CH179973A - Process for the preparation of a mixture of isomeric octahydrofollicle hormones of the formula C18H30O2. - Google Patents
Process for the preparation of a mixture of isomeric octahydrofollicle hormones of the formula C18H30O2.Info
- Publication number
- CH179973A CH179973A CH179973DA CH179973A CH 179973 A CH179973 A CH 179973A CH 179973D A CH179973D A CH 179973DA CH 179973 A CH179973 A CH 179973A
- Authority
- CH
- Switzerland
- Prior art keywords
- formula
- octahydrofollicle
- isomeric
- hormones
- mixture
- Prior art date
Links
- 229940088597 hormone Drugs 0.000 title claims description 7
- 239000005556 hormone Substances 0.000 title claims description 7
- 238000000034 method Methods 0.000 title claims description 4
- 239000000203 mixture Substances 0.000 title claims description 4
- 125000005481 linolenic acid group Chemical group 0.000 title claims 2
- 239000003054 catalyst Substances 0.000 claims description 4
- 238000002844 melting Methods 0.000 claims description 3
- 230000008018 melting Effects 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 238000005984 hydrogenation reaction Methods 0.000 claims description 2
- 125000001997 phenyl group Chemical class [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 2
- 239000011347 resin Substances 0.000 claims description 2
- 229920005989 resin Polymers 0.000 claims description 2
- 230000001766 physiological effect Effects 0.000 claims 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 229960000583 acetic acid Drugs 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000012362 glacial acetic acid Substances 0.000 description 1
- 239000000745 gonadal hormone Substances 0.000 description 1
- 229940126601 medicinal product Drugs 0.000 description 1
- KIDPOJWGQRZHFM-UHFFFAOYSA-N platinum;hydrate Chemical compound O.[Pt] KIDPOJWGQRZHFM-UHFFFAOYSA-N 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
Description
Verfahren zur Darstellung eines Gemisches isomerer Octahydrofollikelhormone der Formel CisHso02. Gegenstand vorliegenden Patentes ist ein Verfahren zur Herstellung eines Gemi sches isomerer Octahydrofollikelhormone der Formel C1.H3,02, das dadurch gekennzeich net ist, dass man das Reduktionsprodukt der Formel C"H"02 vom Schmelzpunkt 1,68 bis <B>170'</B> C des Follikelhormons in Anwesenheit eines Katalysators, der die Hydrierung des Benzolkernes begünstigt, mit einem hydrie renden Mittel bis zur Bildung des Produktes C"H3@0,
behandelt.
Das neue Produkt soll als Arzneimittel zur 'Behebung von Ausfallserscheinungen, wie sie am männlichen Organismus bei Man gel an männlichem Keimdrüsenhormon beob achtet werden, Verwendung finden. <I>Beispiel:</I> 1 g Dihydrofollikelhormon 618H2402 vom Schmelzpunkt 16$ bis<B>170'</B> werden in 150 cm' reinem Eisessig gelöst und die Lö sung nach Zugabe vom 200 mg Platinogyd- katalysator nach Adams-Shriner bei Zim mertemperatur in einer Wasserstoffatmo- sphäre geschüttelt.
Nach beendeter Wasser stoffaufnahme wird die vom Katalysator be freite Reaktionslösung im Vaccum zur Trockne abgedampft. Es hinterbleibt als Rückstand ein helles konsistentes Harz mit einem physiologischen Wirkungswert von zirka 8 mg/KE.
Process for the preparation of a mixture of isomeric octahydrofollicle hormones of the formula CisHso02. The present patent relates to a process for the preparation of a mixture of isomeric octahydrofollicle hormones of the formula C1.H3,02, which is characterized in that the reduction product of the formula C "H" 02 has a melting point of 1.68 to 170 ' / B> C of the follicle hormone in the presence of a catalyst that favors the hydrogenation of the benzene nucleus, with a hydrogenating agent until the product C "H3 @ 0 is formed,
treated.
The new product is intended to be used as a medicinal product for 'remedying failure symptoms such as those observed in the male organism when there is a lack of male gonadal hormone. <I> Example: </I> 1 g of dihydrofollicle hormone 618H2402 with a melting point of 16 $ to <B> 170 '</B> is dissolved in 150 cm' of pure glacial acetic acid and the solution after adding 200 mg of platinum hydrate catalyst according to Adams- Shriner shaken in a hydrogen atmosphere at room temperature.
After the uptake of hydrogen has ended, the reaction solution freed from the catalyst is evaporated to dryness in a vacuum. A pale, consistent resin with a physiological action value of approximately 8 mg / CU remains as the residue.
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE179973X | 1932-10-27 | ||
| CH173197T | 1933-10-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH179973A true CH179973A (en) | 1935-09-30 |
Family
ID=25719329
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH179973D CH179973A (en) | 1932-10-27 | 1933-10-10 | Process for the preparation of a mixture of isomeric octahydrofollicle hormones of the formula C18H30O2. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH179973A (en) |
-
1933
- 1933-10-10 CH CH179973D patent/CH179973A/en unknown
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