CH209821A - Process for the preparation of a thiazolium compound. - Google Patents

Process for the preparation of a thiazolium compound.

Info

Publication number
CH209821A
CH209821A CH209821DA CH209821A CH 209821 A CH209821 A CH 209821A CH 209821D A CH209821D A CH 209821DA CH 209821 A CH209821 A CH 209821A
Authority
CH
Switzerland
Prior art keywords
preparation
thiazolium
methyl
compound
hydroiodide
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellsc Farbenindustrie
Original Assignee
Ig Farbenindustrie Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ig Farbenindustrie Ag filed Critical Ig Farbenindustrie Ag
Publication of CH209821A publication Critical patent/CH209821A/en

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Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Description

  

  Verfahren zur Darstellung einer     Thiazoliumverbindung.       Das Hauptpatent     betrifft    die Herstellung  einer durch     antineuritische    Wirkung ausge  zeichneten     Pyrimidylalkylthiazoliumverbin-          dung.     



  Gegenstand des vorliegenden Patentes ist  ein Verfahren zur Herstellung einer     Thiazo-          liumverbindung,    dadurch gekennzeichnet, dass  man     2-Methyl-4-amino-5-jodmethyl-pyrimidin-          hydrojodid    auf     4-Äthyl-5-oxyäthyl-thiazol    ein  wirken lässt. Das so erhältliche     Hydrojodid     des N - (2' -     Methyl    - 4'-     aminopyrimidyl    -     [5']        -          methyl)-4-äthyl-5-oxyäthyl-thiazoliumjodids     bildet Kristalle vom F. 212  .

   Die Verbindung  zeigt eine starke     antineuritische    Wirksamkeit  und soll therapeutische Anwendung finden.  <I>Beispiel:</I>  5 g     2-Methyl-4-amino-5-jodmethyl-pyrimi-          din-hydrojodid    werden mit 5 g     4-Äthyl        -5-          oxyäthylthiazol        1/2    Stunde auf     120-130'    er  hitzt. Die Schmelze wird mit Äther verrührt    und das zurückbleibende Pulver aus Alkohol  und etwas Wasser umkristallisiert.

   Man er  hält das     Hydrojodid    des N-(2'-Methyl-4'       aminopyrimidyl-[5']-methyl)-4-äthyl-5-oxy-          äthyl-thiazoliumjodids    in Kristallen vom  F. 212  . Die Verbindung zeigt eine starke       antineuritische        Wirksamkeit.  



  Process for the preparation of a thiazolium compound. The main patent relates to the production of a pyrimidylalkylthiazolium compound which is distinguished by its antineuritic effect.



  The subject of the present patent is a process for the preparation of a thiazolium compound, characterized in that 2-methyl-4-amino-5-iodomethyl-pyrimidine-hydroiodide is allowed to act on 4-ethyl-5-oxyethyl-thiazole. The thus obtainable hydroiodide of N - (2 '- methyl - 4'-aminopyrimidyl - [5'] - methyl) -4-ethyl-5-oxyethyl-thiazolium iodide forms crystals of F. 212.

   The compound shows strong antineuritic activity and is said to find therapeutic use. <I> Example: </I> 5 g of 2-methyl-4-amino-5-iodomethyl-pyrimidine hydroiodide are heated to 120-130 'for 1/2 hour with 5 g of 4-ethyl-5-oxyethylthiazole . The melt is stirred with ether and the remaining powder is recrystallized from alcohol and a little water.

   He holds the hydroiodide of N- (2'-methyl-4 'aminopyrimidyl- [5'] - methyl) -4-ethyl-5-oxyethyl-thiazolium iodide in crystals of F. 212. The compound shows strong anti-neuritic activity.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung einer Thiazo- liumverbindung, dadurch gekennzeichnet, dass man 2-lflethyl-4-amino-5-jodmethyl-pyrimidin- hydrojodid auf 4-Äthyl-5-oxyäthylthiazol ein wirken lässt. Das so erhältliche Hydrojodid des N-(2'- Methyl - 4'- aminopyrimidyl - [5'] - methyl) -4 - äthyl-5-oxyäthyl-thiazoliumjodids bildet Kri stalle vom F. 212 . PATENT CLAIM: Process for the production of a thiazolium compound, characterized in that 2-lflethyl-4-amino-5-iodomethyl-pyrimidine-hydroiodide is allowed to act on 4-ethyl-5-oxyethylthiazole. The thus obtainable hydroiodide of N- (2'-methyl-4'-aminopyrimidyl - [5 '] - methyl) -4 - ethyl-5-oxyethyl-thiazolium iodide forms crystals from F. 212.
CH209821D 1936-01-28 1937-01-08 Process for the preparation of a thiazolium compound. CH209821A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE209821X 1936-01-28
CH202663T 1937-01-08

Publications (1)

Publication Number Publication Date
CH209821A true CH209821A (en) 1940-04-30

Family

ID=25723826

Family Applications (1)

Application Number Title Priority Date Filing Date
CH209821D CH209821A (en) 1936-01-28 1937-01-08 Process for the preparation of a thiazolium compound.

Country Status (1)

Country Link
CH (1) CH209821A (en)

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