CA3152329C - Amides heteroaryle-biphenyle pour le traitement de maladies associees a pd-l1 - Google Patents

Amides heteroaryle-biphenyle pour le traitement de maladies associees a pd-l1

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Publication number
CA3152329C
CA3152329C CA3152329A CA3152329A CA3152329C CA 3152329 C CA3152329 C CA 3152329C CA 3152329 A CA3152329 A CA 3152329A CA 3152329 A CA3152329 A CA 3152329A CA 3152329 C CA3152329 C CA 3152329C
Authority
CA
Canada
Prior art keywords
compound
methyl
group
dimethyl
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3152329A
Other languages
English (en)
Other versions
CA3152329A1 (fr
Inventor
Pingchen Fan
Christopher W. Lange
Rebecca M. LUI
Darren J. McMurtrie
Ryan J. SCAMP
Ju Yang
Penglie Zhang
Yibin Zeng
Original Assignee
Chemocentryx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemocentryx Inc filed Critical Chemocentryx Inc
Priority claimed from PCT/US2020/055672 external-priority patent/WO2021076691A1/fr
Publication of CA3152329A1 publication Critical patent/CA3152329A1/fr
Application granted granted Critical
Publication of CA3152329C publication Critical patent/CA3152329C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Abstract

L'invention concerne des composés qui sont utiles en tant qu'immunomodulateurs. Les composés, y compris des stéréoisomères et des sels pharmaceutiquement acceptables de ceux-ci, présentent la formule (I), dans laquelle R<sup>2a</sup>, R<sup>2b</sup>, R<sup>3</sup>, R<sup>3a</sup>, R<sup>4</sup>, R<sup>6</sup>, R<sup>7</sup>, R<sup>8</sup>, A, Z, X<sup>1</sup> et n sont tels que définis dans la description. L'invention concerne également des procédés associés à la préparation et à l'utilisation de tels composés, ainsi que des compositions pharmaceutiques comprenant de tels composés.
CA3152329A 2019-10-16 2020-10-15 Amides heteroaryle-biphenyle pour le traitement de maladies associees a pd-l1 Active CA3152329C (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962915779P 2019-10-16 2019-10-16
US62/915,779 2019-10-16
US202063042796P 2020-06-23 2020-06-23
US63/042,796 2020-06-23
US202063057460P 2020-07-28 2020-07-28
US63/057,460 2020-07-28
PCT/US2020/055672 WO2021076691A1 (fr) 2019-10-16 2020-10-15 Amides hétéroaryle-biphényle pour le traitement de maladies associées à pd-l1

Publications (2)

Publication Number Publication Date
CA3152329A1 CA3152329A1 (fr) 2021-04-22
CA3152329C true CA3152329C (fr) 2026-03-10

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