CH201766A - Process for preparing a bactericidal substance. - Google Patents
Process for preparing a bactericidal substance.Info
- Publication number
- CH201766A CH201766A CH201766DA CH201766A CH 201766 A CH201766 A CH 201766A CH 201766D A CH201766D A CH 201766DA CH 201766 A CH201766 A CH 201766A
- Authority
- CH
- Switzerland
- Prior art keywords
- preparing
- mol
- bactericidal substance
- substance
- acid
- Prior art date
Links
- 239000003899 bactericide agent Substances 0.000 title claims description 4
- 238000004519 manufacturing process Methods 0.000 title claims description 3
- VKYKSIONXSXAKP-UHFFFAOYSA-N hexamethylenetetramine Chemical compound C1N(C2)CN3CN1CN2C3 VKYKSIONXSXAKP-UHFFFAOYSA-N 0.000 claims description 6
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 claims description 3
- RGHNJXZEOKUKBD-SQOUGZDYSA-N Gluconic acid Natural products OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 claims description 3
- 235000012208 gluconic acid Nutrition 0.000 claims description 3
- 239000000174 gluconic acid Substances 0.000 claims description 3
- 235000010299 hexamethylene tetramine Nutrition 0.000 claims description 3
- 239000004312 hexamethylene tetramine Substances 0.000 claims description 3
- 239000002904 solvent Substances 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 2
- 238000006243 chemical reaction Methods 0.000 claims description 2
- 239000013078 crystal Substances 0.000 claims description 2
- 238000002844 melting Methods 0.000 claims description 2
- 230000008018 melting Effects 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 239000007859 condensation product Substances 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 150000002402 hexoses Chemical class 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
Landscapes
- Polysaccharides And Polysaccharide Derivatives (AREA)
Description
Procédé de préparation d'une substance bactéricide. La présente invention a pour but la pré paration d'une substance bactéricide qui est particulièrement d'une grande valeur pour la conservation du sang humain ou animal des tiné à être utilisé pour des transfusions san guines.
Il a été trouvé que les produits de con densation des acides obtenus par l'oxydation des hexoses ou de polysaccharides, avec des amines et des acides cycliques ont un très grand pouvoir désinfectant et conservant, ce qui avec d'autres propriétés propices, les rend spécialement utilisables pour les buts sus-in- diqués.
Le procédé suivant l'invention est carac térisé par le fait qu'on fait réagir ensemble 1 mol d'acide gluconique, 2 mol d'hexaméthy- lènetétramine et 1 mol d'acide 1,2,2-trimé- thyle-cis-cyclopentane-dicarbonique (1,3).
La nouvelle substance forme des cristaux dont le point de fusion est entre 160 et 165 . La réaction est effectuée de préférence en présence d'un solvant, comme par exemple le chloroforme, etc. Exemple: 200 g d'acide 1,2,2-triméthyle-cis-cyclo- pentane-dicarbonique (1,3), 280 g d'hexamé- thylénetétramine et 196 g d'acide gluconique sont chauffés ensemble en présence de mé- thyléthylecétone comme solvant.
La substance finale ayant un caractère acide peut facilement être isolée sous forme d'un sel alcalin ou alcalino-terreux.
Process for preparing a bactericidal substance. The object of the present invention is the preparation of a bactericidal substance which is particularly of great value for the preservation of human or animal blood for use in blood transfusions.
It has been found that the acid condensation products obtained by the oxidation of hexoses or polysaccharides, with amines and cyclic acids have a very high disinfecting and preserving power, which together with other favorable properties, makes them specially usable for the above purposes.
The process according to the invention is characterized by the fact that 1 mol of gluconic acid, 2 mol of hexamethylenetetramine and 1 mol of 1,2,2-trimethyl-cis- acid are reacted together. cyclopentane-dicarbonic (1,3).
The new substance forms crystals with a melting point between 160 and 165. The reaction is preferably carried out in the presence of a solvent, such as for example chloroform, etc. Example: 200 g of 1,2,2-trimethyl-cis-cyclopentan-dicarbonic acid (1,3), 280 g of hexamethylenetetramine and 196 g of gluconic acid are heated together in the presence of me- thylethyl ketone as a solvent.
The final substance having an acidic character can easily be isolated as an alkali or alkaline earth salt.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH201766T | 1937-09-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH201766A true CH201766A (en) | 1938-12-15 |
Family
ID=4442933
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH201766D CH201766A (en) | 1937-09-30 | 1937-09-30 | Process for preparing a bactericidal substance. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH201766A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010510199A (en) * | 2006-11-17 | 2010-04-02 | ゴンベール ベルナール ルシエン | Antimicrobial terpene composition |
-
1937
- 1937-09-30 CH CH201766D patent/CH201766A/en unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010510199A (en) * | 2006-11-17 | 2010-04-02 | ゴンベール ベルナール ルシエン | Antimicrobial terpene composition |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB404938A (en) | Manufacture of chlorhydrins and ethers thereof | |
| CH201766A (en) | Process for preparing a bactericidal substance. | |
| CH631151A5 (en) | PROCESS FOR THE PREPARATION OF HEMACETAL-ESTERS OF GLYOXYLIC ACID. | |
| Bachman | Dehalogenation of aliphatic bromo acids. The bromo and dibromo olefins | |
| CH203886A (en) | Process for preparing a bactericidal substance. | |
| GB572401A (en) | Improved polymeric silicone and methods of making it | |
| US2370540A (en) | Chlobomethyii ethers of nttko | |
| Niederl et al. | The synthesis of phenolic long chain fatty acids | |
| Felton | Some reactions of ethyl cyanoacetate | |
| US1701473A (en) | Process of producing diacetone alcohol | |
| GB472545A (en) | Improvements relating to the preparation, purification or separation of oxo-compounds | |
| US767291A (en) | Process of making odoriferous compound. | |
| US1840134A (en) | Production of organic products from meat pickle brine | |
| Butz | The Dehydration of 1, 5-Hexadiene-3-ol to 1, 3, 5-Hexatriene and 1, 3-Cyclohexadiene1 | |
| JPS58203930A (en) | Alkyl 4-(2-methylene-6,6-dimethylcyclohexyl)-2-methyl-2,3-epoxybutyrates | |
| CH200185A (en) | Process for preparing the alpha-phenyl-n-valerate of diethylaminoethanol. | |
| GB491265A (en) | Improvements in and relating to the manufacture of new compounds of therapeutic value | |
| Goulding et al. | CCXLIV.—Volatile oil from the leaves of Barosma venusta | |
| CH115313A (en) | Process for the preparation of borneol by betapinene. | |
| US1967440A (en) | Process of making thymol | |
| SU89446A1 (en) | The method of obtaining beta-Rodan-beta'-chlorodiethyl ether and the use of this ether for the destruction of harmful insects and their eggs | |
| Wood et al. | 1-Nitromethylcyclohexanol and Homologs | |
| US617552A (en) | Philippe barbier | |
| Mattar et al. | CCCXXI.—4-Alkyl derivatives of 1-phenyl cyclo hexane-3: 5-dione | |
| GB591273A (en) | Improvements in the manufacture of disinfectants and chlorinated tar acids for use therefor |