CA3240875A1 - Variants de proteine de surface cellulaire discernable de cd45 destines a etre utilises en therapie cellulaire - Google Patents

Variants de proteine de surface cellulaire discernable de cd45 destines a etre utilises en therapie cellulaire Download PDF

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Publication number
CA3240875A1
CA3240875A1 CA3240875A CA3240875A CA3240875A1 CA 3240875 A1 CA3240875 A1 CA 3240875A1 CA 3240875 A CA3240875 A CA 3240875A CA 3240875 A CA3240875 A CA 3240875A CA 3240875 A1 CA3240875 A1 CA 3240875A1
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CA
Canada
Prior art keywords
seq
isoform
cell
cells
amino acid
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3240875A
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English (en)
Inventor
Stefanie Urlinger
Lukas JEKER
Rosalba LEPORE
Romina MATTER MARONE
Anna CAMUS
Alessandro Sinopoli
Izabela DURZYNSKA
Anna HAYDN
Anna DEVAUX
Simon GARAUDE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cimeio Therapeutics Ag
University of Basel
Original Assignee
Cimeio Therapeutics Ag
University of Basel
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Filing date
Publication date
Application filed by Cimeio Therapeutics Ag, University of Basel filed Critical Cimeio Therapeutics Ag
Publication of CA3240875A1 publication Critical patent/CA3240875A1/fr
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70589—CD45
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/289—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD45
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Oncology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente divulgation concerne l'utilisation de cellules comprenant une protéine de surface discernable à une ou plusieurs mutations naturelles ou résultant d'une modification mais aussi une protéine de surface fonctionnelle à utiliser en thérapie. La présente invention concerne également l'utilisation de cellules comprenant des variants de protéine de surface CD45 discernables mais aussi une protéine de surface fonctionnelle à utiliser en thérapie, en particulier dans une thérapie cellulaire adoptive.
CA3240875A 2021-12-23 2022-12-23 Variants de proteine de surface cellulaire discernable de cd45 destines a etre utilises en therapie cellulaire Pending CA3240875A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP21217465.0 2021-12-23
EP21217465 2021-12-23
PCT/EP2022/087829 WO2023118608A1 (fr) 2021-12-23 2022-12-23 Variants de protéine de surface cellulaire discernable de cd45 destinés à être utilisés en thérapie cellulaire

Publications (1)

Publication Number Publication Date
CA3240875A1 true CA3240875A1 (fr) 2023-06-29

Family

ID=79171049

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3240875A Pending CA3240875A1 (fr) 2021-12-23 2022-12-23 Variants de proteine de surface cellulaire discernable de cd45 destines a etre utilises en therapie cellulaire

Country Status (10)

Country Link
EP (1) EP4452417A1 (fr)
JP (1) JP2025500288A (fr)
KR (1) KR20240119146A (fr)
CN (1) CN118541158A (fr)
AU (1) AU2022422572A1 (fr)
CA (1) CA3240875A1 (fr)
IL (1) IL313785A (fr)
MX (1) MX2024007316A (fr)
WO (1) WO2023118608A1 (fr)
ZA (1) ZA202405124B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3110837A1 (fr) 2018-08-28 2020-03-05 Vor Biopharma Inc. Cellules souches hematopoietiques genetiquement modifiees et utilisations associees
WO2026082736A1 (fr) * 2024-10-14 2026-04-23 Cimeio Therapeutics Ag Récepteur antigénique chimérique (car) ciblant la protéine tyrosine phosphatase de type récepteur c (cd45) et son utilisation dans des applications associées

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170226209A1 (en) 2014-08-01 2017-08-10 INSERM (Institut National de la Santé et de la Recherche Médicale) An anti-cd45rc antibody for use as drug
GB201601073D0 (en) 2016-01-20 2016-03-02 Ucb Biopharma Sprl Antibodies
CA3016901C (fr) 2016-03-07 2023-06-13 Actinium Pharmaceuticals, Inc. Compositions d'immunoglobulines anti-cd45 radio-marquees stabilisees
EP3448995A1 (fr) 2016-04-25 2019-03-06 Universität Basel Édition d'allèles et ses applications
CN109641051A (zh) 2016-06-17 2019-04-16 美真达治疗公司 用于耗尽细胞的组合物和方法
US20190365806A1 (en) 2016-11-02 2019-12-05 Universität Basel Immunologically discernible cell surface variants for use in cell therapy
KR102709603B1 (ko) 2017-02-28 2024-09-27 보르 바이오파마 인크. 계통 특이적 단백질의 억제를 위한 조성물 및 방법
CA3078963A1 (fr) 2017-10-25 2019-05-02 Actinium Pharmaceuticals, Inc. Procedes de conditionnement a base d'anti-cd45 et utilisations associees en combinaison avec des therapies a base de cellules genetiquement modifiees
EP3498293A1 (fr) 2017-12-15 2019-06-19 Institut National De La Sante Et De La Recherche Medicale (Inserm) Traitement de maladies monogéniques avec un anticorps anti-cd45rc
CN109991410B (zh) 2017-12-29 2022-07-05 上海白泽医学检验所有限公司 一种含抗cd45单抗的组合物及其使用方法
US20210269526A1 (en) 2018-07-16 2021-09-02 Fred Hutchinson Cancer Research Center Bispecific affinity reagent and related methods for pretargeted radioimmunotherapy against cd45+ cell
EP3626265A1 (fr) 2018-09-21 2020-03-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Anticorps anti-cd45rc anti-humains et leurs utilisations
AU2019374055B2 (en) * 2018-10-30 2026-06-11 Regeneron Pharmaceuticals, Inc. Methods for allogeneic hematopoietic stem cell transplantation
AU2019370367A1 (en) 2018-10-30 2021-06-17 Magenta Therapeutics, Inc. Anti-CD45 antibodies and conjugates thereof
EP3917313A4 (fr) 2019-02-01 2023-02-08 Actinium Pharmaceuticals, Inc. Molécules et leurs dérivés dirigés contre cd45
EP3927361A4 (fr) 2019-02-21 2022-11-30 Ramot at Tel-Aviv University Ltd. Traitement de maladies avec des peptides multimères

Also Published As

Publication number Publication date
KR20240119146A (ko) 2024-08-06
IL313785A (en) 2024-08-01
AU2022422572A1 (en) 2024-06-06
WO2023118608A1 (fr) 2023-06-29
MX2024007316A (es) 2024-06-26
CN118541158A (zh) 2024-08-23
EP4452417A1 (fr) 2024-10-30
ZA202405124B (en) 2025-10-29
JP2025500288A (ja) 2025-01-09

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