CH107537A - Process for the preparation of a water-soluble mixture of arsenic compounds. - Google Patents
Process for the preparation of a water-soluble mixture of arsenic compounds.Info
- Publication number
- CH107537A CH107537A CH107537DA CH107537A CH 107537 A CH107537 A CH 107537A CH 107537D A CH107537D A CH 107537DA CH 107537 A CH107537 A CH 107537A
- Authority
- CH
- Switzerland
- Prior art keywords
- water
- preparation
- arsenic compounds
- soluble mixture
- soluble
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims description 6
- 238000002360 preparation method Methods 0.000 title claims description 6
- 150000001495 arsenic compounds Chemical class 0.000 title claims description 4
- 229940093920 gynecological arsenic compound Drugs 0.000 title claims description 4
- 238000000034 method Methods 0.000 title claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- CTKINSOISVBQLD-UHFFFAOYSA-N Glycidol Chemical compound OCC1CO1 CTKINSOISVBQLD-UHFFFAOYSA-N 0.000 claims description 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical class Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 229910000413 arsenic oxide Inorganic materials 0.000 description 1
- 229960002594 arsenic trioxide Drugs 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000012458 free base Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Description
Verfahren zur Darstellung eines in Wasser löslichen Gemisches von Arsenverbindungen. Es wurde gefunden, @dass man zu einem Gemisch von ausserordentlich .leicht löslichen Arsenverbindungen von vorzüglichen thera peutischen Eigenschaften gelangt, wenn. man auf 4-Oxy-3-aminobenzol@arsenoxyd Epihy- drznalkohol einwirken lässt. Die im Gemisch enthaltenen neuen Produkte lassen sich in Arsenobenzole überführen. Das erhaltene Prä parat ist in Wasser klar löslich und hat eine grauweisse Farbe.
Beispiel: 19,9 gr 4-Oxy-3-aminobenzolarsenoxyd werden in 50 gr Methylalkohol eingetragen und dann etwa 12 gr Glycid zugegeben. Man lässt bis zur Beendigung der Reaktion stehen und kann gegebenenfalls durch Erwärmen auf<B>60'</B> die Reaktion beschleunigen. Die Re aktion ist beendet, wenn eine gezogene Probe in Wasser klar löslich ist. Man filtriert und fällt die in dem Filtrat gelöste Substanz mit Äther aus. Die ausgefallene Substanz wird abgesaugt und getrocknet.
Das erhaltene Prä parat ist in Wasser klar löslich, von grauer bis weisser Farbe. Anstatt der freien Base kann auch das salzsaure Salz genommen werden.
Process for the preparation of a water-soluble mixture of arsenic compounds. It has been found that a mixture of extraordinarily easily soluble arsenic compounds with excellent therapeutic properties can be obtained if. 4-oxy-3-aminobenzene @ arsenic oxide epihydric alcohol is allowed to act. The new products contained in the mixture can be converted into arsenobenzenes. The preparation obtained is clearly soluble in water and has a gray-white color.
Example: 19.9 g of 4-oxy-3-aminobenzolarenoxide are added to 50 g of methyl alcohol and then about 12 g of glycide are added. The mixture is left to stand until the reaction has ended and the reaction can optionally be accelerated by heating to <B> 60 '</B>. The reaction is over when a drawn sample is clearly soluble in water. It is filtered and the substance dissolved in the filtrate is precipitated with ether. The precipitated substance is filtered off with suction and dried.
The preparation obtained is clearly soluble in water, gray to white in color. The hydrochloric acid salt can also be used instead of the free base.
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE107537X | 1923-07-06 | ||
| CH107298T | 1923-12-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH107537A true CH107537A (en) | 1924-11-01 |
Family
ID=25707154
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH107537D CH107537A (en) | 1923-07-06 | 1923-12-24 | Process for the preparation of a water-soluble mixture of arsenic compounds. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH107537A (en) |
-
1923
- 1923-12-24 CH CH107537D patent/CH107537A/en unknown
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