CH299232A - Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane. - Google Patents

Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.

Info

Publication number
CH299232A
CH299232A CH299232DA CH299232A CH 299232 A CH299232 A CH 299232A CH 299232D A CH299232D A CH 299232DA CH 299232 A CH299232 A CH 299232A
Authority
CH
Switzerland
Prior art keywords
bis
quaternary ammonium
alkane
ammonium compound
preparation
Prior art date
Application number
Other languages
German (de)
Inventor
Ag J R Geigy
Original Assignee
Ag J R Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag J R Geigy filed Critical Ag J R Geigy
Publication of CH299232A publication Critical patent/CH299232A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

  Verfahren zur Herstellung einer     quaternären        Ammoniumverbindung     eines     Bis-aminoalkoxy-alkans.       Gegenstand vorliegenden Patentes ist ein  Verfahren zur Herstellung einer     quaternären          Ammoniumverbindung    eines     Bis-aminoalkoxy-          alkans.    Das Verfahren ist dadurch gekenn  zeichnet, dass man auf ein     Mol        1,11-Bis-(ss-di-          äthylamino-äthoxy)-undekan    zwei     Mol        Äthyl-          jodid    einwirken lässt.  



  Die erhaltene neue Verbindung, das 1,11  Bis-     (ss-triäthylammonium-äthoxy)-undekan-          dijodid,    schmilzt bei etwa 128 . Sie soll thera  peutische     Verwendung    finden.  



  <I>Beispiel:</I>  19,3 Teile     1,11-Bis-        (ss-diäthylamino-äthoxy)-          undekan    werden mit 80 Teilen trockenem  Aceton und 19 Teilen     Äthyljodid    14 Stunden  in einem Wasserbad von 50-60  erwärmt.

    Nach Erkalten wird abgesaugt und das     erhal-          texie    1,11 -Bis-(ss-triäthylammonium-äthoxy)-         undekan-dijodid        gewünschtenfalls    durch Um  kristallisieren aus     Butanon        -f-    wenig     abs.    Me  thanol gereinigt, indem das Salz in möglichst  wenig heissem Methanol gelöst und darauf so  viel heisses     Butanon        zugefügt;        wird,    dass in der  Hitze noch alles gelöst bleibt.  



  Das     umkristallisierte    Produkt schmilzt bei  etwa 128 .



  Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane. The present patent is a process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxyalkane. The process is characterized in that one mole of 1,11-bis (ss-diethylamino-ethoxy) -undecane is allowed to act on two moles of ethyl iodide.



  The new compound obtained, the 1,11 bis (ss-triethylammonium ethoxy) undecanediodide, melts at about 128. It should find therapeutic use.



  <I> Example: </I> 19.3 parts of 1,11-bis (ss-diethylamino-ethoxy) - undecane are heated with 80 parts of dry acetone and 19 parts of ethyl iodide for 14 hours in a 50-60 water bath.

    After cooling, the product is filtered off with suction and the obtained texie 1,11-bis- (ss-triethylammonium-ethoxy) - undecane diiodide, if desired, by recrystallizing from butanone -f- a little abs. Methanol is purified by dissolving the salt in as little hot methanol as possible and then adding as much hot butanone; that everything remains resolved in the heat.



  The recrystallized product melts at about 128.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung einer quater- nären Ammoniumverbindung eines Bis-amino- alkoxy-alkans, dadurch gekennzeichnet, dass man auf ein Mol 1,11-Bis-(ss-diäthylamino- äthoxy)-undekan zwei Mol Äthyljodid einwir ken lässt. Die erhaltene neue Verbindung, das 1,11- Bis- (ss-triäthylammonium-äthoxy)-undekan- dijodid, schmilzt bei etwa 128 . Claim: Process for the production of a quaternary ammonium compound of a bis-amino-alkoxy-alkane, characterized in that two moles of ethyl iodide are allowed to act on one mole of 1,11-bis- (ss-diethylamino-ethoxy) -undecane. The new compound obtained, the 1,11-bis (ss-triäthylammonium-ethoxy) -undekanediodide, melts at about 128.
CH299232D 1951-09-20 1951-09-20 Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane. CH299232A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH299232T 1951-09-20
CH290449T 1952-04-21

Publications (1)

Publication Number Publication Date
CH299232A true CH299232A (en) 1954-05-31

Family

ID=25733009

Family Applications (1)

Application Number Title Priority Date Filing Date
CH299232D CH299232A (en) 1951-09-20 1951-09-20 Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.

Country Status (1)

Country Link
CH (1) CH299232A (en)

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