CH140913A - Process for the preparation of a condensation product of the benzodiazine series. - Google Patents
Process for the preparation of a condensation product of the benzodiazine series.Info
- Publication number
- CH140913A CH140913A CH140913DA CH140913A CH 140913 A CH140913 A CH 140913A CH 140913D A CH140913D A CH 140913DA CH 140913 A CH140913 A CH 140913A
- Authority
- CH
- Switzerland
- Prior art keywords
- benzodiazine
- series
- preparation
- condensation product
- product
- Prior art date
Links
- WCZVZNOTHYJIEI-UHFFFAOYSA-N cinnoline Chemical class N1=NC=CC2=CC=CC=C21 WCZVZNOTHYJIEI-UHFFFAOYSA-N 0.000 title claims description 4
- 239000007859 condensation product Substances 0.000 title claims description 4
- 238000000034 method Methods 0.000 title claims description 4
- 238000002360 preparation method Methods 0.000 title claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 239000000975 dye Substances 0.000 claims description 2
- 239000005457 ice water Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 238000002844 melting Methods 0.000 claims description 2
- 230000008018 melting Effects 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims description 2
- 239000000047 product Substances 0.000 claims description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 2
- QPFMBZIOSGYJDE-UHFFFAOYSA-N 1,1,2,2-tetrachloroethane Chemical compound ClC(Cl)C(Cl)Cl QPFMBZIOSGYJDE-UHFFFAOYSA-N 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- TUQSVSYUEBNNKQ-UHFFFAOYSA-N 2,4-dichloroquinazoline Chemical compound C1=CC=CC2=NC(Cl)=NC(Cl)=C21 TUQSVSYUEBNNKQ-UHFFFAOYSA-N 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Description
Verfahren zur Darstellung eines Kondensationsproduktes der Benzodiazinreihe. Gegenstand vorliegender Erfindung ist ein Verfahren zur Darstellung eines Konden sationsproduktes der Benzodiazinreihe von der Formel:
EMI0001.0003
dadurch gekennzeichnet, dass man 2 Mol 1- Oxynaphtalin mit 1 Mol 2.4-Dihalogenchi- nazolin kondensiert.
Beispiel 145 Gewichtsteile 1-Ogynaphtalin werden in 1000 Teilen Tetrachloräthan gelöst, da- zu gibt man 100 Gewichtsteile 2.4-Dichlor- chinazolin und in Portionen 160 Gewichts teile gepulvertes, wasserfreies Aluminium chlorid. Man erhitzt eine Stunde auf 90 bis <B>1000</B> und arbeitet wie üblich auf. Das er haltene, gelbliche Pulver ist das 2.4-Di(4'- ogynaphtyl)-chinazolin.
Es lässt sich aus Alkohol umkristallisie- ren. Bei 240-2600 verkohlt es ohne zu schmelzen. In konzentrierter Schwefelsäure löst es sich mit intensiver violetter Farbe, durch Eingiessen in Eiswasser erhält man das Produkt unverändert zurück. Es soll als Zwischenprodukt für die Herstellung von Farbstoffen und Arzneimitteln Verwendung finden.
Process for the preparation of a condensation product of the benzodiazine series. The present invention is a process for the preparation of a condensation product of the benzodiazine series of the formula:
EMI0001.0003
characterized in that 2 moles of 1-oxynaphthalene are condensed with 1 mole of 2,4-dihaloquinazoline.
Example 145 parts by weight of 1-ogynaphthalene are dissolved in 1000 parts of tetrachloroethane, 100 parts by weight of 2,4-dichloroquinazoline and 160 parts by weight of powdered, anhydrous aluminum chloride are added in portions. The mixture is heated to between 90 and 1000 for one hour and worked up as usual. The yellowish powder he obtained is 2,4-di (4'- ogynaphtyl) -quinazoline.
It can be recrystallized from alcohol. At 240-2600 it carbonizes without melting. It dissolves in concentrated sulfuric acid with an intense violet color; the product is returned unchanged by pouring it into ice water. It is intended to be used as an intermediate in the manufacture of dyes and drugs.
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE140913X | 1927-03-18 | ||
| CH138869T | 1928-03-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH140913A true CH140913A (en) | 1930-06-30 |
Family
ID=25713251
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH140913D CH140913A (en) | 1927-03-18 | 1928-03-14 | Process for the preparation of a condensation product of the benzodiazine series. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH140913A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015127569A1 (en) | 2014-02-25 | 2015-09-03 | Polarmond Ag | Sleeping system |
-
1928
- 1928-03-14 CH CH140913D patent/CH140913A/en unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015127569A1 (en) | 2014-02-25 | 2015-09-03 | Polarmond Ag | Sleeping system |
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