CH413811A - Verfahren zur Herstellung von hydrophilen Erzeugnissen von hohem Molekulargewicht aus Dextransubstanzen - Google Patents

Verfahren zur Herstellung von hydrophilen Erzeugnissen von hohem Molekulargewicht aus Dextransubstanzen

Info

Publication number: CH413811A
Authority: CH; Switzerland
Prior art keywords: dextran; molecular weight; substance; product; reaction
Prior art date: 1958-03-13

Application number

CH7074659A

Other languages

German (de)

English (en)

Inventor

Magnus Flodin Per Gustaf

Gustaf-Adolf Ingelman Bjorn

Original Assignee

Pharmacia Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1958-03-13

Filing date

1959-03-12

Publication date

1966-05-31

1959-03-12 Application filed by Pharmacia Ab filed Critical Pharmacia Ab

1966-05-31 Publication of CH413811A publication Critical patent/CH413811A/de

Links

229920002307 Dextran Polymers 0.000 title claims description 68
239000000126 substance Substances 0.000 title claims description 45
238000000034 method Methods 0.000 title claims description 24
230000008569 process Effects 0.000 title claims description 5
238000002360 preparation method Methods 0.000 title description 4
239000000047 product Substances 0.000 claims description 89
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 35
239000000243 solution Substances 0.000 claims description 33
238000006243 chemical reaction Methods 0.000 claims description 24
BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 claims description 18
230000001588 bifunctional effect Effects 0.000 claims description 12
238000000227 grinding Methods 0.000 claims description 11
238000006116 polymerization reaction Methods 0.000 claims description 9
238000005194 fractionation Methods 0.000 claims description 7
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 7
238000004519 manufacturing process Methods 0.000 claims description 7
RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 6
239000002904 solvent Substances 0.000 claims description 6
239000007864 aqueous solution Substances 0.000 claims description 5
230000015572 biosynthetic process Effects 0.000 claims description 5
239000007795 chemical reaction product Substances 0.000 claims description 5
230000007062 hydrolysis Effects 0.000 claims description 5
238000006460 hydrolysis reaction Methods 0.000 claims description 5
238000002347 injection Methods 0.000 claims description 5
239000007924 injection Substances 0.000 claims description 5
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 4
125000003277 amino group Chemical group 0.000 claims description 4
230000002378 acidificating effect Effects 0.000 claims description 3
239000003513 alkali Substances 0.000 claims description 3
DEWLEGDTCGBNGU-UHFFFAOYSA-N 1,3-dichloropropan-2-ol Chemical compound ClCC(O)CCl DEWLEGDTCGBNGU-UHFFFAOYSA-N 0.000 claims description 2
239000002253 acid Substances 0.000 claims description 2
125000003700 epoxy group Chemical group 0.000 claims description 2
235000011187 glycerol Nutrition 0.000 claims description 2
125000005843 halogen group Chemical group 0.000 claims description 2
230000001537 neural effect Effects 0.000 claims description 2
238000001556 precipitation Methods 0.000 claims description 2
230000001419 dependent effect Effects 0.000 claims 2
229910052784 alkaline earth metal Inorganic materials 0.000 claims 1
150000001342 alkaline earth metals Chemical class 0.000 claims 1
230000003197 catalytic effect Effects 0.000 claims 1
GKIPXFAANLTWBM-UHFFFAOYSA-N epibromohydrin Chemical compound BrCC1CO1 GKIPXFAANLTWBM-UHFFFAOYSA-N 0.000 claims 1
235000020075 ouzo Nutrition 0.000 claims 1
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 53
239000000499 gel Substances 0.000 description 29
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 19
238000005406 washing Methods 0.000 description 14
238000001035 drying Methods 0.000 description 13
238000010438 heat treatment Methods 0.000 description 10
235000019441 ethanol Nutrition 0.000 description 7
239000002245 particle Substances 0.000 description 7
238000006386 neutralization reaction Methods 0.000 description 6
230000003472 neutralizing effect Effects 0.000 description 5
238000011084 recovery Methods 0.000 description 5
238000004140 cleaning Methods 0.000 description 4
LSTZTHCEEPHCNQ-UHFFFAOYSA-N 3-(2,5-dioxabicyclo[2.1.0]pentan-3-yloxy)-2,5-dioxabicyclo[2.1.0]pentane Chemical compound C1(C2C(O2)O1)OC1C2C(O2)O1 LSTZTHCEEPHCNQ-UHFFFAOYSA-N 0.000 description 3
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 3
-1 epichloro- Chemical class 0.000 description 3
238000002474 experimental method Methods 0.000 description 3
229930182470 glycoside Natural products 0.000 description 3
150000002500 ions Chemical class 0.000 description 3
238000003801 milling Methods 0.000 description 3
239000003058 plasma substitute Substances 0.000 description 3
238000000746 purification Methods 0.000 description 3
150000003254 radicals Chemical group 0.000 description 3
238000001226 reprecipitation Methods 0.000 description 3
238000007086 side reaction Methods 0.000 description 3
ZFIVKAOQEXOYFY-UHFFFAOYSA-N Diepoxybutane Chemical compound C1OC1C1OC1 ZFIVKAOQEXOYFY-UHFFFAOYSA-N 0.000 description 2
210000004204 blood vessel Anatomy 0.000 description 2
WERYXYBDKMZEQL-UHFFFAOYSA-N butane-1,4-diol Chemical compound OCCCCO WERYXYBDKMZEQL-UHFFFAOYSA-N 0.000 description 2
239000003054 catalyst Substances 0.000 description 2
