CA3146912A1 - Procede d'elimination de cellules souches hematopoietique/progeniteurs hematopoietiques (csh/ph) chez un patient a l'aide d'anticorps bispecifiques - Google Patents

Procede d'elimination de cellules souches hematopoietique/progeniteurs hematopoietiques (csh/ph) chez un patient a l'aide d'anticorps bispecifiques Download PDF

Info

Publication number
CA3146912A1
CA3146912A1 CA3146912A CA3146912A CA3146912A1 CA 3146912 A1 CA3146912 A1 CA 3146912A1 CA 3146912 A CA3146912 A CA 3146912A CA 3146912 A CA3146912 A CA 3146912A CA 3146912 A1 CA3146912 A1 CA 3146912A1
Authority
CA
Canada
Prior art keywords
cells
antibody
antigen
cell
flt3
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3146912A
Other languages
English (en)
Inventor
Vladislav Sandler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hemogenyx Pharmaceuticals LLC
Original Assignee
Hemogenyx Pharmaceuticals LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US16/506,764 external-priority patent/US11104738B2/en
Application filed by Hemogenyx Pharmaceuticals LLC filed Critical Hemogenyx Pharmaceuticals LLC
Publication of CA3146912A1 publication Critical patent/CA3146912A1/fr
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Transplantation (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La présente invention concerne des compositions contenant des anticorps bispécifiques qui se lient à la protéine de récepteur de tyrosine kinase humaine FLT3/protéine de récepteur FLK2 et à une protéine de récepteur CD3 exprimée sur des lymphocytes T et l'utilisation des compositions contenant les anticorps bispécifiques dans la préparation d'un médicament destiné à éliminer des cellules souches hématopoïétiques/progéniteurs hématopoïétiques (CSH/PH) chez un patient.
CA3146912A 2019-07-09 2020-07-08 Procede d'elimination de cellules souches hematopoietique/progeniteurs hematopoietiques (csh/ph) chez un patient a l'aide d'anticorps bispecifiques Pending CA3146912A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16/506,764 2019-07-09
US16/506,764 US11104738B2 (en) 2016-04-04 2019-07-09 Monoclonal antibodies to human FLT3/FLK2 receptor protein
PCT/US2020/041095 WO2021007266A1 (fr) 2019-07-09 2020-07-08 Procédé d'élimination de cellules souches hématopoïétique/progéniteurs hématopoïétiques (csh/ph) chez un patient à l'aide d'anticorps bispécifiques

Publications (1)

Publication Number Publication Date
CA3146912A1 true CA3146912A1 (fr) 2021-01-14

Family

ID=74115143

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3146912A Pending CA3146912A1 (fr) 2019-07-09 2020-07-08 Procede d'elimination de cellules souches hematopoietique/progeniteurs hematopoietiques (csh/ph) chez un patient a l'aide d'anticorps bispecifiques

Country Status (5)

Country Link
EP (1) EP3997128A4 (fr)
JP (1) JP2022540602A (fr)
CN (1) CN114829399A (fr)
CA (1) CA3146912A1 (fr)
WO (1) WO2021007266A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4516807A1 (fr) 2023-08-28 2025-03-05 Consorcio Centro de Investigación Biomédica en Red Compositions destinées à être utilisées dans un procédé de fourniture d'une greffe améliorée de cellules souches hématopoïétiques

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104411720B (zh) * 2012-07-02 2018-05-11 协和发酵麒麟株式会社 以抗bmp9抗体作为有效成分的、对肾性贫血、癌性贫血等贫血的治疗剂
BR112017013981A2 (pt) * 2015-01-26 2018-01-02 Cellectis receptores antigênicos quiméricos com uma única cadeia específicos anti-cll1 (sccars) para imunoterapia de câncer
EP3268038B1 (fr) * 2015-03-09 2021-05-05 Agensys, Inc. Conjugués anticorps-médicament (cam) se liant aux protéines flt3
WO2016172026A1 (fr) * 2015-04-20 2016-10-27 The Board Of Regents Of The University Of Texas System Clec11a en tant qu'agent de croissance osseuse
WO2017176760A2 (fr) * 2016-04-04 2017-10-12 Vladislav Sandler Procédé d'élimination de cellules souches hématopoïétique/progéniteurs hématopoïétiques (csh/ph) chez un patient à l'aide d'anticorps bispécifiques
IL263744B2 (en) * 2016-06-17 2023-11-01 Magenta Therapeutics Inc Compositions and methods for the depletion of cd117 plus cells
CN109641051A (zh) * 2016-06-17 2019-04-16 美真达治疗公司 用于耗尽细胞的组合物和方法
US20200048618A1 (en) * 2017-04-18 2020-02-13 Autolus Limited Cell

Also Published As

Publication number Publication date
EP3997128A4 (fr) 2023-10-18
EP3997128A1 (fr) 2022-05-18
JP2022540602A (ja) 2022-09-16
CN114829399A (zh) 2022-07-29
WO2021007266A1 (fr) 2021-01-14

Similar Documents

Publication Publication Date Title
US11945866B2 (en) Method of eliminating hematopoietic stem cells/hematopoietic progenitors (HSC/HP) in a patient using bi-specific antibodies
US20220204935A1 (en) Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof
AU2020384369B2 (en) Anti-TCR antibody molecules and uses thereof
US11104738B2 (en) Monoclonal antibodies to human FLT3/FLK2 receptor protein
CN105873952A (zh) 经修饰的造血干细胞/祖细胞和非t效应细胞及其用途
JP2006528627A (ja) アロ反応性ナチュラルキラー細胞を使用する治療用抗体の有効性を増加するための方法および組成物
US20230218669A1 (en) Augmenting antigen-negative cell death in antigen-targeted immunotherapies
CA3146912A1 (fr) Procede d'elimination de cellules souches hematopoietique/progeniteurs hematopoietiques (csh/ph) chez un patient a l'aide d'anticorps bispecifiques
WO2022092277A1 (fr) Lymphocytes t-récepteur antigénique chimérique (car) exprimant le récepteur cxcl12
TW202216174A (zh) 使ｎｋ細胞與抗體之結合穩定化之方法及其利用
EP4378953A1 (fr) Fraction de ciblage de cd29 pour le traitement du cancer positif de cd29
CN118284621A (zh) 抗flt3抗体、car、car t细胞和使用方法
KR102919638B1 (ko) 자연살해세포 및 car-nk 세포의 제조 방법, 이에 따라 제조된 자연살해세포 및 car-nk 세포, 및 이의 용도
US20240216432A1 (en) Anti-flt3 antibodies, cars, car t cells and methods of use
TWI917318B (zh) 靶向ｄｌｌ３的嵌合抗原受體和結合劑
RU2828787C2 (ru) Способы получения аллогенных t-клеток с car
HK40074429A (en) Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof
HK40063038B (zh) 靶向dll3的嵌合抗原受体和结合剂
Han Engineering Chimeric Antigen Receptor T Cells towards Enhanced Safety and Efficacy in Cancer Immunotherapy

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20220907