CA3177108A1 - Detection et modification de la population microbienne intestinale - Google Patents

Detection et modification de la population microbienne intestinale Download PDF

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Publication number
CA3177108A1
CA3177108A1 CA3177108A CA3177108A CA3177108A1 CA 3177108 A1 CA3177108 A1 CA 3177108A1 CA 3177108 A CA3177108 A CA 3177108A CA 3177108 A CA3177108 A CA 3177108A CA 3177108 A1 CA3177108 A1 CA 3177108A1
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CA
Canada
Prior art keywords
indole
fluid samples
acid
microbiome
tryptophan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3177108A
Other languages
English (en)
Inventor
Wayne R. Matson
Samantha A. Matson
Erika N. Angle
Srikant Sarangi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ixcela Inc
Original Assignee
Ixcela Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US16/859,453 external-priority patent/US11041847B1/en
Application filed by Ixcela Inc filed Critical Ixcela Inc
Publication of CA3177108A1 publication Critical patent/CA3177108A1/fr
Pending legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6806—Determination of free amino acids
    • G01N33/6812—Assays for specific amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne des méthodes et des systèmes pour évaluer l'état de santé/maladie d'un individu. En particulier, la divulgation concerne des méthodes pour mesurer des niveaux d'un ou plusieurs métabolites d'intérêt chez un individu et utiliser ces mesures afin d'évaluer la santé de l'individu. La divulgation concerne également des systèmes pour mettre en ?uvre les méthodes divulguées. Par exemple, les systèmes divulgués peuvent comprendre un module d'évaluation de niveau de métabolite pour déterminer la santé de l'individu sur la base des niveaux de métabolite mesurés.
CA3177108A 2020-04-27 2021-04-27 Detection et modification de la population microbienne intestinale Pending CA3177108A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16/859,453 2020-04-27
US16/859,453 US11041847B1 (en) 2019-01-25 2020-04-27 Detection and modification of gut microbial population
PCT/US2021/029475 WO2021222309A1 (fr) 2020-04-27 2021-04-27 Détection et modification de la population microbienne intestinale

Publications (1)

Publication Number Publication Date
CA3177108A1 true CA3177108A1 (fr) 2021-11-04

Family

ID=78332179

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3177108A Pending CA3177108A1 (fr) 2020-04-27 2021-04-27 Detection et modification de la population microbienne intestinale

Country Status (2)

Country Link
CA (1) CA3177108A1 (fr)
WO (1) WO2021222309A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114062573A (zh) * 2021-12-22 2022-02-18 重庆医科大学国际体外诊断研究院 一种同时检测大鼠血浆中四种吲哚类物质的高效液相色谱法
CN114216989A (zh) * 2021-12-23 2022-03-22 重庆医科大学国际体外诊断研究院 高效液相色谱法检测血浆吲哚类物质的试剂盒及其应用
CN116656851B (zh) * 2023-07-28 2023-10-24 广东省科学院生物与医学工程研究所 一种生物标志物及其在慢性阻塞性肺疾病诊断方面的应用
CN118141804A (zh) * 2024-03-06 2024-06-07 浙江大学 吲哚-3-丙酸在制备用于增敏肿瘤免疫治疗的药物中的用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2987582T3 (es) * 2013-01-31 2024-11-15 Metabolon Inc Biomarcadores relacionados con la progresión de la resistencia a la Insulina y métodos que lo utilizan
WO2018094204A1 (fr) * 2016-11-17 2018-05-24 Arivale, Inc. Détermination de relations entre des risques pour des états biologiques et des analytes dynamiques
WO2018136884A1 (fr) * 2017-01-23 2018-07-26 The Regents Of The University Of California Compositions et procédés de traitement de l'obésité et d'induction de perte de poids
EP3681521A4 (fr) * 2017-09-13 2021-05-19 Evolve Biosystems Inc. Révision métabolomique de nourrissons mammifères
WO2019178542A1 (fr) * 2018-03-16 2019-09-19 Persephone Biome, Inc. Compositions pour moduler des populations de microflore intestinale, améliorer l'efficacité de médicaments et traiter le cancer, leurs procédés de fabrication et leurs méthodes d'utilisation
US11041847B1 (en) * 2019-01-25 2021-06-22 Ixcela, Inc. Detection and modification of gut microbial population
IL264581A (en) * 2019-01-31 2020-08-31 Segal Eran Predicting blood metabolites

Also Published As

Publication number Publication date
WO2021222309A1 (fr) 2021-11-04

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