239000003795 chemical substances by application Substances 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
238000001816 cooling Methods 0.000 description 2
238000009792 diffusion process Methods 0.000 description 2
238000009826 distribution Methods 0.000 description 2
239000000203 mixture Substances 0.000 description 2
239000003960 organic solvent Substances 0.000 description 2
229920000642 polymer Polymers 0.000 description 2
230000008961 swelling Effects 0.000 description 2
AZUXKVXMJOIAOF-UHFFFAOYSA-N 1-(2-hydroxypropoxy)propan-2-ol Chemical class CC(O)COCC(C)O AZUXKVXMJOIAOF-UHFFFAOYSA-N 0.000 description 1
FSBYOEHUNSUUTD-UHFFFAOYSA-N 2-(2,5-dioxabicyclo[2.1.0]pentan-3-yloxy)ethanol Chemical compound C1(C2C(O2)O1)OCCO FSBYOEHUNSUUTD-UHFFFAOYSA-N 0.000 description 1
KNDAEDDIIQYRHY-UHFFFAOYSA-N 2-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]-3-(piperazin-1-ylmethyl)pyrazol-1-yl]-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C=1C(=NN(C=1)CC(=O)N1CC2=C(CC1)NN=N2)CN1CCNCC1 KNDAEDDIIQYRHY-UHFFFAOYSA-N 0.000 description 1
102000013142 Amylases Human genes 0.000 description 1
108010065511 Amylases Proteins 0.000 description 1
LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 description 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
239000004593 Epoxy Substances 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
230000009471 action Effects 0.000 description 1
230000004520 agglutination Effects 0.000 description 1
125000003158 alcohol group Chemical group 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
238000006136 alcoholysis reaction Methods 0.000 description 1
125000001931 aliphatic group Chemical group 0.000 description 1
229910001854 alkali hydroxide Inorganic materials 0.000 description 1
229910001860 alkaline earth metal hydroxide Inorganic materials 0.000 description 1
235000019418 amylase Nutrition 0.000 description 1
229940025131 amylases Drugs 0.000 description 1
238000000149 argon plasma sintering Methods 0.000 description 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
239000008280 blood Substances 0.000 description 1
210000000601 blood cell Anatomy 0.000 description 1
230000023555 blood coagulation Effects 0.000 description 1
AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
239000000920 calcium hydroxide Substances 0.000 description 1
229910001861 calcium hydroxide Inorganic materials 0.000 description 1
229910052799 carbon Inorganic materials 0.000 description 1
239000000470 constituent Substances 0.000 description 1
230000008878 coupling Effects 0.000 description 1
238000010168 coupling process Methods 0.000 description 1
238000005859 coupling reaction Methods 0.000 description 1
238000000502 dialysis Methods 0.000 description 1
125000003963 dichloro group Chemical group Cl* 0.000 description 1
239000007884 disintegrant Substances 0.000 description 1
230000000694 effects Effects 0.000 description 1
210000003743 erythrocyte Anatomy 0.000 description 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
238000001704 evaporation Methods 0.000 description 1
230000008020 evaporation Effects 0.000 description 1
238000000605 extraction Methods 0.000 description 1
239000000945 filler Substances 0.000 description 1
125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
150000002314 glycerols Chemical class 0.000 description 1
150000002338 glycosides Chemical class 0.000 description 1
150000003944 halohydrins Chemical class 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
150000002431 hydrogen Chemical class 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
229910000039 hydrogen halide Inorganic materials 0.000 description 1
239000012433 hydrogen halide Substances 0.000 description 1
239000012535 impurity Substances 0.000 description 1
235000015110 jellies Nutrition 0.000 description 1
239000008274 jelly Substances 0.000 description 1
150000002576 ketones Chemical class 0.000 description 1
230000003907 kidney function Effects 0.000 description 1
239000008141 laxative Substances 0.000 description 1
229940125722 laxative agent Drugs 0.000 description 1
231100000053 low toxicity Toxicity 0.000 description 1
239000012452 mother liquor Substances 0.000 description 1
229910052760 oxygen Inorganic materials 0.000 description 1
239000001301 oxygen Substances 0.000 description 1
230000035699 permeability Effects 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
239000000843 powder Substances 0.000 description 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
230000009103 reabsorption Effects 0.000 description 1
230000035484 reaction time Effects 0.000 description 1
230000009467 reduction Effects 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
230000000405 serological effect Effects 0.000 description 1
238000007873 sieving Methods 0.000 description 1
239000010802 sludge Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011734 sodium Substances 0.000 description 1
239000007787 solid Substances 0.000 description 1
230000000087 stabilizing effect Effects 0.000 description 1
239000007858 starting material Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
239000002699 waste material Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
- B01J39/08—Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
- B01J39/16—Organic material
- B01J39/18—Macromolecular compounds
- B01J39/22—Cellulose or wood; Derivatives thereof

