CA3189923C - Procedes et compositions pour la production de produits derives d'acetyl-coa - Google Patents

Procedes et compositions pour la production de produits derives d'acetyl-coa

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Publication number
CA3189923C
CA3189923C CA3189923A CA3189923A CA3189923C CA 3189923 C CA3189923 C CA 3189923C CA 3189923 A CA3189923 A CA 3189923A CA 3189923 A CA3189923 A CA 3189923A CA 3189923 C CA3189923 C CA 3189923C
Authority
CA
Canada
Prior art keywords
genetically modified
modified microorganism
microorganism
gene
pyruvate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3189923A
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English (en)
Other versions
CA3189923A1 (fr
Inventor
Michael David Lynch
Shaui Li
Original Assignee
Duke University
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Publication date
Application filed by Duke University filed Critical Duke University
Priority claimed from PCT/US2021/043023 external-priority patent/WO2022020748A1/fr
Publication of CA3189923A1 publication Critical patent/CA3189923A1/fr
Application granted granted Critical
Publication of CA3189923C publication Critical patent/CA3189923C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Abstract

L'invention concerne des souches microbiennes génétiquement modifiées et des bioprocédés associés pour la production de produits dérivés d'acétyl-CoA. Spécifiquement, l'utilisation de valvules métaboliques synthétiques à commande dynamique pour réduire l'activité de certaines enzymes, conduit à une production accrue de produit dans un procédé en deux étapes.
CA3189923A 2020-07-24 2021-07-23 Procedes et compositions pour la production de produits derives d'acetyl-coa Active CA3189923C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063056031P 2020-07-24 2020-07-24
US63/056,031 2020-07-24
PCT/US2021/043023 WO2022020748A1 (fr) 2020-07-24 2021-07-23 Procédés et compositions pour la production de produits dérivés d'acétyl-coa

Publications (2)

Publication Number Publication Date
CA3189923A1 CA3189923A1 (fr) 2022-01-27
CA3189923C true CA3189923C (fr) 2025-12-02

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