CH233764A - Process for the preparation of α-3,5-diiodo-4-oxy-phenyl-α-phenylacetic acid. - Google Patents

Process for the preparation of α-3,5-diiodo-4-oxy-phenyl-α-phenylacetic acid.

Info

Publication number
CH233764A
CH233764A CH233764DA CH233764A CH 233764 A CH233764 A CH 233764A CH 233764D A CH233764D A CH 233764DA CH 233764 A CH233764 A CH 233764A
Authority
CH
Switzerland
Prior art keywords
phenyl
oxy
diiodo
preparation
phenylacetic acid
Prior art date
Application number
Other languages
German (de)
Inventor
Ag Schering
Original Assignee
Ag Schering
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag Schering filed Critical Ag Schering
Publication of CH233764A publication Critical patent/CH233764A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

  Verfahren zur Herstellung von     a-3,5-Dijod-4-oxy-phenyl-a-phenyl-essigsäure.       Gegenstand des     vorliegenden    Patentes     ist,ein     Verfahren zur     Herstellung        .der        a-3,5-Dijod-4-          oxy-phenyl-a-phenyl:-,esss        igsäure,    das dadurch       gekennzeichnet    ist, dass man     a-4-Oxy-phenyl-          a-phenyl-,esssngsäure        mit    einem     jodierenid!en     Mittel behandelt.

   Die neue     Verbindung    soll  insbesondere als     Gallenkontrastmittel    Ver  wendung finden.  



  <I>Beispiel:</I>  22,8     .g        a-4-Oxy-phenyl-a-,phenyl-essig-          säure    werden in 400 cm' normaler Natron  lauge     undi    250     cm@    Wasser ;gelöst und die       Lö.su        ng    ,mit einer solchen. von 51 g Jod, 51 g       Jo@akalium    und 500 cm' Wasser bei gewöhn  licher Temperatur tropfenweise versetzt.  Nach völliger Zugabe wird noch einige     Zeit     gerührt und darauf die jodierte     a-4-Oxy-          phenyl-a-phenyl-essigsäure    durch Zusatz von  schwefliger Säure ausgefällt.

   Der Nieder  schlag wird abgesaugt, mit Wasser aus:ge-    waschen -und aus verdünntem Alkohol um  gelöst. Die erhaltene     a-3,5-Dijod-4-o@xy-          phenyl-a-p,henyl-@essigeäure    schmilzt bei 197 .  Sie     ist    leicht löslich in Alkohol, Aceton und  Äther, schwerer löslich in     .Benzol    und     Toluol,          unlöslich    in     Chloroform    und     Li,groin.  



  Process for the preparation of α-3,5-diiodo-4-oxy-phenyl-α-phenylacetic acid. The subject of the present patent is a process for the production of .der a-3,5-diiodo-4-oxy-phenyl-a-phenyl: -, acetic acid, which is characterized in that a-4-oxy-phenyl- a-phenyl-, acetic acid treated with an iodinated agent.

   The new compound is intended to be used in particular as a biliary contrast medium.



  <I> Example: </I> 22.8 .g a-4-oxy-phenyl-a-, phenyl-acetic acid are dissolved in 400 cm 'normal sodium hydroxide solution and 250 cm @ water; and the solu ng, with such a. 51 g of iodine, 51 g of jo @ kalium and 500 cm of water are added dropwise at normal temperature. After the addition is complete, the mixture is stirred for a while and the iodinated α-4-oxyphenyl-α-phenylacetic acid is then precipitated by adding sulfurous acid.

   The precipitate is sucked off, washed out with water - and redissolved from diluted alcohol. The a-3,5-diiodo-4-o @ xy-phenyl-a-p, henyl- @ acetic acid melts at 197. It is easily soluble in alcohol, acetone and ether, less soluble in benzene and toluene, insoluble in chloroform and lithium, large.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung der a-3,5- Dijod-4-oxy-phenyl-a-phenyl-essibsäure, da- ,durch gekennzeichnet, dass man 4-Oxy- phenyl-ca-ph#enyl-#essigs:äure mit einem jodie renden Mittel behandelt. Die neue Verbindung schmilzt bei 197 . Sie ist leicht löslich in Alkohol, Aceton und Äther, schwerer löslich: in Benzol und Toluo,l, unlöslich in Chloroform und Ligroin. PATENT CLAIM: Process for the preparation of a-3,5-diiodo-4-oxy-phenyl-a-phenyl-acetic acid, characterized in that 4-oxy-phenyl-ca-ph # enyl # acetic acid treated with an iodizing agent. The new compound melts at 197. It is easily soluble in alcohol, acetone and ether, less soluble: in benzene and toluene, l, insoluble in chloroform and ligroin.
CH233764D 1939-05-20 1940-05-18 Process for the preparation of α-3,5-diiodo-4-oxy-phenyl-α-phenylacetic acid. CH233764A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE233764X 1939-05-20
CH220592T 1940-05-18

Publications (1)

Publication Number Publication Date
CH233764A true CH233764A (en) 1944-08-15

Family

ID=25726461

Family Applications (1)

Application Number Title Priority Date Filing Date
CH233764D CH233764A (en) 1939-05-20 1940-05-18 Process for the preparation of α-3,5-diiodo-4-oxy-phenyl-α-phenylacetic acid.

Country Status (1)

Country Link
CH (1) CH233764A (en)

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