CH177155A - Process for the preparation of a cholesterol ester. - Google Patents

Process for the preparation of a cholesterol ester.

Info

Publication number
CH177155A
CH177155A CH177155DA CH177155A CH 177155 A CH177155 A CH 177155A CH 177155D A CH177155D A CH 177155DA CH 177155 A CH177155 A CH 177155A
Authority
CH
Switzerland
Prior art keywords
cholesterol
preparation
cholesterol ester
heated
process according
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellsc Farbenindustrie
Original Assignee
Ig Farbenindustrie Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ig Farbenindustrie Ag filed Critical Ig Farbenindustrie Ag
Publication of CH177155A publication Critical patent/CH177155A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Description

  

  Verfahren zur Darstellung eines     Cholesterinesters.       In dem Patent<B>170615</B> ist die Darstellung  eines therapeutisch wertvollen     Cholesterin-          esters    durch     Veresterung    von     Chaulmoogra-          säure    mit Cholesterin beschrieben.  



  Gegenstand der vorliegenden Erfindung ist  ein     Verfahren    zur Darstellung eines     Cholesterin-          esters,    das dadurch gekennzeichnet ist, dass  man Cholesterin zur Umsetzung bringt mit  einer Verbindung der Formel  
EMI0001.0010     
    worin X einen bei der Umsetzung mit Chol  esterin sich abspaltenden Rest bedeutet.  



  Das so erhaltene neue Produkt bildet  weisse Blättchen vom Schmelzpunkt     63-65      C.  Es soll als Arzneimittel Verwendung finden.  <I>Beispiel:</I>  10     gr    Cholesterin und 30     gr        Hydnocarp-          säure    werden im Ölbad unter Durchleiten von  Kohlensäure 5 Stunden auf 250-270   er  hitzt. Nach teilweisem Erkalten wird in 250     cm3            abs.    Alkohol gegossen, woraus nach einiger  Zeit der     Hydnocarpsäurecholesterylester    in  weissen Blättchen ausfällt.

   Durch     Umkristalli-          sieren    aus     Alkohol-Essigester    wird die neue  Verbindung in Blättchen vom Schmelzpunkt  63-65   erhalten. Die Ausbeute beträgt 14     gr.     An Stelle der     Hy        dnocarpsäure    kann auch die  entsprechende Menge     Hydnocarpsäurechlorid     zur Verwendung gelangen.



  Process for the preparation of a cholesterol ester. The patent <B> 170615 </B> describes the preparation of a therapeutically valuable cholesterol ester by esterifying chaulmograic acid with cholesterol.



  The present invention relates to a process for the preparation of a cholesterol ester, which is characterized in that cholesterol is reacted with a compound of the formula
EMI0001.0010
    where X is a radical which is split off on reaction with cholesterol.



  The new product obtained in this way forms white flakes with a melting point of 63-65 C. It is said to be used as a medicinal product. <I> Example: </I> 10 grams of cholesterol and 30 grams of hydnocarpic acid are heated to 250-270 for 5 hours in an oil bath while passing through carbonic acid. After partial cooling, abs. Poured alcohol, from which after a while the hydnocarpic acid cholesteryl ester precipitates in white flakes.

   Recrystallization from alcohol / ethyl acetate gives the new compound in flakes with a melting point of 63-65. The yield is 14 g. Instead of hy dnocarpic acid, the corresponding amount of hydnocarpic acid chloride can also be used.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung eines Chol- esterinesters, dadurch gekennzeichnet, dass man Cholesterin zur Umsetzung bringt mit einer Verbindung der Formel EMI0001.0028 worin g einen bei der Umsetzung mit Chol esterin sich abspaltenden Rest bedeutet. Das so erhaltene neue Produkt bildet weisse Blättchen vom Schmelzpunkt 63-65 C. Es soll als Arzneimittel Verwendung finden. UNTERS NSPRü CHE 1. Verfahren nach Patentanspruch, dadurch gekennzeichnet, dass man Hydnocarpsäure mit Cholesterin erhitzt. 2. PATENT CLAIM: Process for the preparation of a cholesterol ester, characterized in that cholesterol is reacted with a compound of the formula EMI0001.0028 in which g is a radical which is split off in the reaction with cholesterol. The new product obtained in this way forms white flakes with a melting point of 63-65 C. It is said to be used as a medicinal product. UNTERS NSPRü CHE 1. Process according to claim, characterized in that hydnocarpic acid is heated with cholesterol. 2. Verfahren nach Patentanspruch, dadurch gekennzeichnet, dass man Hydnocarpsäure- chlorid mit Cholesterin erhitzt. Process according to patent claim, characterized in that hydnocarpic acid chloride is heated with cholesterol.
CH177155D 1933-06-29 1933-06-29 Process for the preparation of a cholesterol ester. CH177155A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH170615T 1933-06-29
CH177155T 1933-06-29

Publications (1)

Publication Number Publication Date
CH177155A true CH177155A (en) 1935-05-15

Family

ID=25718943

Family Applications (1)

Application Number Title Priority Date Filing Date
CH177155D CH177155A (en) 1933-06-29 1933-06-29 Process for the preparation of a cholesterol ester.

Country Status (1)

Country Link
CH (1) CH177155A (en)

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