CH264135A - Process for the preparation of a basic ether of a p-substituted benzhydrol. - Google Patents

Process for the preparation of a basic ether of a p-substituted benzhydrol.

Info

Publication number
CH264135A
CH264135A CH264135DA CH264135A CH 264135 A CH264135 A CH 264135A CH 264135D A CH264135D A CH 264135DA CH 264135 A CH264135 A CH 264135A
Authority
CH
Switzerland
Prior art keywords
sep
ether
preparation
substituted
basic
Prior art date
Application number
Other languages
German (de)
Inventor
Ag J R Geigy
Original Assignee
Ag J R Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag J R Geigy filed Critical Ag J R Geigy
Publication of CH264135A publication Critical patent/CH264135A/en

Links

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Description

  

  Verfahren zur Herstellung eines basischen Äthers eines     p-substituierten        Benzhydr        ols.     
EMI0001.0004     
  
    Gegenstand <SEP> vorliegenden <SEP> Patentes <SEP> ist. <SEP> ein
<tb>  Verfahren <SEP> zur <SEP> I-lerstellun,- <SEP> eines <SEP> basiseben
<tb>  Äthers <SEP> eines <SEP> 1)-substituierten <SEP> Benzhydrols.
<tb>  Das <SEP> Verfahren <SEP> ist <SEP> dadureh <SEP> bekennzeiehnet,
<tb>  dass <SEP> man <SEP> einen <SEP> p-Methoxy-benzliydryl-(ss-halo  geri-ätliyl)-iither <SEP> mit <SEP> Dimethylamin <SEP> umsetzt.
<tb>  



  Die <SEP> erhaltene <SEP> neue <SEP> Verbindung, <SEP> der <SEP> p-lle  tlioxy-benzhydryl <SEP> -rlimethylaniinoiitliyl-äther,
<tb>  siedet. <SEP> unter <SEP> 0,1 <SEP> min <SEP> Druck <SEP> bei <SEP> 137 <SEP> bis <SEP> 13!l".
<tb>  Sie <SEP> soll <SEP> therapeutisehe <SEP> Verwendung <SEP> finden.

       
EMI0001.0005     
  
    <I>14(2s712el:</I>
<tb>  31,5 <SEP> Teile <SEP> p-llethoxy-benzhy < li;v1-(ss-ehlor  äthyl)-ättier, <SEP> erhältlieh <SEP> dureh <SEP> Umsetzen <SEP> von
<tb>  p-Methoxj#-lienzliydx-yl-hromid <SEP> mit <SEP> Ätliylen  ehlortiy < li-in9 <SEP> werden <SEP> mit <SEP> 10 <SEP> Teilen <SEP> Diinetliyl  amin <SEP> (100 <SEP> j <SEP> ig) <SEP> in <SEP> einem <SEP> Einsehlussrohr <SEP> vier
<tb>  Stunden <SEP> auf <SEP> <B>1100</B> <SEP> erhitzt. <SEP> Darauf <SEP> versetzt
<tb>  man <SEP> das <SEP> Reaktionsprodukt. <SEP> mit <SEP> Wasser <SEP> und
<tb>  säuert <SEP> in <SEP>  < fei- <SEP> Kälte <SEP> finit <SEP> h:

  asi@,süure <SEP> an. <SEP> Die
<tb>  dureh <SEP> Aussehütteln <SEP> mit. <SEP> Äther <SEP> von <SEP> Neutral-            produkten    befreite essigsaure     Lösung    wird  kalt mit.     konz.        Natronlauge        alkaliseh    gestellt  und     ausgeäthert.        Dureh        Eindampfen    wird der  p     -1Ietlioxy    -     benzhydryl    -     dimethylaminoäthyl.-          äther    vom     Kp.".,    137     bis    1390     erbalten.  



  Process for the preparation of a basic ether of a p-substituted benzhydr ol.
EMI0001.0004
  
    The subject of the <SEP> present <SEP> patent <SEP> is. <SEP> on
<tb> Procedure <SEP> for <SEP> I creation, - <SEP> of a <SEP> basic level
<tb> ether <SEP> of a <SEP> 1) -substituted <SEP> benzhydrol.
<tb> The <SEP> method <SEP> is <SEP> because <SEP> is used,
<tb> that <SEP> one <SEP> converts a <SEP> p-methoxy-benzliydryl- (ss-halo geri-ätliyl) -iither <SEP> with <SEP> dimethylamine <SEP>.
<tb>



  The <SEP> received <SEP> new <SEP> compound, <SEP> the <SEP> p-lle tlioxy-benzhydryl <SEP> -rlimethylaniinoiitliyl-ether,
<tb> is boiling. <SEP> under <SEP> 0.1 <SEP> min <SEP> pressure <SEP> at <SEP> 137 <SEP> to <SEP> 13! L ".
<tb> You <SEP> should <SEP> therapeutic <SEP> use <SEP>.

       
EMI0001.0005
  
    <I> 14 (2s712el: </I>
<tb> 31.5 <SEP> parts <SEP> p-llethoxy-benzhy <li; v1- (ss-ehlor äthyl) -ättier, <SEP> obtainable <SEP> through <SEP> conversion <SEP> from
<tb> p-Methoxj # -lienzliydx-yl-hromid <SEP> with <SEP> Ätliylen ehlortiy <li-in9 <SEP> become <SEP> with <SEP> 10 <SEP> parts <SEP> Diinetliyl amin <SEP> (100 <SEP> j <SEP> ig) <SEP> in <SEP> one <SEP> inlet tube <SEP> four
<tb> hours <SEP> heated to <SEP> <B> 1100 </B> <SEP>. <SEP> on top of it <SEP>
<tb> man <SEP> the <SEP> reaction product. <SEP> with <SEP> water <SEP> and
<tb> acidifies <SEP> in <SEP> <fei- <SEP> cold <SEP> finite <SEP> h:

  asi @, süure <SEP> an. <SEP> The
<tb> by <SEP> shaking <SEP> with. <SEP> ether <SEP> freed from <SEP> neutral products, acetic acid solution becomes cold with. conc. Sodium hydroxide solution made alkaline and etherified. By evaporation, the p -1Ietlioxy - benzhydryl - dimethylaminoäthyl.- ether of bp. ", 137-1390 is inherited.

