CH312052A - Process for the preparation of a diammonium compound. - Google Patents

Process for the preparation of a diammonium compound.

Info

Publication number
CH312052A
CH312052A CH312052DA CH312052A CH 312052 A CH312052 A CH 312052A CH 312052D A CH312052D A CH 312052DA CH 312052 A CH312052 A CH 312052A
Authority
CH
Switzerland
Prior art keywords
bis
hexyl
preparation
mol
ïthoxy
Prior art date
Application number
Other languages
German (de)
Inventor
Ag J R Geigy
Original Assignee
Ag J R Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag J R Geigy filed Critical Ag J R Geigy
Publication of CH312052A publication Critical patent/CH312052A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/62—Quaternary ammonium compounds
    • C07C211/63—Quaternary ammonium compounds having quaternised nitrogen atoms bound to acyclic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

  



  Verfahren zur Herstellung einer Diammoniumverbindung.



   Gegenstand des vorliegenden Patentes ist ein Verfahren zur   Herstellung    einer Diammo  niumverbindung,    welches dadurch   gekenn-    zeichnet ist, dass man 1 Mol   1,      8-Bis-    (¯-dimethylamino-Ïthoxy)-octan mit 2 Mol n  Hexylbromid    umsetzt.



   Die erhaltene neue Verbindung, das 1, 8 Bis- [¯-(n-hexyl-dimethyl-ammonium)-Ïthoxy]  octan-dibromid, schmilzt    bei   130 .    Sie soll als Arzneimittel und als Zwischenprodukt f r Arzneimittel Verwendung finden.



   Beispiel :
3, 1 Teile   1,    8-Bis-(¯-dimethylamino-Ïthoxy)oetan werden in 20 Volumteilen Aceton gelöst, mit 3, 8 Teilen n-Hexylbromid (Molver  hältnis      1    : 2, 3) versetzt und etwa 14   Stunden    am Rückfluss erhitzt. Beim Stehenlassen kristallisiert das   diquartäre    Salz aus. Nach Umkristallisieren aus wenig abs. Methanol unter Zusatz von Butanon, schmilzt das 1, 8-Bis-[¯    (n-hexyl-dimethyl-ammonium)-äthoxy]-octan-    dibromid bei   130 .   



     PATENTANSPRUCII    :
Verfahren zur Herstellung einer Diammo  niumverbindung,    dadurch gekennzeichnet, dass man 1 Mol   1,    8-Bis-(¯-dimethylamino-Ïthoxy)oetan mit 2 Mol n-Hexylbromid umsetzt.  



   Die erhaltene neue Verbindung, das 1, 8 Bis-   [p-(n-hexyl-dimethyl-ammonium)-äthoxy]-    oetan-dibromid, schmilzt bei   130 .    

**WARNUNG** Ende DESC Feld konnte Anfang CLMS uberlappen**.





  



  Process for the preparation of a diammonium compound.



   The subject of the present patent is a process for the preparation of a diammonium compound which is characterized in that 1 mol of 1,8-bis (¯-dimethylamino-ethoxy) octane is reacted with 2 mol of n-hexyl bromide.



   The new compound obtained, 1.8 bis- [¯- (n-hexyl-dimethyl-ammonium) -Ïthoxy] octane dibromide, melts at 130. It should be used as a drug and as an intermediate for drugs.



   Example:
3.1 parts of 1,8-bis- (¯-dimethylamino-Ïthoxy) oetane are dissolved in 20 parts by volume of acetone, mixed with 3.8 parts of n-hexyl bromide (molar ratio 1: 2, 3) and refluxed for about 14 hours . When left to stand, the diquartary salt crystallizes out. After recrystallization from a little abs. Methanol with the addition of butanone, the 1,8-bis [¯ (n-hexyl-dimethyl-ammonium) -ethoxy] -octanedibromide melts at 130.



     PATENT CLAIM:
Process for the preparation of a diammonium compound, characterized in that 1 mol of 1,8-bis (¯-dimethylamino-Ïthoxy) oetane is reacted with 2 mol of n-hexyl bromide.



   The new compound obtained, 1.8 bis- [p- (n-hexyl-dimethyl-ammonium) -ethoxy] -oetane dibromide, melts at 130.

** WARNING ** End of DESC field could overlap beginning of CLMS **.

Claims (1)

