CA3196145A1 - Compounds and methods for the treatment of ocular disorders - Google Patents

Compounds and methods for the treatment of ocular disorders

Info

Publication number
CA3196145A1
CA3196145A1 CA3196145A CA3196145A CA3196145A1 CA 3196145 A1 CA3196145 A1 CA 3196145A1 CA 3196145 A CA3196145 A CA 3196145A CA 3196145 A CA3196145 A CA 3196145A CA 3196145 A1 CA3196145 A1 CA 3196145A1
Authority
CA
Canada
Prior art keywords
substituted
alkyl
radical
heteroalkyl
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3196145A
Other languages
English (en)
French (fr)
Inventor
Ian Holmes
Yair Alster
Hila Barash
Charles Bosworth
Omer Rafaeli
Robert M. Burk
Marc GLEESON
Mark Richard Stewart
Jonathan DUNN
Alexander James Nicholls
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Azura Ophthalmics Ltd
Original Assignee
Azura Ophthalmics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Azura Ophthalmics Ltd filed Critical Azura Ophthalmics Ltd
Publication of CA3196145A1 publication Critical patent/CA3196145A1/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
CA3196145A 2020-10-21 2021-10-20 Compounds and methods for the treatment of ocular disorders Pending CA3196145A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063094793P 2020-10-21 2020-10-21
US63/094,793 2020-10-21
US202163170988P 2021-04-05 2021-04-05
US63/170,988 2021-04-05
PCT/IB2021/000707 WO2022084738A2 (en) 2020-10-21 2021-10-20 Compounds and methods for the treatment of ocular disorders

Publications (1)

Publication Number Publication Date
CA3196145A1 true CA3196145A1 (en) 2022-04-28

Family

ID=81291739

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3196145A Pending CA3196145A1 (en) 2020-10-21 2021-10-20 Compounds and methods for the treatment of ocular disorders

Country Status (8)

Country Link
EP (1) EP4232149A4 (de)
JP (1) JP2023546453A (de)
KR (1) KR20230110515A (de)
AU (1) AU2021363702A1 (de)
CA (1) CA3196145A1 (de)
IL (1) IL302173A (de)
MX (1) MX2023004537A (de)
WO (1) WO2022084738A2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20220003555A (ko) 2019-04-18 2022-01-10 아주라 오프탈믹스 엘티디 안구 장애의 치료를 위한 화합물 및 방법
US11459351B1 (en) 2021-04-05 2022-10-04 Azura Ophthalmics Ltd. Compounds and methods for the treatment of ocular disorders
WO2024100454A2 (en) * 2022-11-11 2024-05-16 Azura Ophthalmics Ltd. Composition and methods for improving signs and symptoms of ocular disorders

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003070173A2 (en) * 2002-02-15 2003-08-28 Sympore Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
JP2014518275A (ja) * 2011-06-29 2014-07-28 インサイト・ビジョン・インコーポレイテッド 再発性マイボーム腺障害の処置方法およびそれによる再発頻度の減少方法
WO2018161039A1 (en) * 2017-03-03 2018-09-07 Synovo Gmbh Novel anti-infective and anti-inflammatory compounds
WO2018215638A1 (en) * 2017-05-26 2018-11-29 Novaliq Gmbh Pharmaceutical compositions comprising azithromycin
AU2020259997B2 (en) * 2019-04-18 2025-08-07 Azura Ophthalmics Ltd. Compounds and methods for the treatment of ocular disorders

Also Published As

Publication number Publication date
IL302173A (en) 2023-06-01
AU2021363702A1 (en) 2023-06-15
EP4232149A4 (de) 2024-12-11
WO2022084738A2 (en) 2022-04-28
WO2022084738A3 (en) 2022-06-30
JP2023546453A (ja) 2023-11-02
AU2021363702A9 (en) 2024-02-08
KR20230110515A (ko) 2023-07-24
EP4232149A2 (de) 2023-08-30
MX2023004537A (es) 2023-06-15

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