CH310732A - Process for the preparation of a bactericidal salicylanilide. - Google Patents
Process for the preparation of a bactericidal salicylanilide.Info
- Publication number
- CH310732A CH310732A CH310732DA CH310732A CH 310732 A CH310732 A CH 310732A CH 310732D A CH310732D A CH 310732DA CH 310732 A CH310732 A CH 310732A
- Authority
- CH
- Switzerland
- Prior art keywords
- bactericidal
- preparation
- salicylanilide
- oxy
- chloro
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 5
- 230000000844 anti-bacterial effect Effects 0.000 title claims description 4
- 238000002360 preparation method Methods 0.000 title description 3
- WKEDVNSFRWHDNR-UHFFFAOYSA-N salicylanilide Chemical compound OC1=CC=CC=C1C(=O)NC1=CC=CC=C1 WKEDVNSFRWHDNR-UHFFFAOYSA-N 0.000 title 1
- 229950000975 salicylanilide Drugs 0.000 title 1
- 239000000155 melt Substances 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims 1
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- MVPPADPHJFYWMZ-UHFFFAOYSA-N chlorobenzene Chemical compound ClC1=CC=CC=C1 MVPPADPHJFYWMZ-UHFFFAOYSA-N 0.000 description 2
- RRJUYQOFOMFVQS-UHFFFAOYSA-N 2,3,4-trichloroaniline Chemical compound NC1=CC=C(Cl)C(Cl)=C1Cl RRJUYQOFOMFVQS-UHFFFAOYSA-N 0.000 description 1
- XNWFRZJHXBZDAG-UHFFFAOYSA-N 2-METHOXYETHANOL Chemical compound COCCO XNWFRZJHXBZDAG-UHFFFAOYSA-N 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- FAIAAWCVCHQXDN-UHFFFAOYSA-N phosphorus trichloride Chemical compound ClP(Cl)Cl FAIAAWCVCHQXDN-UHFFFAOYSA-N 0.000 description 1
- UIIMBOGNXHQVGW-UHFFFAOYSA-N sodium;hydron;carbonate Chemical compound [Na+].OC(O)=O UIIMBOGNXHQVGW-UHFFFAOYSA-N 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Description
Verfahren zur Herstellung eines bakteriziden Salieylanilides. Glegenstand vorliegenden Patentes ist ein Verfahren zur Herstellung eines bakteriziden Salieylanilides. Das Verfahren ist dadurch ge kennzeichnet, dass man 1 1lol 5-Chlor-2-oxy- benzol-l-carbonsäure auf 1 Mol 2,3,4-Triehlor- anilin einwirken lässt.
Die erhaltene neue Verbindung, das 5- '1i1 oi, -'- oxy- benzoyl - 2', 3',4' - trichlor - anilid, schmilzt bei 248-249 . Sie soll als Desinfek- t ionsmittel für nicht arzneiliche Zwecke Ver wendung finden.
<I>Beispiel:</I> 18 Teile 5-Chlor-2-oxy-benzol-l-carbonsäure, 19,5 Teile 2,3,4-Trichlor-anilin, 0,4 Teile Alu- ininiumchlorid und 6 Teile Phosphortrichlorid werden in 400 Volumteilen Chlorbenzol suspen- diert und so lange zum Sieden erhitzt, bis klare Lösung eingetreten ist. Es wird heiss fil triert, mit Soda. neutralisiert und das Lö sungsmittel mit Wasserdampf abgetrieben.
Das aus Äthylenglykolmonomethyläther um kristallisierte 5-Chlor-2-oxy-benzoyl-2',3',4'-tri- chlor-anilid schmilzt bei 248-249 .
Process for the preparation of a bactericidal salieylanilide. The subject of the present patent is a process for the preparation of a bactericidal salieylanilide. The process is characterized in that 1 lol of 5-chloro-2-oxybenzene-1-carboxylic acid is allowed to act on 1 mol of 2,3,4-triehloroaniline.
The new compound obtained, the 5- '1i1 oi, -'- oxy-benzoyl - 2', 3 ', 4' - trichloro - anilide, melts at 248-249. It is intended to be used as a disinfectant for non-medicinal purposes.
<I> Example: </I> 18 parts of 5-chloro-2-oxy-benzene-1-carboxylic acid, 19.5 parts of 2,3,4-trichloroaniline, 0.4 part of aluminum chloride and 6 parts of phosphorus trichloride are suspended in 400 parts by volume of chlorobenzene and heated to boiling until a clear solution has occurred. It is filtered hot, with soda. neutralized and the solvent driven off with water vapor.
The 5-chloro-2-oxy-benzoyl-2 ', 3', 4'-trichloro-anilide crystallized from ethylene glycol monomethyl ether melts at 248-249.
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH304558T | 1951-12-29 | ||
| CH310732T | 1952-11-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH310732A true CH310732A (en) | 1955-10-31 |
Family
ID=25734866
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH310732D CH310732A (en) | 1951-12-29 | 1952-11-28 | Process for the preparation of a bactericidal salicylanilide. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH310732A (en) |
-
1952
- 1952-11-28 CH CH310732D patent/CH310732A/en unknown
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