Claims (1)

EMI0001.0021 P <SEP> ATBNT <SEP> ANSPRUCII <tb> Verfahren <SEP> zur <SEP> Herstellung <SEP> eines <SEP> Basisehen <tb> :Wiers <SEP> eines <SEP> p-substituierten <SEP> Benzhyclrols, <SEP> da dureh <SEP> belzennzeiehnet, <SEP> dass <SEP> man <SEP> einen <SEP> p-lIe tlioxy-benzhydrvl-(ss-halogen-äthyl)-äther <SEP> mit <tb> Dimethylamin <SEP> umsetzt. <tb> Die <SEP> erhaltene <SEP> neue <SEP> Verbindung, <SEP> der <SEP> p-Me tlioxy,-beiizliydryl <SEP> -diinethylaniinoä,thyl-ätlier, <tb> siedet <SEP> unter <SEP> 0,1 <SEP> mm <SEP> Druek <SEP> bei <SEP> <B>137</B> <SEP> his <SEP> 139 . <tb> UNTERANSPRUCH: <tb> Verfahren <SEP> naeli <SEP> Patentansprueh, <SEP> dadureh <tb> Olekennzeiehnet, <SEP> dali <SEP> man <SEP> 1-)-lletlioxy-benz h@-dryl-(ss-ch@or-üthyll-üt@ier <SEP> finit <SEP> _Dimethyl amin <SEP> umsetzt. EMI0001.0021 P <SEP> ATBNT <SEP> ANSPRUCII <tb> Procedure <SEP> for the <SEP> production <SEP> of a <SEP> basic marriage <tb>: Wiers <SEP> of a <SEP> p-substituted <SEP> Benzhyclrols, <SEP> because <SEP> denotes, <SEP> that <SEP> one <SEP> a <SEP> p-lIe tlioxy- benzhydrvl- (ss-halogen-ethyl) -ether <SEP> with <tb> Dimethylamine <SEP> converts. <tb> The <SEP> received <SEP> new <SEP> compound, <SEP> the <SEP> p-Metlioxy, -beiizliydryl <SEP> -diinethylaniinoä, thyl-ätlier, <tb> boils <SEP> below <SEP> 0.1 <SEP> mm <SEP> pressure <SEP> with <SEP> <B> 137 </B> <SEP> to <SEP> 139. <tb> SUBClaim: <tb> method <SEP> naeli <SEP> patent claim, <SEP> dadureh <tb> Olekennzeiehnet, <SEP> dali <SEP> man <SEP> 1 -) - lletlioxy-benz h @ -dryl- (ss-ch @ or-üthyll-üt @ ier <SEP> finite <SEP> _Dimethyl amine < SEP> implements.
CH264135D 1947-09-12 1947-09-12 Process for the preparation of a basic ether of a p-substituted benzhydrol. CH264135A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH264135T 1947-09-12

Publications (1)

Publication Number Publication Date
CH264135A true CH264135A (en) 1949-09-30

Family

ID=4475150

Family Applications (1)

Application Number Title Priority Date Filing Date
CH264135D CH264135A (en) 1947-09-12 1947-09-12 Process for the preparation of a basic ether of a p-substituted benzhydrol.

Country Status (1)

Country Link
CH (1) CH264135A (en)

Similar Documents

Publication Publication Date Title
CH264135A (en) Process for the preparation of a basic ether of a p-substituted benzhydrol.
CH269072A (en) Process for the preparation of a basic ether of a p-substituted benzhydrol.
CH269073A (en) Process for the preparation of a basic ether of a p-substituted benzhydrol.
DE360688C (en) Process for the preparation of a derivative of 5íñ5-phenylaethylhydantoin
AT135653B (en) Process for the production of hydrogen peroxide.
DE696556C (en) s formyl cellulose
CH207654A (en) Process for producing a pyrimidine compound.
CH240385A (en) Process for the preparation of an acylated, aliphatic aminocarboxamide.
CH245679A (en) Process for the preparation of a 4-chloro-benzenesulfonamide.
CH250809A (en) Process for the preparation of a new oxyhydrophenanthrene derivative.
CH258207A (en) Process for the preparation of an araliphatic amine.
CH238949A (en) Process for the preparation of a new salt of an amino ester.
CH244952A (en) Process for the preparation of an acylated, aliphatic aminocarboxamide.
CH268088A (en) Process for the preparation of an acylated aliphatic aminocarboxamide.
CH217133A (en) Process for the production of a water-soluble, higher molecular weight, α-substituted benzylamine derivative.
DE1005524B (en) Process for the production of N-methyltaurine sodium
CH178101A (en) Process for the production of a new textile auxiliary.
CH236178A (en) Process for the preparation of p-aminobenzenesulfonyl-butylthiourea.
CH240375A (en) Process for the preparation of an acylated, aliphatic aminocarboxamide.
CH258199A (en) Process for the preparation of a basic ester of a 1-aryl-cycloalkyl-1-carboxylic acid.
CH263544A (en) Process for the production of a new condensation product.
CH252055A (en) Process for the production of a condensation product.
CH240133A (en) Process for the preparation of a basic aralkyl ether.
CH269340A (en) Process for the representation of a basic ether.
CH246415A (en) Process for the production of a trichlorovinyl ketone.