CA3225639A1 - Systeme de reacteur et ses procedes d'utilisation - Google Patents

Systeme de reacteur et ses procedes d'utilisation Download PDF

Info

Publication number
CA3225639A1
CA3225639A1 CA3225639A CA3225639A CA3225639A1 CA 3225639 A1 CA3225639 A1 CA 3225639A1 CA 3225639 A CA3225639 A CA 3225639A CA 3225639 A CA3225639 A CA 3225639A CA 3225639 A1 CA3225639 A1 CA 3225639A1
Authority
CA
Canada
Prior art keywords
chamber
chambers
minutes
cartridge
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3225639A
Other languages
English (en)
Inventor
Jose Castillo
Kristof VANDEKERCKHOVE
Sebastien Rodriguez
Bastien MAIRESSE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Quantoom Biosciences SA
Original Assignee
Quantoom Biosciences SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from BE20215657A external-priority patent/BE1029694B1/fr
Priority claimed from US17/854,536 external-priority patent/US20230011323A1/en
Application filed by Quantoom Biosciences SA filed Critical Quantoom Biosciences SA
Publication of CA3225639A1 publication Critical patent/CA3225639A1/fr
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/42—Integrated assemblies, e.g. cassettes or cartridges
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Computer Hardware Design (AREA)
  • Clinical Laboratory Science (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'invention concerne des systèmes, des procédés et des dispositifs pour la production et le traitement en continu de composés, y compris de composés biopharmaceutiques. Le système et les dispositifs sont actionnés de manière automatisée et peuvent fonctionner dans des conditions conformes aux bonnes pratiques de fabrication (BPF).
CA3225639A 2021-07-01 2022-07-01 Systeme de reacteur et ses procedes d'utilisation Pending CA3225639A1 (fr)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US202163217680P 2021-07-01 2021-07-01
US63/217,680 2021-07-01
BE20215657A BE1029694B1 (fr) 2021-08-18 2021-08-18 Système de réacteur et méthodes pour l'utilisation de celui-ci
BE2021/5657 2021-08-18
US202263331568P 2022-04-15 2022-04-15
US63/331,568 2022-04-15
US17/854,536 US20230011323A1 (en) 2021-07-01 2022-06-30 Reactor system and methods for using thereof
US17/854,536 2022-06-30
PCT/EP2022/068259 WO2023275355A1 (fr) 2021-07-01 2022-07-01 Système de réacteur et ses procédés d'utilisation

Publications (1)

Publication Number Publication Date
CA3225639A1 true CA3225639A1 (fr) 2023-01-05

Family

ID=82214440

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3225639A Pending CA3225639A1 (fr) 2021-07-01 2022-07-01 Systeme de reacteur et ses procedes d'utilisation

Country Status (8)

Country Link
EP (1) EP4363551A1 (fr)
JP (1) JP2024526249A (fr)
KR (1) KR20240029771A (fr)
AU (1) AU2022301719A1 (fr)
CA (1) CA3225639A1 (fr)
IL (1) IL309834A (fr)
TW (1) TW202321432A (fr)
WO (1) WO2023275355A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025106776A1 (fr) * 2023-11-17 2025-05-22 Amgen Inc. Systèmes et procédés d'évaluation améliorée de molécules

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI885664B (zh) * 2023-12-27 2025-06-01 南亞塑膠工業股份有限公司 細胞培養袋

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018031769A1 (fr) * 2016-08-10 2018-02-15 Lonza Inc. Examen de recettes de lots biopharmaceutiques par exception
EP3714035A4 (fr) * 2017-11-22 2021-08-18 Culture Biosciences, Inc. Cellule de travail d'automatisation de fermentation
US10689669B1 (en) * 2020-01-11 2020-06-23 Inscripta, Inc. Automated multi-module cell processing methods, instruments, and systems

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025106776A1 (fr) * 2023-11-17 2025-05-22 Amgen Inc. Systèmes et procédés d'évaluation améliorée de molécules

Also Published As

Publication number Publication date
WO2023275355A1 (fr) 2023-01-05
AU2022301719A1 (en) 2024-02-15
TW202321432A (zh) 2023-06-01
EP4363551A1 (fr) 2024-05-08
IL309834A (en) 2024-02-01
JP2024526249A (ja) 2024-07-17
KR20240029771A (ko) 2024-03-06

Similar Documents

Publication Publication Date Title
US20230011323A1 (en) Reactor system and methods for using thereof
CN112334579B (zh) 用于rna体外转录的生物反应器
Perry et al. Lentiviral vector bioprocessing
Lin et al. Digital loop-mediated isothermal amplification on a commercial membrane
Xie et al. Engineering SARS-CoV-2 using a reverse genetic system
Duarte et al. Bacterial microcolonies in gel beads for high-throughput screening of libraries in synthetic biology
CA3225639A1 (fr) Systeme de reacteur et ses procedes d'utilisation
Thomassen et al. Scale‐down of the inactivated polio vaccine production process
Gränicher et al. Production of modified Vaccinia Ankara virus by intensified cell cultures: a comparison of platform technologies for viral vector production
JP7721453B2 (ja) マルチパラレルバイオリアクター中で接着性細胞を培養するための方法
Kaiser et al. Single-use bioreactors for animal and human cells
Sloth et al. Analysis of compositional bias in a commercial phage display peptide library by next-generation sequencing
Srinivasan et al. Circular RNA formation and degradation are not directed by universal pathways
Vitalis et al. Leveraging interactions in microfluidic droplets for enhanced biotechnology screens
Ladd et al. Proof-of-concept of continuous transfection for adeno-associated virus production in microcarrier-based culture
Yang et al. Development of an integrated continuous manufacturing process for the rVSV-vectored SARS-CoV-2 candidate vaccine
Chaves et al. Evaluation of commercial RNA extraction protocols for avian influenza virus using nanopore metagenomic sequencing
Wang et al. Detection of porcine circovirus (PCV) using CRISPR-Cas12a/13a coupled with isothermal amplification
Podgornik et al. Continuous production of bacteriophages
CN117795054A (zh) 反应器系统及其使用方法
BE1029694B1 (fr) Système de réacteur et méthodes pour l'utilisation de celui-ci
Pang et al. Evaluation of the Robustness Verification of Downstream Production Process for Inactivated SARS-CoV-2 Vaccine and Different Chromatography Medium Purification Effects
WO2024141622A1 (fr) Procédé et dispositif de mise en œuvre en continu d'une réaction biochimique liquide
Kang et al. Accurate diagnosis of COVID-19 from self-collectable biospecimens using synthetic apolipoprotein H peptide-coated nanoparticle assay
Patel et al. Developing an effective scale-down model for a suspension adapted HEK293T-derived lentiviral vector stable producer cell line

Legal Events

Date Code Title Description
W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-1-1-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT

Effective date: 20251231