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Materials Engineering (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Polymers & Plastics (AREA)
General Health & Medical Sciences (AREA)
Wood Science & Technology (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)

CH7074659A 1958-03-13 1959-03-12 Verfahren zur Herstellung von hydrophilen Erzeugnissen von hohem Molekulargewicht aus Dextransubstanzen CH413811A (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE245258A SE169293C1 (fr)	1958-03-13	1958-03-13

Publications (1)

Publication Number	Publication Date
CH413811A true CH413811A (de)	1966-05-31

Family

ID=20259979

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CH7074659A CH413811A (de)	1958-03-13	1959-03-12	Verfahren zur Herstellung von hydrophilen Erzeugnissen von hohem Molekulargewicht aus Dextransubstanzen

Country Status (5)

Country	Link
BE (1)	BE576522A (fr)
CH (1)	CH413811A (fr)
DE (1)	DE1418013A1 (fr)
GB (1)	GB854715A (fr)
SE (1)	SE169293C1 (fr)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE358894B (fr) *	1961-10-25	1973-08-13	Pharmacia Ab
US4537767A (en) *	1973-01-29	1985-08-27	Pharmacia Aktiebolag	Method for cleansing fluid discharging skin surfaces, wounds and mucous membranes and means for carrying out the method
SE452109B (sv) *	1973-01-29	1987-11-16	Pharmacia Ab	Rengoringsmedel for vetskande utvertes sarytor
US4470975A (en) *	1977-10-21	1984-09-11	The Johns Hopkins University	Method and composition for the elimination of water from an animal body
SE445116B (sv) *	1979-09-12	1986-06-02	Pharmacia Fine Chemicals Ab	Sett att odla celler pa mikroberare med fibronektinytskikt
SE456346B (sv) *	1984-07-23	1988-09-26	Pharmacia Ab	Gel for att forhindra adhesion mellan kroppsvevnader och sett for dess framstellning
SE452469B (sv) *	1986-06-18	1987-11-30	Pharmacia Ab	Material bestaende av en tverbunden karboxylgrupphaltig polysackarid och forfarande vid framstellning av detsamma
US5585007A (en)	1994-12-07	1996-12-17	Plasmaseal Corporation	Plasma concentrate and tissue sealant methods and apparatuses for making concentrated plasma and/or tissue sealant
GB9920732D0 (en) *	1999-09-03	1999-11-03	Sulzer Vascutek Ltd	Sealant
AU2002361902A1 (en)	2001-12-31	2003-07-24	Ares Medical, Inc.	Hemostatic compositions and methods for controlling bleeding
US7374678B2 (en)	2002-05-24	2008-05-20	Biomet Biologics, Inc.	Apparatus and method for separating and concentrating fluids containing multiple components
US7832566B2 (en)	2002-05-24	2010-11-16	Biomet Biologics, Llc	Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles
US7992725B2 (en)	2002-05-03	2011-08-09	Biomet Biologics, Llc	Buoy suspension fractionation system
US20030205538A1 (en)	2002-05-03	2003-11-06	Randel Dorian	Methods and apparatus for isolating platelets from blood
DE10392686T5 (de)	2002-05-24	2005-07-07	Biomet Mfg. Corp., Warsaw	Vorrichtung und Verfahren zum Trennen und Konzentrieren von Flüssigkeiten, welche mehrere Komponenten enthalten
