fr) 2025-08-26

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