CA3121470C - Composes de pyrazolyle et leurs procedes d'utilisation - Google Patents

Composes de pyrazolyle et leurs procedes d'utilisation

Info

Publication number
CA3121470C
CA3121470C CA3121470A CA3121470A CA3121470C CA 3121470 C CA3121470 C CA 3121470C CA 3121470 A CA3121470 A CA 3121470A CA 3121470 A CA3121470 A CA 3121470A CA 3121470 C CA3121470 C CA 3121470C
Authority
CA
Canada
Prior art keywords
compound
pct
pyrazol
mmol
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3121470A
Other languages
English (en)
Other versions
CA3121470A1 (fr
Inventor
Hariprasad Vankayalapati
Original Assignee
ARRIEN PHARMACEUTICALS LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ARRIEN PHARMACEUTICALS LLC filed Critical ARRIEN PHARMACEUTICALS LLC
Priority claimed from PCT/US2019/058187 external-priority patent/WO2020087024A1/fr
Publication of CA3121470A1 publication Critical patent/CA3121470A1/fr
Application granted granted Critical
Publication of CA3121470C publication Critical patent/CA3121470C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Abstract

L'invention concerne également des composés ayant une activité en tant qu'agents chimiothérapeutiques. Les composés ont la structure suivante (I) : ou un sel, un stéréo-isomère, une forme isotopique ou un promédicament pharmaceutiquement acceptable de ceux-ci, où R1a, R1b, R1c, R1d, L, A, et b sont tels que définis dans la description. L'invention concerne également des procédés associés à la préparation et à l'utilisation de tels composés, des compositions pharmaceutiques comprenant de tels composés et des méthodes de traitement du cancer (par exemple, des cancers hématologiques).
CA3121470A 2018-10-26 2019-10-25 Composes de pyrazolyle et leurs procedes d'utilisation Active CA3121470C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862751405P 2018-10-26 2018-10-26
US62/751,405 2018-10-26
PCT/US2019/058187 WO2020087024A1 (fr) 2018-10-26 2019-10-25 Composés de pyrazolyle et leurs procédés d'utilisation

Publications (2)

Publication Number Publication Date
CA3121470A1 CA3121470A1 (fr) 2020-04-30
CA3121470C true CA3121470C (fr) 2025-07-29

Family

ID=

Similar Documents

Publication Publication Date Title
US20230105745A1 (en) Cycloalkyl and hetero-cycloalkyl inhibitors, preparation methods therefor, and use thereof
US20230135173A1 (en) Novel substituted quinoline-8-carbonitrile derivatives having androgen receptor degradation activity and uses thereof
US12006314B2 (en) Anti-cancer nuclear hormone receptor-targeting compounds
US11034669B2 (en) Pyrrole and pyrazole compounds and methods of use thereof
CN109970629A (zh) 抗真菌化合物的制备方法
EA026655B1 (ru) 6-ЗАМЕЩЕННЫЕ 3-(ХИНОЛИН-6-ИЛТИО)[1,2,4]ТРИАЗОЛО[4,3-a]ПИРИДИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ c-MET ТИРОЗИНКИНАЗЫ
US20230348475A1 (en) Imidazopyridazine and imidazopyrazine compounds as inhibitors of cdk7
JP2022501445A (ja) テルペノイド誘導体及びその用途
KR20180085814A (ko) 치환된 5,6-디히드로-6-페닐벤조[f]이소퀴놀린-2-아민의 제조 방법
US20250002472A1 (en) Pyridyl-containing compound
WO2020186196A1 (fr) Composés pyrazolo[1,5-a] pyrimidine trisubstitués utilisés en tant qu'inhibiteurs de cdk7
US20260055087A1 (en) Inhibitors of lrrk2 kinase
US11053221B2 (en) Substituted pyrimidines for inhibiting embryonic leucine zipper kinase activity
WO2022125613A1 (fr) Phosphonates en tant qu'inhibiteurs d'enpp1 et cdnp
CA3121470C (fr) Composes de pyrazolyle et leurs procedes d'utilisation
US11447463B2 (en) Piperidine carboxamide compound, preparation method, and use thereof
WO2022125614A1 (fr) Phosphonates comme inhibiteurs d'enpp1 et de cdnp
US20250275975A1 (en) Methods of Treating Neuropathies
CN117105872A (zh) 苯并二氮杂䓬类化合物及其制备方法与用途
HK1196353A (en) Compounds useful as inhibitors of choline kinase