US20060278588A1 (en)	2002-05-24	2006-12-14	Woodell-May Jennifer E	Apparatus and method for separating and concentrating fluids containing multiple components
US7845499B2 (en)	2002-05-24	2010-12-07	Biomet Biologics, Llc	Apparatus and method for separating and concentrating fluids containing multiple components
WO2006086201A2 (fr)	2005-02-07	2006-08-17	Hanuman Llc	Appareil et procede de concentration de plasma riche en plaquettes
WO2006086199A1 (fr)	2005-02-07	2006-08-17	Hanuman Llc	Appareil et procede de preparation de concentres de plasma riche en plaquettes
US7866485B2 (en)	2005-02-07	2011-01-11	Hanuman, Llc	Apparatus and method for preparing platelet rich plasma and concentrates thereof
US8567609B2 (en)	2006-05-25	2013-10-29	Biomet Biologics, Llc	Apparatus and method for separating and concentrating fluids containing multiple components
WO2008127639A1 (fr)	2007-04-12	2008-10-23	Biomet Biologics, Llc	Système de fractionnement de suspension à flotteur
US8328024B2 (en)	2007-04-12	2012-12-11	Hanuman, Llc	Buoy suspension fractionation system
EP2620139B1 (fr)	2008-02-27	2016-07-20	Biomet Biologics, LLC	Solutions riches d'un antagoniste du récepteur de l'interleukine-1
WO2009111338A1 (fr)	2008-02-29	2009-09-11	Biomet Manufacturing Corp.	Système et procédé pour la séparation d'une matière
US8012077B2 (en)	2008-05-23	2011-09-06	Biomet Biologics, Llc	Blood separating device
US8187475B2 (en)	2009-03-06	2012-05-29	Biomet Biologics, Llc	Method and apparatus for producing autologous thrombin
US8313954B2 (en)	2009-04-03	2012-11-20	Biomet Biologics, Llc	All-in-one means of separating blood components
US9011800B2 (en)	2009-07-16	2015-04-21	Biomet Biologics, Llc	Method and apparatus for separating biological materials
US8591391B2 (en)	2010-04-12	2013-11-26	Biomet Biologics, Llc	Method and apparatus for separating a material
PT2739270T (pt)	2011-08-01	2020-04-02	Hb Biotechnologies Corp	Cápsulas não digestíveis para a distribuição de materiais absorventes de fluido
US9642956B2 (en)	2012-08-27	2017-05-09	Biomet Biologics, Llc	Apparatus and method for separating and concentrating fluids containing multiple components
US20140271589A1 (en)	2013-03-15	2014-09-18	Biomet Biologics, Llc	Treatment of collagen defects using protein solutions
US9895418B2 (en)	2013-03-15	2018-02-20	Biomet Biologics, Llc	Treatment of peripheral vascular disease using protein solutions
US9950035B2 (en)	2013-03-15	2018-04-24	Biomet Biologics, Llc	Methods and non-immunogenic compositions for treating inflammatory disorders
US10143725B2 (en)	2013-03-15	2018-12-04	Biomet Biologics, Llc	Treatment of pain using protein solutions
US10208095B2 (en)	2013-03-15	2019-02-19	Biomet Manufacturing, Llc	Methods for making cytokine compositions from tissues using non-centrifugal methods
US9713810B2 (en)	2015-03-30	2017-07-25	Biomet Biologics, Llc	Cell washing plunger using centrifugal force
US9757721B2 (en)	2015-05-11	2017-09-12	Biomet Biologics, Llc	Cell washing plunger using centrifugal force