**WARNUNG** Anfang CLMS Feld konnte Ende DESC uberlappen **. ** WARNING ** Beginning of CLMS field could overlap end of DESC **. Verfahren zur Herstellung einer Diammoniumverbindung. Process for the preparation of a diammonium compound. Gegenstand des vorliegenden Patentes ist ein Verfahren zur Herstellung einer Diammo niumverbindung, welches dadurch gekenn- zeichnet ist, dass man 1 Mol 1, 8-Bis- (¯-dimethylamino-Ïthoxy)-octan mit 2 Mol n Hexylbromid umsetzt. The subject of the present patent is a process for the preparation of a diammonium compound which is characterized in that 1 mol of 1,8-bis (¯-dimethylamino-ethoxy) octane is reacted with 2 mol of n-hexyl bromide. Die erhaltene neue Verbindung, das 1, 8 Bis- [¯-(n-hexyl-dimethyl-ammonium)-Ïthoxy] octan-dibromid, schmilzt bei 130 . Sie soll als Arzneimittel und als Zwischenprodukt f r Arzneimittel Verwendung finden. The new compound obtained, 1.8 bis- [¯- (n-hexyl-dimethyl-ammonium) -Ïthoxy] octane dibromide, melts at 130. It should be used as a drug and as an intermediate for drugs. Beispiel : 3, 1 Teile 1, 8-Bis-(¯-dimethylamino-Ïthoxy)oetan werden in 20 Volumteilen Aceton gelöst, mit 3, 8 Teilen n-Hexylbromid (Molver hältnis 1 : 2, 3) versetzt und etwa 14 Stunden am Rückfluss erhitzt. Beim Stehenlassen kristallisiert das diquartäre Salz aus. Nach Umkristallisieren aus wenig abs. Methanol unter Zusatz von Butanon, schmilzt das 1, 8-Bis-[¯ (n-hexyl-dimethyl-ammonium)-äthoxy]-octan- dibromid bei 130 . Example: 3.1 parts of 1,8-bis- (¯-dimethylamino-Ïthoxy) oetane are dissolved in 20 parts by volume of acetone, mixed with 3.8 parts of n-hexyl bromide (molar ratio 1: 2, 3) and refluxed for about 14 hours . When left to stand, the diquartary salt crystallizes out. After recrystallization from a little abs. Methanol with the addition of butanone, the 1,8-bis [¯ (n-hexyl-dimethyl-ammonium) -ethoxy] -octanedibromide melts at 130. PATENTANSPRUCII : Verfahren zur Herstellung einer Diammo niumverbindung, dadurch gekennzeichnet, dass man 1 Mol 1, 8-Bis-(¯-dimethylamino-Ïthoxy)oetan mit 2 Mol n-Hexylbromid umsetzt. PATENT CLAIM: Process for the preparation of a diammonium compound, characterized in that 1 mol of 1,8-bis (¯-dimethylamino-Ïthoxy) oetane is reacted with 2 mol of n-hexyl bromide. Die erhaltene neue Verbindung, das 1, 8 Bis- [p-(n-hexyl-dimethyl-ammonium)-äthoxy]- oetan-dibromid, schmilzt bei 130 . The new compound obtained, 1.8 bis- [p- (n-hexyl-dimethyl-ammonium) -ethoxy] -oetane dibromide, melts at 130.
CH312052D 1952-06-13 1952-06-13 Process for the preparation of a diammonium compound. CH312052A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH312052T 1952-06-13
CH308688T 1955-07-31

Publications (1)

Publication Number Publication Date
CH312052A true CH312052A (en) 1955-12-15

Family

ID=25735507

Family Applications (1)

Application Number Title Priority Date Filing Date
CH312052D CH312052A (en) 1952-06-13 1952-06-13 Process for the preparation of a diammonium compound.

Country Status (1)

Country Link
CH (1) CH312052A (en)

Similar Documents

Publication Publication Date Title
CH312050A (en) Process for the preparation of a diammonium compound.
CH312051A (en) Process for the preparation of a diammonium compound.
CH312049A (en) Process for the preparation of a diammonium compound.
CH218517A (en) Process for the preparation of 1-methyl-4-phenyl-piperidyl-4-isopropyl-ketone.
CH312055A (en) Process for the preparation of a diammonium compound.
CH312054A (en) Process for the preparation of a diammonium compound.
CH236172A (en) Process for the preparation of 4-amino-benzenesulfone-2'-isopropylmercapto-benzamide.
CH306512A (en) Process for the preparation of a basic substituted fatty acid (2-halo-6-methyl) anilide.
CH310719A (en) Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.
CH240726A (en) Process for the preparation of a p-amino-benzenesulfonamide.
CH307562A (en) Process for the preparation of a diammonium compound.
CH311590A (en) Process for making a new salt.
CH279100A (en) Process for the preparation of a B-pyridyl-carbinol salt.
CH306913A (en) Process for the preparation of a diammonium compound.
CH296241A (en) Process for the preparation of N-acrylaminoacetic acid.
CH293930A (en) Process for the preparation of a quaternary ammonium compound of a bis-aminoalkoxy-alkane.
CH300831A (en) Process for the preparation of an N-acyl derivative of iminodibenzyl.
CH316629A (en) Process for the preparation of a hydrazone of a heterocyclic aldehyde
CH267813A (en) Process for the preparation of a derivative of pantothenic acid.
CH235515A (en) Process for the preparation of tetrahydropyran-4,4-dicarboxylic acid-bis-diethylamide.
CH307563A (en) Process for the preparation of a diammonium compound.
CH300417A (en) Process for the preparation of a derivative of 3- (4'-oxy-phenyl) -3- (4 "-oxy-3" -aminomethyl-phenyl) -oxindole.
CH298783A (en) Process for the preparation of a diquartar diammonium salt.
CH307564A (en) Process for the preparation of a diammonium compound.
CH490329A (en) Process for the preparation of a new cyclobutene derivative