CH200914A - Process for the production of an imidazole. - Google Patents

Process for the production of an imidazole.

Info

Publication number
CH200914A
CH200914A CH200914DA CH200914A CH 200914 A CH200914 A CH 200914A CH 200914D A CH200914D A CH 200914DA CH 200914 A CH200914 A CH 200914A
Authority
CH
Switzerland
Prior art keywords
imidazole
production
heptadecylimidazole
heptadecylimidazoline
colorless
Prior art date
Application number
Other languages
German (de)
Inventor
Gesellschaft Fuer Chemis Basel
Original Assignee
Chem Ind Basel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chem Ind Basel filed Critical Chem Ind Basel
Publication of CH200914A publication Critical patent/CH200914A/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

  

  Verfahren zur Herstellung eines     Imidazols.       Es wurde gefunden, dass man ein     Imid-          azol,    das     2-Heptadecylimidazol,    in sehr guter  Ausbeute erhält, wenn man das     2.-Heptade-          cylimidazolin    mit     Dehydrierungskatalysatoren     in der Wärme behandelt. Das     2-Heptadecyl-          imidazol,    eine farblose, feste Masse vom  Schmelzpunkt 83,5 bis 84  , kann als Aus  gangsstoff zur Herstellung von Medikamenten  verwendet werden.  



  <I>Beispiel:</I>  150 Teile     2-Heptadecylimidazolin    werden  mit 6 Teilen frisch reduziertem, fein ver  teiltem Nickel unter Rühren auf 180   bis  240   erhitzt. Schon bei 190   tritt eine kräf  tige Wasserstoffentwicklung ein. Nach etwa  zweistündiger Reaktionsdauer wird das Re  aktionsprodukt direkt bei 15 mm Druck vom  Katalysator     abdestilliert.    Man erhält in guter    Ausbeute ein farbloses, festes Destillat. Nach  zweimaligem     Umkristallisieren    des Produk  tes aus Methylalkohol besitzt das erhaltene       2-Heptadecylimidazol    einen Schmelzpunkt  von     83,5    bis 84  .



  Process for the production of an imidazole. It has been found that an imidazole, 2-heptadecylimidazole, is obtained in very good yield if the 2.-heptadecylimidazoline is treated with hot dehydrogenation catalysts. The 2-heptadecyl imidazole, a colorless, solid mass with a melting point of 83.5 to 84, can be used as a starting material for the manufacture of drugs.



  <I> Example: </I> 150 parts of 2-heptadecylimidazoline are heated to 180 to 240 with 6 parts of freshly reduced, finely divided nickel while stirring. A powerful evolution of hydrogen occurs as early as 190. After about two hours of reaction time, the reaction product is distilled off directly from the catalyst at 15 mm pressure. A colorless, solid distillate is obtained in good yield. After the product has been recrystallized twice from methyl alcohol, the 2-heptadecylimidazole obtained has a melting point of 83.5 to 84.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung des 2-Hepta- decylimidazols, dadurch gekennzeichnet, dass man das 2-Heptadecylimidazolin mit Dehy- drierungskatalysatoren in der Wärme be handelt. Das 2-Heptadecylimidazol, eine farblose, feste Masse vom Schmelzpunkt 83,5 bis 84 , kann als Ausgangsstoff zur Herstellung von Medikamenten verwendet werden. PATENT CLAIM: Process for the production of 2-heptadecylimidazole, characterized in that the 2-heptadecylimidazoline is treated with dehydration catalysts in the heat. The 2-heptadecylimidazole, a colorless, solid mass with a melting point of 83.5 to 84, can be used as a starting material for the manufacture of medicaments.
CH200914D 1936-06-20 1936-06-20 Process for the production of an imidazole. CH200914A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH193338T 1936-06-20
CH200914T 1936-06-20

Publications (1)

Publication Number Publication Date
CH200914A true CH200914A (en) 1938-10-31

Family

ID=25722468

Family Applications (1)

Application Number Title Priority Date Filing Date
CH200914D CH200914A (en) 1936-06-20 1936-06-20 Process for the production of an imidazole.

Country Status (1)

Country Link
CH (1) CH200914A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116253684A (en) * 2023-02-17 2023-06-13 天津工业大学 A kind of 2-heptadecyl imidazole and its synthetic method

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116253684A (en) * 2023-02-17 2023-06-13 天津工业大学 A kind of 2-heptadecyl imidazole and its synthetic method

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