1958
- 1958-03-13 SE SE245258A patent/SE169293C1/xx unknown
1959
- 1959-01-19 GB GB188359A patent/GB854715A/en not_active Expired
- 1959-03-10 BE BE576522A patent/BE576522A/fr unknown
- 1959-03-12 CH CH7074659A patent/CH413811A/de unknown
- 1959-03-12 DE DE19591418013 patent/DE1418013A1/de active Pending

Also Published As

Publication number	Publication date
GB854715A (en)	1960-11-23
BE576522A (fr)	1959-09-10
SE169293C1 (fr)	1959-11-10
DE1418013A1 (de)	1968-10-17

Publication	Publication Date	Title
CH413811A (de)	1966-05-31	Verfahren zur Herstellung von hydrophilen Erzeugnissen von hohem Molekulargewicht aus Dextransubstanzen
DE3645226C2 (fr)	1993-07-15
EP0048323B1 (fr)	1985-04-24	Produit sous forme de poudre pour le traitement de blessures; son procédé de préparation
DE2653135C2 (fr)	1988-12-01
DE4318094B4 (de)	2004-03-04	Superabsorbentien, Verfahren zu ihrer Herstellung sowie ihre Verwendung
DE60005932T2 (de)	2004-08-12	Nanopartikel auf der basis von biopolymer
DE2358150C2 (de)	1982-03-18	Verfahren zum Herstellen von Wasser aufnehmenden, aber darin zu mehr als 50% unlöslichen Celluloseethern
DE69527370T2 (de)	2002-12-12	Chitosan-salze und verfahren zu deren herstellung
DE2627125C2 (de)	1985-12-12	Hydrophiles Pullulangel und Verfahren zu seiner Herstellung
EP0119420B1 (fr)	1987-01-14	Polyméres cyclodextrines gonflant vite et fortement dans l'eau, leur procédé de fabrication et leur emploi comme agent de désintégration dans la préparation de comprimés
EP0324985A2 (fr)	1989-07-26	Procédé de préparation de polymères greffés de polysaccharide absorbant l'eau et gonflables dans l'eau
DE1720955B2 (de)	1978-04-27	Verfahren zur Herstellung eines polymeren Formgegenstands mit gegenüber Proteinen reaktionsfähigen Gruppen auf seiner Oberfläche
DE2840011A1 (de)	1979-06-21	Polysaccharidderivate und verfahren zu deren herstellung
DE69223587T2 (de)	1998-07-23	Carboxyalkylpolysaccharide und Verfahren zu ihrer Herstellung
EP0483485A1 (fr)	1992-05-06	Procédé de préparation de petites particules de polysaccaride greffés gonflables par l'eau
DE1443396C3 (de)	1975-01-23	Verfahren zur Herstellung von hochmolekularen, ionenaustauschende Gruppen enthaltenden, hydrophilen Vernetzungsprodukten
NO131007B (fr)	1974-12-09
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