CA3170773C - Composes heterocycliques pour inhiber des activites de tyk2 - Google Patents

Composes heterocycliques pour inhiber des activites de tyk2

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Publication number
CA3170773C
CA3170773C CA3170773A CA3170773A CA3170773C CA 3170773 C CA3170773 C CA 3170773C CA 3170773 A CA3170773 A CA 3170773A CA 3170773 A CA3170773 A CA 3170773A CA 3170773 C CA3170773 C CA 3170773C
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CA
Canada
Prior art keywords
compound
mmol
methyl
tyk2
methoxy
Prior art date
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CA3170773A
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English (en)
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CA3170773A1 (fr
Inventor
Xiangyang Chen
Yucheng Pang
Original Assignee
Beijing Innocare Pharma Tech Co Ltd
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Application filed by Beijing Innocare Pharma Tech Co Ltd filed Critical Beijing Innocare Pharma Tech Co Ltd
Priority claimed from PCT/CN2021/079752 external-priority patent/WO2021180072A1/fr
Publication of CA3170773A1 publication Critical patent/CA3170773A1/fr
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Publication of CA3170773C publication Critical patent/CA3170773C/fr
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Abstract

L'invention concerne des composés 1-8, et leurs sels ou promédicaments pharmaceutiquement acceptables. Les composés 1-8 sont des liants sélectifs vis-à-vis de JH2 de TYK2 et présentent des effets inhibiteurs significatifs sur la fonction physiologique de TYK2 et ils présentent d'excellentes propriétés pharmacocinétiques in vivo. Les composés 1-5 et 7 ont plusieurs substitutions de deutérium sur le méthyle pour améliorer les propriétés pharmacocinétiques (PK).
CA3170773A 2020-03-11 2021-03-09 Composes heterocycliques pour inhiber des activites de tyk2 Active CA3170773C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062988317P 2020-03-11 2020-03-11
US62/988,317 2020-03-11
PCT/CN2021/079752 WO2021180072A1 (fr) 2020-03-11 2021-03-09 Composés hétérocycliques pour inhiber des activités de tyk2

Publications (2)

Publication Number Publication Date
CA3170773A1 CA3170773A1 (fr) 2021-09-16
CA3170773C true CA3170773C (fr) 2026-02-10

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