CH302076A - Process for the production of a thiosemicarbazone. - Google Patents
Process for the production of a thiosemicarbazone.Info
- Publication number
- CH302076A CH302076A CH302076DA CH302076A CH 302076 A CH302076 A CH 302076A CH 302076D A CH302076D A CH 302076DA CH 302076 A CH302076 A CH 302076A
- Authority
- CH
- Switzerland
- Prior art keywords
- thiosemicarbazone
- production
- thiosemicarbazide
- yellow crystals
- benzoylbenzaldehyde
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 4
- SRVJKTDHMYAMHA-WUXMJOGZSA-N thioacetazone Chemical compound CC(=O)NC1=CC=C(\C=N\NC(N)=S)C=C1 SRVJKTDHMYAMHA-WUXMJOGZSA-N 0.000 title claims description 4
- 238000004519 manufacturing process Methods 0.000 title claims description 3
- MLZBRARCTFICSV-UHFFFAOYSA-N 4-benzoylbenzaldehyde Chemical compound C1=CC(C=O)=CC=C1C(=O)C1=CC=CC=C1 MLZBRARCTFICSV-UHFFFAOYSA-N 0.000 claims description 3
- 239000013078 crystal Substances 0.000 claims description 3
- BRWIZMBXBAOCCF-UHFFFAOYSA-N hydrazinecarbothioamide Chemical compound NNC(N)=S BRWIZMBXBAOCCF-UHFFFAOYSA-N 0.000 claims description 3
- 150000001875 compounds Chemical group 0.000 claims 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 229960000583 acetic acid Drugs 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000012362 glacial acetic acid Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
Verfahren zur Herstellung eines Thiosemicarbazons. Gegenstand des vorliegenden Patentes ist ein Verfahren zur Herstellung eines neuen, als Arzneimittel verwendbaren Thiosemicarb- azons, das dadurch gekennzeichnet ist, dass man Thiosemicarbazid auf 4-Benzoyl-benzaldehyd oder ein funktionelles Derivat desselben ein wirken lässt.
Das Produkt bildet gelbe, bei 232 schmel zende Kristalle.
<I>Beispiel:</I> 21.g 4-Benzoyl-benzaldehyd werden in 1.00 ein-' Alkohol und 10 cm3 Eisessig gelöst. Unter Rühren fügt man bei 60-70 eine Lö sung von 10 g Thiosemicarbazid in 100 ein- heissem Wasser hinzu und erhitzt 15 Minuten zum Sieden. Das 4-Benzoyl-benzalthiosemicarb- azon fällt nach einiger Zeit aus, wird nach dem Abkühlen abgesaugt und mit Alkohol ge waschen.
Durch Umkristallisieren aus Alkohol erhält man es in Form gelber Kristalle, die bei 232 schmelzen. Die Ausbeute ist fast quantitativ.
Process for the production of a thiosemicarbazone. The subject of the present patent is a process for the preparation of a new thiosemicarbazone which can be used as a medicament and which is characterized in that thiosemicarbazide is allowed to act on 4-benzoylbenzaldehyde or a functional derivative thereof.
The product forms yellow crystals melting at 232.
<I> Example: </I> 21.g of 4-benzoyl-benzaldehyde are dissolved in 1.00 one-alcohol and 10 cm3 glacial acetic acid. A solution of 10 g of thiosemicarbazide in 100% of hot water is added at 60-70 with stirring and the mixture is heated to the boil for 15 minutes. The 4-benzoyl-benzalthiosemicarbazone precipitates after a while, is filtered off with suction after cooling and washed with alcohol.
Recrystallization from alcohol gives it the form of yellow crystals that melt at 232. The yield is almost quantitative.
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE302076X | 1950-10-11 | ||
| CH299877T | 1951-10-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH302076A true CH302076A (en) | 1954-09-30 |
Family
ID=25734123
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH302076D CH302076A (en) | 1950-10-11 | 1951-10-04 | Process for the production of a thiosemicarbazone. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH302076A (en) |
-
1951
- 1951-10-04 CH CH302076D patent/CH302076A/en unknown
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