CA3247237A1 - Oligonucléotides pour moduler l’expression de tau - Google Patents

Oligonucléotides pour moduler l’expression de tau

Info

Publication number
CA3247237A1
CA3247237A1 CA3247237A CA3247237A CA3247237A1 CA 3247237 A1 CA3247237 A1 CA 3247237A1 CA 3247237 A CA3247237 A CA 3247237A CA 3247237 A CA3247237 A CA 3247237A CA 3247237 A1 CA3247237 A1 CA 3247237A1
Authority
CA
Canada
Prior art keywords
oligonucleotide
nucleosides
region
antisense oligonucleotide
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3247237A
Other languages
English (en)
Inventor
Peter Hagedorn
Anja Mølhart Høg
Richard E. Olson
Marianne L. JENSEN
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Priority to CA3247237A priority Critical patent/CA3247237A1/fr
Publication of CA3247237A1 publication Critical patent/CA3247237A1/fr
Pending legal-status Critical Current

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Abstract

"La présente invention concerne des oligonucléotides antisens qui sont capables de moduler l'expression de Tau dans une cellule cible. Les oligonucléotides s'hybrident à l'ARNm de MAPT. La présente invention concerne en outre des conjugués de l'oligonucléotide et des compositions pharmaceutiques et des méthodes pour le traitement de tauopathies, de la maladie d'Alzheimer, de la démence fronto-temporale (FTD), FTDP-17, de la paralysie supranucléaire progressive (PSP), de l'encéphalopathie traumatique chronique (CTE), de la dégénérescence ganglionnaire corticobasale (CBD), de l'épilepsie, du syndrome de Dravet, de la dépression, de troubles épileptiques et de troubles du mouvement."
CA3247237A 2018-07-03 2019-07-03 Oligonucléotides pour moduler l’expression de tau Pending CA3247237A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3247237A CA3247237A1 (fr) 2018-07-03 2019-07-03 Oligonucléotides pour moduler l’expression de tau

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62/693,851 2018-07-03
US62/726,005 2018-08-31
CA3247237A CA3247237A1 (fr) 2018-07-03 2019-07-03 Oligonucléotides pour moduler l’expression de tau

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA3103054A Division CA3103054C (fr) 2018-07-03 2019-07-03 Oligonucleotides pour moduler l'expression de tau

Publications (1)

Publication Number Publication Date
CA3247237A1 true CA3247237A1 (fr) 2025-06-06

Family

ID=97680139

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3247237A Pending CA3247237A1 (fr) 2018-07-03 2019-07-03 Oligonucléotides pour moduler l’expression de tau

Country Status (1)

Country Link
CA (1) CA3247237A1 (fr)

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