CA3224558A1 - Utilisation d'un compose arylique polycyclique dans la preparation d'un medicament antifongique - Google Patents

Utilisation d'un compose arylique polycyclique dans la preparation d'un medicament antifongique Download PDF

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Publication number
CA3224558A1
CA3224558A1 CA3224558A CA3224558A CA3224558A1 CA 3224558 A1 CA3224558 A1 CA 3224558A1 CA 3224558 A CA3224558 A CA 3224558A CA 3224558 A CA3224558 A CA 3224558A CA 3224558 A1 CA3224558 A1 CA 3224558A1
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CA
Canada
Prior art keywords
compound
polycyclic aromatic
pharmaceutically acceptable
candida
aromatic compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3224558A
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English (en)
Inventor
Hong Zhang
Wencai Ye
Yishan ZHANG
Lijun Hu
Shuixiu LI
Yajing Zhao
Chuanyan TANG
Luobang WENG
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
First Affiliated Hospital Of Jinan University
Original Assignee
First Affiliated Hospital Of Jinan University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by First Affiliated Hospital Of Jinan University filed Critical First Affiliated Hospital Of Jinan University
Publication of CA3224558A1 publication Critical patent/CA3224558A1/fr
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/194—Radicals derived from thio- or thiono carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne un composé arylique polycyclique S1 pour la préparation d'un médicament contre une infection fongique. La formule développée du composé polycyclique est S1. Le composé arylique polycyclique présentant la structure noyau-enveloppe et représenté par S1 dans la présente invention est approprié pour la préparation de médicaments contre les infections fongiques pathogènes à Candida, Aspergillus, Mucor et autres, et présente les effets bénéfiques suivants : le composé S1 de la présente demande a un effet antifongique à large spectre contre les champignons pathogènes comprenant, entre autres, Candida, Aspergillus, Mucor, etc., est efficace contre les Candida résistant à l'azole, présente une faible toxicité vis-à-vis des mammifères, et permet de traiter une infection fongique systémique par administration orale, et peut également être utilisé localement pour traiter une infection à Candida des muqueuses.
CA3224558A 2021-07-15 2022-05-24 Utilisation d'un compose arylique polycyclique dans la preparation d'un medicament antifongique Pending CA3224558A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN202110803698.0 2021-07-15
CN202110803698.0A CN113956215B (zh) 2021-07-15 2021-07-15 一种多环芳基化合物在抗真菌药物制备中的应用
PCT/CN2022/094745 WO2023284420A1 (fr) 2021-07-15 2022-05-24 Utilisation d'un composé arylique polycyclique dans la préparation d'un médicament antifongique

Publications (1)

Publication Number Publication Date
CA3224558A1 true CA3224558A1 (fr) 2023-01-19

Family

ID=79460381

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3224558A Pending CA3224558A1 (fr) 2021-07-15 2022-05-24 Utilisation d'un compose arylique polycyclique dans la preparation d'un medicament antifongique

Country Status (3)

Country Link
CN (1) CN113956215B (fr)
CA (1) CA3224558A1 (fr)
WO (1) WO2023284420A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113956215B (zh) * 2021-07-15 2022-08-12 暨南大学附属第一医院 一种多环芳基化合物在抗真菌药物制备中的应用
CN116473985B (zh) * 2023-03-29 2024-12-10 暨南大学 一种多烯类抗真菌药物组合物及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009086303A2 (fr) * 2007-12-21 2009-07-09 University Of Rochester Procédé permettant de modifier la durée de vie d'organismes eucaryotes
CN108947985A (zh) * 2017-05-22 2018-12-07 苏州偶领生物医药有限公司 用作自噬调节剂的化合物及其制备方法和用途
CN113956215B (zh) * 2021-07-15 2022-08-12 暨南大学附属第一医院 一种多环芳基化合物在抗真菌药物制备中的应用

Also Published As

Publication number Publication date
CN113956215A (zh) 2022-01-21
WO2023284420A1 (fr) 2023-01-19
CN113956215B (zh) 2022-08-12

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