CA3113548C - Molecules bispecifiques de liaison a l'antigene comprenant un clone anti-fap 212 - Google Patents

Molecules bispecifiques de liaison a l'antigene comprenant un clone anti-fap 212

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Publication number
CA3113548C
CA3113548C CA3113548A CA3113548A CA3113548C CA 3113548 C CA3113548 C CA 3113548C CA 3113548 A CA3113548 A CA 3113548A CA 3113548 A CA3113548 A CA 3113548A CA 3113548 C CA3113548 C CA 3113548C
Authority
CA
Canada
Prior art keywords
seq
amino acid
acid sequence
antigen binding
bispecific antigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3113548A
Other languages
English (en)
Other versions
CA3113548A1 (fr
Inventor
Peter Bruenker
Harald Duerr
Christian Klein
Pablo Umana
Alexander BUJOTZEK
Joerg ZIELONKA
Christine TRUMPFHELLER
Moritz RAPP
Marine LE CLECH
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Priority claimed from PCT/EP2019/076375 external-priority patent/WO2020070041A1/fr
Publication of CA3113548A1 publication Critical patent/CA3113548A1/fr
Application granted granted Critical
Publication of CA3113548C publication Critical patent/CA3113548C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Abstract

L'invention concerne de nouvelles molécules bispécifiques de liaison à l'antigène, comprenant (a) au moins un domaine de liaison à l'antigène pouvant se lier spécifiquement à la protéine d'activation des fibroblastes (FAP) comprenant le clone FAP 212 ou des variants de celui-ci, et (b) au moins un domaine de liaison à l'antigène pouvant se lier spécifiquement à CD40, ainsi que des procédés de production de ces molécules et des procédés d'utilisation de ceux-ci.
CA3113548A 2018-10-01 2019-09-30 Molecules bispecifiques de liaison a l'antigene comprenant un clone anti-fap 212 Active CA3113548C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP18197866.9 2018-10-01
EP18197866 2018-10-01
PCT/EP2019/076375 WO2020070041A1 (fr) 2018-10-01 2019-09-30 Molécules bispécifiques de liaison à l'antigène comprenant un clone anti-fap 212

Publications (2)

Publication Number Publication Date
CA3113548A1 CA3113548A1 (fr) 2020-04-09
CA3113548C true CA3113548C (fr) 2026-01-20

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