CH377368A - Verfahren zur Reinigung von 1(+)-Lysin - Google Patents
Verfahren zur Reinigung von 1(+)-LysinInfo
- Publication number
- CH377368A CH377368A CH394160A CH394160A CH377368A CH 377368 A CH377368 A CH 377368A CH 394160 A CH394160 A CH 394160A CH 394160 A CH394160 A CH 394160A CH 377368 A CH377368 A CH 377368A
- Authority
- CH
- Switzerland
- Prior art keywords
- lysine monohydrochloride
- lysine
- monohydrochloride
- solution
- temperature
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 11
- KDXKERNSBIXSRK-UHFFFAOYSA-N lysine Chemical compound NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 title description 3
- 238000000746 purification Methods 0.000 title description 2
- BVHLGVCQOALMSV-JEDNCBNOSA-N L-lysine hydrochloride Chemical compound Cl.NCCCC[C@H](N)C(O)=O BVHLGVCQOALMSV-JEDNCBNOSA-N 0.000 claims description 39
- BVHLGVCQOALMSV-UHFFFAOYSA-N (5-amino-1-carboxypentyl)azanium;chloride Chemical compound Cl.NCCCCC(N)C(O)=O BVHLGVCQOALMSV-UHFFFAOYSA-N 0.000 claims description 19
- 239000000243 solution Substances 0.000 claims description 17
- 230000003287 optical effect Effects 0.000 claims description 14
- 239000012452 mother liquor Substances 0.000 claims description 9
- 239000007864 aqueous solution Substances 0.000 claims description 5
- 238000002425 crystallisation Methods 0.000 claims description 5
- 230000008025 crystallization Effects 0.000 claims description 5
- 238000001704 evaporation Methods 0.000 claims description 4
- 230000008020 evaporation Effects 0.000 claims description 4
- 229920006395 saturated elastomer Polymers 0.000 claims description 4
- 238000001816 cooling Methods 0.000 claims description 3
- 230000001419 dependent effect Effects 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000001694 spray drying Methods 0.000 claims 1
- 239000013078 crystal Substances 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- WVFFJPIHHMRANW-BHRFRFAJSA-N (2S)-2,6-diaminohexanoic acid dihydrate hydrochloride Chemical compound O.O.Cl.NCCCC[C@H](N)C(O)=O WVFFJPIHHMRANW-BHRFRFAJSA-N 0.000 description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 150000002306 glutamic acid derivatives Chemical class 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 150000004683 dihydrates Chemical class 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- HOMROMWVNDUGRI-RVZXSAGBSA-N (2s)-2-aminopentanedioic acid;(2s)-2,6-diaminohexanoic acid Chemical compound NCCCC[C@H](N)C(O)=O.OC(=O)[C@@H](N)CCC(O)=O HOMROMWVNDUGRI-RVZXSAGBSA-N 0.000 description 1
- KDXKERNSBIXSRK-RXMQYKEDSA-N D-lysine Chemical compound NCCCC[C@@H](N)C(O)=O KDXKERNSBIXSRK-RXMQYKEDSA-N 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000001640 fractional crystallisation Methods 0.000 description 1
- 229930195712 glutamate Natural products 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 229960003646 lysine Drugs 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH394160A CH377368A (de) | 1960-04-07 | 1960-04-07 | Verfahren zur Reinigung von 1(+)-Lysin |
| GB11534/61A GB963265A (en) | 1960-04-07 | 1961-03-29 | Process for purifying l(+)-lysine |
| BE602174A BE602174A (fr) | 1960-04-07 | 1961-04-04 | Procédé de purification de la 1(+)-lysine. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH394160A CH377368A (de) | 1960-04-07 | 1960-04-07 | Verfahren zur Reinigung von 1(+)-Lysin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH377368A true CH377368A (de) | 1964-05-15 |
Family
ID=4266770
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH394160A CH377368A (de) | 1960-04-07 | 1960-04-07 | Verfahren zur Reinigung von 1(+)-Lysin |
Country Status (3)
| Country | Link |
|---|---|
| BE (1) | BE602174A (fr) |
| CH (1) | CH377368A (fr) |
| GB (1) | GB963265A (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL6700368A (fr) * | 1967-01-11 | 1968-07-12 | ||
| PT95564B (pt) * | 1989-10-17 | 1997-11-28 | Merck & Co Inc | Processo para a preparacao de (+)-ibuprofen-d-aminoacido uteis como analgesicos intensificados de ataque acelerado |
-
1960
- 1960-04-07 CH CH394160A patent/CH377368A/de unknown
-
1961
- 1961-03-29 GB GB11534/61A patent/GB963265A/en not_active Expired
- 1961-04-04 BE BE602174A patent/BE602174A/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BE602174A (fr) | 1961-07-31 |
| GB963265A (en) | 1964-07-08 |
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