CA3139011A1 - Lymphocytes t genetiquement modifies - Google Patents

Lymphocytes t genetiquement modifies Download PDF

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Publication number
CA3139011A1
CA3139011A1 CA3139011A CA3139011A CA3139011A1 CA 3139011 A1 CA3139011 A1 CA 3139011A1 CA 3139011 A CA3139011 A CA 3139011A CA 3139011 A CA3139011 A CA 3139011A CA 3139011 A1 CA3139011 A1 CA 3139011A1
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CA
Canada
Prior art keywords
polypeptide
domain
intracellular signaling
cell
transmembrane domain
Prior art date
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Pending
Application number
CA3139011A
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English (en)
Inventor
Jasdeep MANN
Christian ELLINGER
Daniel SOMMERMEYER
Benjamin BOYERINAS
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medigene Immunotherapies GmbH
2Seventy Bio Inc
Original Assignee
Medigene Immunotherapies GmbH
2Seventy Bio Inc
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Publication date
Application filed by Medigene Immunotherapies GmbH, 2Seventy Bio Inc filed Critical Medigene Immunotherapies GmbH
Publication of CA3139011A1 publication Critical patent/CA3139011A1/fr
Pending legal-status Critical Current

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • C07K—PEPTIDES
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
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    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
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    • C07—ORGANIC CHEMISTRY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
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    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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Abstract

La présente invention concerne des compositions destinées à des thérapies adoptives de lymphocytes T pour le traitement, la prévention ou l'amélioration d'au moins un symptôme d'un cancer, d'une maladie infectieuse, d'une maladie auto-immune, d'une maladie inflammatoire et d'une immunodéficience ou d'un état associé à ces dernières.
CA3139011A 2019-05-08 2020-05-07 Lymphocytes t genetiquement modifies Pending CA3139011A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962845311P 2019-05-08 2019-05-08
US62/845,311 2019-05-08
PCT/US2020/031796 WO2020227483A1 (fr) 2019-05-08 2020-05-07 Lymphocytes t génétiquement modifiés

Publications (1)

Publication Number Publication Date
CA3139011A1 true CA3139011A1 (fr) 2020-11-12

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ID=73051184

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3139011A Pending CA3139011A1 (fr) 2019-05-08 2020-05-07 Lymphocytes t genetiquement modifies

Country Status (16)

Country Link
US (1) US12590136B2 (fr)
EP (1) EP3966235A4 (fr)
JP (2) JP7723887B2 (fr)
KR (1) KR20220030933A (fr)
CN (2) CN120939220A (fr)
AU (1) AU2020267641B2 (fr)
BR (1) BR112021022303A2 (fr)
CA (1) CA3139011A1 (fr)
CL (1) CL2021002935A1 (fr)
CO (1) CO2021016480A2 (fr)
EA (1) EA202193074A1 (fr)
IL (1) IL287777A (fr)
MA (1) MA55911A (fr)
MX (1) MX2021013588A (fr)
SG (1) SG11202111973RA (fr)
WO (1) WO2020227483A1 (fr)

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GB201604458D0 (en) 2016-03-16 2016-04-27 Immatics Biotechnologies Gmbh Peptides and combination of peptides for use in immunotherapy against cancers
MA46862A (fr) 2016-11-17 2019-09-25 Bluebird Bio Inc Convertisseur de signaux tgf béta
DE102016123893A1 (de) 2016-12-08 2018-06-14 Immatics Biotechnologies Gmbh T-Zellrezeptoren mit verbesserter Bindung
EP3714941A1 (fr) 2019-03-27 2020-09-30 Medigene Immunotherapies GmbH Récepteurs de lymphocytes t de mage-a4
CA3139011A1 (fr) 2019-05-08 2020-11-12 Medigene Immunotherapies Gmbh Lymphocytes t genetiquement modifies
CA3177181A1 (fr) * 2020-03-27 2021-09-30 2Seventy Bio, Inc. Recepteurs de lymphocytes t
US20240366761A1 (en) * 2021-04-15 2024-11-07 Legend Biotech Ireland Limited Fusion proteins and uses thereof
TW202317602A (zh) * 2021-07-15 2023-05-01 福瑞德哈金森腫瘤中心 嵌合多肽
AU2022371471A1 (en) * 2021-10-20 2024-05-02 Fate Therapeutics, Inc. Effector cells and use thereof for allogeneic adoptive cell therapies in solid tumors
GB202115329D0 (en) * 2021-10-25 2021-12-08 Autolus Ltd Chimeric cytokine receptor
CN118922196A (zh) * 2022-02-18 2024-11-08 加利福尼亚大学董事会 嵌合细胞因子受体促进原代人nk细胞扩增和功能
USD1083734S1 (en) * 2022-08-01 2025-07-15 Hyundai Motor Company Wheel for automobile
EP4654981A1 (fr) * 2023-01-27 2025-12-03 Gentibio, Inc. Lymphocytes t régulateurs de réparation modifiés
WO2025047925A1 (fr) * 2023-08-31 2025-03-06 国立大学法人三重大学 Récepteur hybride de lymphocytes t

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AU2020267641B2 (en) 2026-04-09
MA55911A (fr) 2022-03-16
CN120939220A (zh) 2025-11-14
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US12590136B2 (en) 2026-03-31
US20230044580A1 (en) 2023-02-09
CN114375301B (zh) 2025-08-05
IL287777A (en) 2022-01-01
KR20220030933A (ko) 2022-03-11
CL2021002935A1 (es) 2022-08-05
CN114375301A (zh) 2022-04-19
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SG11202111973RA (en) 2021-11-29
EA202193074A1 (ru) 2022-03-21

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