CA3120103A1 - Compositions de fusosome pour administration a des lymphocytes t - Google Patents

Compositions de fusosome pour administration a des lymphocytes t Download PDF

Info

Publication number
CA3120103A1
CA3120103A1 CA3120103A CA3120103A CA3120103A1 CA 3120103 A1 CA3120103 A1 CA 3120103A1 CA 3120103 A CA3120103 A CA 3120103A CA 3120103 A CA3120103 A CA 3120103A CA 3120103 A1 CA3120103 A1 CA 3120103A1
Authority
CA
Canada
Prior art keywords
cell
fusosome
protein
fusogen
target cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3120103A
Other languages
English (en)
Inventor
Geoffrey A. Von Maltzahn
Jacob Rosenblum RUBENS
Albert Ruzo Matias
Ferdinando PUCCI
John Miles Milwid
Michael Travis MEE
Neal Francis GORDON
Jagesh Vijaykumar SHAH
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Flagship Pioneering Innovations V Inc
Original Assignee
Flagship Pioneering Innovations V Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Flagship Pioneering Innovations V Inc filed Critical Flagship Pioneering Innovations V Inc
Priority claimed from PCT/US2019/061434 external-priority patent/WO2020102503A2/fr
Publication of CA3120103A1 publication Critical patent/CA3120103A1/fr
Pending legal-status Critical Current

Links

Landscapes

  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne, au moins en partie, des procédés et des compositions pour une administration de fusosomes in vivo. Dans certains modes de réalisation, le fusosome comprend une combinaison d'éléments qui favorisent la spécificité pour des cellules cibles, par exemple, un ou plusieurs éléments parmi un fusogène, un élément régulateur spécifique d'une cellule cible positive et un élément régulateur spécifique d'une cellule non cible. Dans certains modes de réalisation, le fusosome comprend une ou plusieurs modifications qui diminuent une réponse immunitaire contre le fusosome.
CA3120103A 2018-11-14 2019-11-14 Compositions de fusosome pour administration a des lymphocytes t Pending CA3120103A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862767320P 2018-11-14 2018-11-14
US62/767,320 2018-11-14
US62/900,053 2019-09-13
PCT/US2019/061434 WO2020102503A2 (fr) 2018-11-14 2019-11-14 Compositions de fusosome pour administration à des lymphocytes t

Publications (1)

Publication Number Publication Date
CA3120103A1 true CA3120103A1 (fr) 2020-05-22

Family

ID=76206818

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3120103A Pending CA3120103A1 (fr) 2018-11-14 2019-11-14 Compositions de fusosome pour administration a des lymphocytes t

Country Status (1)

Country Link
CA (1) CA3120103A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111909961A (zh) * 2020-08-21 2020-11-10 华侨大学 一种CRISPR/Cas介导的ATL细胞基因编辑载体及其应用
CN113975299A (zh) * 2020-07-27 2022-01-28 上海市公共卫生临床中心 利用呼吸道上皮细胞膜防治呼吸道传染病的方法及应用
CN114045306A (zh) * 2021-11-10 2022-02-15 上海市食品药品检验研究院 一种反映免疫突触相关信号蛋白的荧光素酶互补系统质粒和稳转细胞株及其应用
CN115850482A (zh) * 2022-09-26 2023-03-28 北京华正博研科技有限公司 含有干细胞外泌体的皮肤光老化修复产品
CN116158402A (zh) * 2023-03-01 2023-05-26 中国人民解放军陆军军医大学第二附属医院 一种自发乳腺癌小鼠模型的构建方法
CN117467765A (zh) * 2023-10-31 2024-01-30 西南医科大学附属口腔医院 Fgf6在口腔黏膜癌变诊断、治疗中的应用
CN117487737A (zh) * 2023-12-26 2024-02-02 汕头大学 一种含Fe3O4纳米颗粒的去核细胞及其制备与在抗衰老中的应用

