CA3122191A1 - Composes et methodes de traitement du cancer de la tete et du cou - Google Patents

Composes et methodes de traitement du cancer de la tete et du cou Download PDF

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Publication number
CA3122191A1
CA3122191A1 CA3122191A CA3122191A CA3122191A1 CA 3122191 A1 CA3122191 A1 CA 3122191A1 CA 3122191 A CA3122191 A CA 3122191A CA 3122191 A CA3122191 A CA 3122191A CA 3122191 A1 CA3122191 A1 CA 3122191A1
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Canada
Prior art keywords
antibody
ilt2
amino acid
cells
seq
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Pending
Application number
CA3122191A
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English (en)
Inventor
Olivier BENAC
Stephanie Chanteux
Ivan PERROT
Benjamin Rossi
Nicolas VIAUD
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Innate Pharma SA
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Innate Pharma SA
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Publication of CA3122191A1 publication Critical patent/CA3122191A1/fr
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La présente invention concerne l'utilisation d'agents ciblant l'ILT-2 pour le traitement des cancers de la tête et du cou. La présente invention concerne également des schémas de combinaison avantageux destinés à être utilisés avec des agents ciblant l'IL-2 pour le traitement de cancers.
CA3122191A 2018-12-26 2019-12-20 Composes et methodes de traitement du cancer de la tete et du cou Pending CA3122191A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862784862P 2018-12-26 2018-12-26
US62/784,862 2018-12-26
PCT/EP2019/086861 WO2020136147A1 (fr) 2018-12-26 2019-12-20 Composés et méthodes de traitement du cancer de la tête et du cou

Publications (1)

Publication Number Publication Date
CA3122191A1 true CA3122191A1 (fr) 2020-07-02

Family

ID=69137898

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3120476A Pending CA3120476A1 (fr) 2018-12-26 2019-12-20 Anticorps neutralisant le recepteur de type immunoglobuline des leucocytes
CA3122191A Pending CA3122191A1 (fr) 2018-12-26 2019-12-20 Composes et methodes de traitement du cancer de la tete et du cou

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA3120476A Pending CA3120476A1 (fr) 2018-12-26 2019-12-20 Anticorps neutralisant le recepteur de type immunoglobuline des leucocytes

Country Status (8)

Country Link
US (2) US20220025056A1 (fr)
EP (2) EP3902828A1 (fr)
JP (3) JP2022516161A (fr)
CN (1) CN113330033B (fr)
AU (2) AU2019414793A1 (fr)
CA (2) CA3120476A1 (fr)
IL (1) IL284091A (fr)
WO (2) WO2020136147A1 (fr)

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WO2021074157A1 (fr) * 2019-10-14 2021-04-22 Innate Pharma Traitement du cancer avec des inhibiteurs d'ilt-2
EP4071172A4 (fr) 2019-12-23 2023-10-18 Lg Chem, Ltd. Anticorps anti-lilrb1 et ses utilisations
CA3186256A1 (fr) * 2020-07-28 2022-02-03 Yoon Aa Choi Anticorps anti-lilrb1 et ses utilisations
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EP4196227A2 (fr) * 2020-08-12 2023-06-21 Biond Biologics Ltd. Anticorps contre ilt2 et leur utilisation
CN114437214B (zh) * 2020-11-03 2023-06-02 南京北恒生物科技有限公司 靶向lir1的抗体及其用途
AU2022233201A1 (en) * 2021-03-11 2023-09-28 University Health Network Lilrb1 and lilrb2-binding molecules and uses therefor
IL315487A (en) * 2022-03-07 2024-11-01 Agenus Inc ANTI-ILT2 antibodies and their uses
WO2023170434A1 (fr) 2022-03-11 2023-09-14 Macomics Limited Compositions et procédés pour moduler l'activité des macrophages
WO2024207855A1 (fr) * 2023-04-04 2024-10-10 成都优洛生物科技有限公司 Anticorps anti-lilrb1 ou fragment de liaison à l'antigène de celui-ci, méthode de préparation et utilisation associées

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Also Published As

Publication number Publication date
AU2019414793A1 (en) 2021-06-24
EP3902828A1 (fr) 2021-11-03
CN113330033B (zh) 2024-11-29
JP2022516161A (ja) 2022-02-24
WO2020136145A2 (fr) 2020-07-02
WO2020136147A1 (fr) 2020-07-02
CN113330033A (zh) 2021-08-31
JP2022516140A (ja) 2022-02-24
AU2019412489A1 (en) 2021-06-10
EP3902829A2 (fr) 2021-11-03
CA3120476A1 (fr) 2020-07-02
IL284091A (en) 2021-08-31
JP2024054153A (ja) 2024-04-16
WO2020136145A3 (fr) 2020-08-13
US20220025056A1 (en) 2022-01-27
US20220025045A1 (en) 2022-01-27

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