CH291114A - Process for the preparation of a new quaternary ammonium compound. - Google Patents
Process for the preparation of a new quaternary ammonium compound.Info
- Publication number
- CH291114A CH291114A CH291114DA CH291114A CH 291114 A CH291114 A CH 291114A CH 291114D A CH291114D A CH 291114DA CH 291114 A CH291114 A CH 291114A
- Authority
- CH
- Switzerland
- Prior art keywords
- quaternary ammonium
- ammonium compound
- preparation
- new quaternary
- ethyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 4
- 150000003856 quaternary ammonium compounds Chemical class 0.000 title claims description 4
- 238000002360 preparation method Methods 0.000 title description 3
- 230000002567 autonomic effect Effects 0.000 claims description 2
- 210000003403 autonomic nervous system Anatomy 0.000 claims description 2
- 210000003169 central nervous system Anatomy 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims description 2
- 210000000609 ganglia Anatomy 0.000 claims description 2
- 239000000155 melt Substances 0.000 claims description 2
- 230000008844 regulatory mechanism Effects 0.000 claims description 2
- 230000000903 blocking effect Effects 0.000 claims 1
- 229940126601 medicinal product Drugs 0.000 claims 1
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- DAZXVJBJRMWXJP-UHFFFAOYSA-N n,n-dimethylethylamine Chemical compound CCN(C)C DAZXVJBJRMWXJP-UHFFFAOYSA-N 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/62—Quaternary ammonium compounds
- C07C211/63—Quaternary ammonium compounds having quaternised nitrogen atoms bound to acyclic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Verfahren zur Herstellung einer neuen quaternären Anmioniumverbindung. Gegenstand des vorliegenden Patentes ist ein Verfahren zur Herstellung einer neuen quaternären Ammoniumverbindung, welches dadurch gekennzeichnet ist, dass man N-Bis- (ss-brom-äthyl) -N-methyl-amin mit N-Di- methyl-N-äthyl-amin umsetzt. Die Umsetzung wird vorteilhaft in Anwesenheit von Lösungs mitteln, wie Alkohol oder Aceton, durchge führt.
Das so erhaltene N,N,N',N',3-Pentamethyl N,N'-diäthyl-3-aza-pentan-diammonium-dibro- mid schmilzt bei 213 bis 215 . Es besitzt spezi fische Wirkung auf die wichtigen Regulations- meehanismen des autonomen und Zentral-Ner- vensystems, indem es die Funktion der Gan glien blockiert, und kann als Heilmittel Ver wendung finden.
<I>Beispiel:</I> 24,5 Gewichtsteile N-Bis-(f brom-äthyl)- N-methyl-amin werden mit einer Lösung, die in 150 Volumteilen Alkohol 36 Gewichtsteile Dimethyläthylamin enthält, 6 Stunden im Rohr auf 120 erhitzt. Man filtriert, engt bis zur beginnenden Kristallisation ein, versetzt mit Essigester und scheidet so das N,N,N',N', 3-Pentamethyl-N,N'-diäthyl-3-aza-pentan-1,5- diammonium-dibromid vom F. = 213 bis 215 ab.
Es besitzt die Formel
EMI0001.0033
Process for the preparation of a new quaternary ammonium compound. The subject of the present patent is a process for the preparation of a new quaternary ammonium compound, which is characterized in that N-bis- (ß-bromo-ethyl) -N-methyl-amine with N-dimethyl-N-ethyl-amine implements. The reaction is advantageous in the presence of solvents such as alcohol or acetone, Runaway leads.
The N, N, N ', N', 3-pentamethyl N, N'-diethyl-3-aza-pentane-diammonium-dibromide thus obtained melts at 213 to 215. It has a specific effect on the important regulatory mechanisms of the autonomic and central nervous system in that it blocks the function of the ganglia and can be used as a remedy.
<I> Example: </I> 24.5 parts by weight of N-bis- (f-bromo-ethyl) -N-methyl-amine are mixed with a solution containing 36 parts by weight of dimethylethylamine in 150 parts by volume of alcohol for 6 hours in the tube to 120 heated. It is filtered, concentrated until crystallization begins, ethyl acetate is added and the N, N, N ', N', 3-pentamethyl-N, N'-diethyl-3-aza-pentane-1,5-diammonium dibromide from F. = 213 to 215.
It has the formula
EMI0001.0033
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH291114T | 1949-02-15 | ||
| CH284212T | 1949-02-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH291114A true CH291114A (en) | 1953-05-31 |
Family
ID=25732395
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH291114D CH291114A (en) | 1949-02-15 | 1949-02-15 | Process for the preparation of a new quaternary ammonium compound. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH291114A (en) |
-
1949
- 1949-02-15 CH CH291114D patent/CH291114A/en unknown
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