CA3178640A1 - Ligands fonctionnels vis-a-vis d'une proteine de spicule de sars-cov-2 - Google Patents

Ligands fonctionnels vis-a-vis d'une proteine de spicule de sars-cov-2 Download PDF

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Publication number
CA3178640A1
CA3178640A1 CA3178640A CA3178640A CA3178640A1 CA 3178640 A1 CA3178640 A1 CA 3178640A1 CA 3178640 A CA3178640 A CA 3178640A CA 3178640 A CA3178640 A CA 3178640A CA 3178640 A1 CA3178640 A1 CA 3178640A1
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CA
Canada
Prior art keywords
target
nucleic acid
sequence
binding
library
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3178640A
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English (en)
Inventor
George Jackson
Garam LEE
Rafal DRABEK
Alexander CHIU
Jasmine KUAR
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Base Pair Biotechnologies Inc
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Base Pair Biotechnologies Inc
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Publication date
Application filed by Base Pair Biotechnologies Inc filed Critical Base Pair Biotechnologies Inc
Publication of CA3178640A1 publication Critical patent/CA3178640A1/fr
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/16—Aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/10—Applications; Uses in screening processes
    • C12N2320/13—Applications; Uses in screening processes in a process of directed evolution, e.g. SELEX, acquiring a new function

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La présente invention concerne des ligands fonctionnels pour cibler des molécules, en particulier des acides nucléiques fonctionnels et des modifications de ceux-ci, et des procédés pour générer simultanément, par exemple, de nombreuses biomolécules fonctionnelles différentes, en particulier des procédés pour générer de nombreux acides nucléiques fonctionnels différents contre de multiples molécules cibles simultanément. La présente invention concerne en outre des ligands fonctionnels qui se lient à des cibles, telles que des virus (par ex., le coronavirus du syndrome respiratoire aigu sévère 2 (SARS-CoV-2)) et/ou des antigènes de celui-ci (par ex., une protéine de spicule et/ou ses sous-unités).
CA3178640A 2020-05-12 2021-05-25 Ligands fonctionnels vis-a-vis d'une proteine de spicule de sars-cov-2 Pending CA3178640A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063023816P 2020-05-12 2020-05-12
US63/023,816 2020-05-12
US202063066417P 2020-08-17 2020-08-17
US63/066,417 2020-08-17
PCT/US2021/034037 WO2021232028A1 (fr) 2020-05-12 2021-05-25 Ligands fonctionnels vis-à-vis d'une protéine de spicule de sars-cov-2

Publications (1)

Publication Number Publication Date
CA3178640A1 true CA3178640A1 (fr) 2021-11-18

Family

ID=78525096

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3178640A Pending CA3178640A1 (fr) 2020-05-12 2021-05-25 Ligands fonctionnels vis-a-vis d'une proteine de spicule de sars-cov-2

Country Status (2)

Country Link
CA (1) CA3178640A1 (fr)
WO (1) WO2021232028A1 (fr)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040029129A1 (en) * 2001-10-25 2004-02-12 Liangsu Wang Identification of essential genes in microorganisms
CA3114302A1 (fr) * 2018-09-28 2020-04-02 Augmanity Nano Ltd Procedes et compositions pour la selection d'aptameres fonctionnels

Also Published As

Publication number Publication date
WO2021232028A1 (fr) 2021-11-18

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