CH170699A - Process for the preparation of the sodium salt of muscle adenyl pyrophosphoric acid. - Google Patents
Process for the preparation of the sodium salt of muscle adenyl pyrophosphoric acid.Info
- Publication number
- CH170699A CH170699A CH170699DA CH170699A CH 170699 A CH170699 A CH 170699A CH 170699D A CH170699D A CH 170699DA CH 170699 A CH170699 A CH 170699A
- Authority
- CH
- Switzerland
- Prior art keywords
- adenyl
- muscle
- pyrophosphoric acid
- sodium salt
- preparation
- Prior art date
Links
- ZKHQWZAMYRWXGA-KQYNXXCUSA-N Adenosine triphosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-N 0.000 title claims description 9
- 210000003205 muscle Anatomy 0.000 title claims description 8
- 159000000000 sodium salts Chemical class 0.000 title claims description 7
- 238000000034 method Methods 0.000 title claims description 4
- 238000002360 preparation method Methods 0.000 title description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 150000001875 compounds Chemical class 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 229940126601 medicinal product Drugs 0.000 claims description 2
- XPPKVPWEQAFLFU-UHFFFAOYSA-N diphosphoric acid Chemical compound OP(O)(=O)OP(O)(O)=O XPPKVPWEQAFLFU-UHFFFAOYSA-N 0.000 claims 1
- 229940005657 pyrophosphoric acid Drugs 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
- 239000000243 solution Substances 0.000 description 3
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 2
- AYJRCSIUFZENHW-UHFFFAOYSA-L barium carbonate Chemical compound [Ba+2].[O-]C([O-])=O AYJRCSIUFZENHW-UHFFFAOYSA-L 0.000 description 2
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 229910000037 hydrogen sulfide Inorganic materials 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000003929 acidic solution Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 159000000009 barium salts Chemical class 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 150000002611 lead compounds Chemical class 0.000 description 1
- 229940056932 lead sulfide Drugs 0.000 description 1
- 229910052981 lead sulfide Inorganic materials 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
Landscapes
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Verfahren zur Herstellung des Natriumsalzes der Muskeladenylpyropliosphorsäure. In dem Hauptpatent ist ein Verfahren zur Herstellung des Natriumsalzes der Adenyl- pyrophosphorsäure beschrieben, wobei ein in Wasser schwer lösliches Salz dieser Säure mit einem Natriumsalz umgesetzt wird.
Gegenstand der vorliegenden Erfindung ist ein Verfahren zur Herstellung des Natrium salzes der Muskeladenylpyrophosphorsäure, das dadurch gekennzeichnet ist, dass man Muskeladenylpyrophosphorsäure mit Natron lauge umsetzt.
Die neue Verbindung ist weiss und in Wasser leicht löslich; sie soll als Arznei mittel Verwendung finden.
<I>Beispiele:</I> 1. 5 gr Bariumsalz der Muskeladenyl- pyrophosphorsäure werden in einer gekühlten Kugelmühle mit Wasser angerieben und mit etwas mehr als der berechneten Menge ver dünnter Schwefelsäure versetzt. Man lässt unter dauernder Kühlung so lange kugeln, bis die Umsetzung quantitativ ist, trennt dann das Bariumsulfat ab, entfernt den Über schuss der Schwefelsäure vorsichtig mit Bariumkarbonat und bringt nach Neutrali sieren mit Natronlauge die erhaltene neutral oder schwach sauer reagierende Lösung vor sichtig im Vakuum zur Trockne.
2. Die Bleiverbindung der Muskeladenyl- pyrophosphorsäure, wie sie zum Beispiel nach Lohman, Biochemische Zeitschrift 1931, Bd. 233, S. 466, bei der letzten Reinigung erhalten wird, wird in Wasser suspendiert, mit Schwefelwasserstoff zersetzt und vom Bleisulfid abgetrennt. Das Filtrat wird nach Entfernen des Schwefelwasserstoffes mit Natronlauge auf schwach saure Reaktion ge bracht, auf ein geringes Volumen eingeengt und durch Fällen mit Alkohol das Natrium salz der Muskeladenylpy rophosphorsäure er halten.
Process for the preparation of the sodium salt of muscle adenyl pyrophosphoric acid. The main patent describes a process for the preparation of the sodium salt of adenyl pyrophosphoric acid, a salt of this acid which is sparingly soluble in water being reacted with a sodium salt.
The present invention relates to a process for preparing the sodium salt of muscle adenyl pyrophosphoric acid, which is characterized in that muscle adenyl pyrophosphoric acid is reacted with sodium hydroxide solution.
The new compound is white and easily soluble in water; it is said to be used as a medicinal product.
<I> Examples: </I> 1. 5 grams of barium salt of muscle adenyl pyrophosphoric acid are rubbed with water in a cooled ball mill and mixed with a little more than the calculated amount of diluted sulfuric acid. The balls are left with constant cooling until the reaction is quantitative, then the barium sulfate is separated off, the excess sulfuric acid is carefully removed with barium carbonate and, after neutralization with sodium hydroxide solution, the resulting neutral or weakly acidic solution is carefully placed in a vacuum Dry.
2. The lead compound of muscle adenyl pyrophosphoric acid, as obtained, for example, according to Lohman, Biochemische Zeitschrift 1931, Vol. 233, p. 466, during the last purification, is suspended in water, decomposed with hydrogen sulfide and separated from the lead sulfide. After removing the hydrogen sulfide with sodium hydroxide solution, the filtrate is brought to a weakly acidic reaction, concentrated to a small volume and the sodium salt of muscle adenylpyrophosphoric acid is kept by precipitation with alcohol.
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE170699X | 1932-02-27 | ||
| CH166965T | 1933-02-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH170699A true CH170699A (en) | 1934-07-15 |
Family
ID=25718371
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH170699D CH170699A (en) | 1932-02-27 | 1933-02-22 | Process for the preparation of the sodium salt of muscle adenyl pyrophosphoric acid. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH170699A (en) |
-
1933
- 1933-02-22 CH CH170699D patent/CH170699A/en unknown
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