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113975299A (zh) * 2020-07-27 2022-01-28 上海市公共卫生临床中心 利用呼吸道上皮细胞膜防治呼吸道传染病的方法及应用
CN111909961A (zh) * 2020-08-21 2020-11-10 华侨大学 一种CRISPR/Cas介导的ATL细胞基因编辑载体及其应用
CN111909961B (zh) * 2020-08-21 2022-04-19 华侨大学 一种CRISPR/Cas介导的ATL细胞基因编辑载体及其应用
CN114045306A (zh) * 2021-11-10 2022-02-15 上海市食品药品检验研究院 一种反映免疫突触相关信号蛋白的荧光素酶互补系统质粒和稳转细胞株及其应用
CN114045306B (zh) * 2021-11-10 2024-03-19 上海市食品药品检验研究院 一种反映免疫突触相关信号蛋白的荧光素酶互补系统质粒和稳转细胞株及其应用
CN115850482A (zh) * 2022-09-26 2023-03-28 北京华正博研科技有限公司 含有干细胞外泌体的皮肤光老化修复产品
CN116158402A (zh) * 2023-03-01 2023-05-26 中国人民解放军陆军军医大学第二附属医院 一种自发乳腺癌小鼠模型的构建方法
CN116158402B (zh) * 2023-03-01 2025-05-30 中国人民解放军陆军军医大学第二附属医院 一种自发乳腺癌小鼠模型的构建方法
CN117467765A (zh) * 2023-10-31 2024-01-30 西南医科大学附属口腔医院 Fgf6在口腔黏膜癌变诊断、治疗中的应用
CN117487737A (zh) * 2023-12-26 2024-02-02 汕头大学 一种含Fe3O4纳米颗粒的去核细胞及其制备与在抗衰老中的应用
CN117487737B (zh) * 2023-12-26 2024-04-12 汕头大学 一种含Fe3O4纳米颗粒的去核细胞及其制备与在抗衰老中的应用

Similar Documents

Publication Publication Date Title
JP7815327B2 (ja) フソソーム組成物およびその使用
US20250369018A1 (en) Fusosome compositions and uses thereof
AU2019380517B2 (en) Fusosome compositions for hematopoietic stem cell delivery
US20230043255A1 (en) Fusosome compositions for t cell delivery
JP7676305B2 (ja) Ｃｎｓ送達のためのフソソーム組成物
CA3120103A1 (fr) Compositions de fusosome pour administration a des lymphocytes t
US20250059239A1 (en) Modified paramyxoviridae fusion glycoproteins
US20240279685A1 (en) Methods and compositions for producing viral fusosomes
JP2026074096A (ja) Ｔ細胞送達のためのフソソーム組成物
EP4698666A1 (fr) Fusogènes de protéine g universelle et systèmes adaptateurs de ceux-ci et particules lipidiques et utilisations associées

Legal Events

Date Code Title Description
MFA Maintenance fee for application paid

Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 5TH ANNIV.) - STANDARD

Year of fee payment: 5

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20241108

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT DETERMINED COMPLIANT

Effective date: 20241108

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20241108

D15 Examination report completed

Free format text: ST27 STATUS EVENT CODE: A-2-2-D10-D15-D126 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: EXAMINER'S REPORT

Effective date: 20241118

P11 Amendment of application requested

Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P11-P100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: AMENDMENT RECEIVED - RESPONSE TO EXAMINER'S REQUISITION

Effective date: 20250318

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-2-2-W10-W00-W111 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CORRESPONDENT DETERMINED COMPLIANT

Effective date: 20250321

P11 Amendment of application requested

Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P11-P102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: AMENDMENT DETERMINED COMPLIANT

Effective date: 20250715

P13 Application amended

Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P13-X000 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: APPLICATION AMENDED

Effective date: 20250715

P22 Classification modified

Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P22-P110 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CLASSIFICATION MODIFIED

Effective date: 20250904

MFA Maintenance fee for application paid

Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 6TH ANNIV.) - STANDARD

Year of fee payment: 6

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20251107

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20251107

D15 Examination report completed

Free format text: ST27 STATUS EVENT CODE: A-2-2-D10-D15-D126 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: EXAMINER'S REPORT

Effective date: 20260312