CH428737A - Verfahren zur Herstellung von 2-Hydroxybenzopyridocolinderivaten und deren Säureanlagerungssalzen - Google Patents

Verfahren zur Herstellung von 2-Hydroxybenzopyridocolinderivaten und deren Säureanlagerungssalzen

Info

Publication number: CH428737A
Authority: CH; Switzerland
Prior art keywords: benzopyridocoline; group; hexahydro; axial; carbon atoms
Prior art date: 1961-08-29

Application number

CH682762A

Other languages

German (de)

English (en)

Inventor

Ray Tretter James

Original Assignee

Pfizer & Co C

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1961-08-29

Filing date

1962-06-06

Publication date

1967-01-31

1962-06-06 Application filed by Pfizer & Co C filed Critical Pfizer & Co C

1967-01-31 Publication of CH428737A publication Critical patent/CH428737A/de

Links

238000000034 method Methods 0.000 title claims description 57
238000002360 preparation method Methods 0.000 title claims description 40
230000008569 process Effects 0.000 title claims description 27
150000003839 salts Chemical class 0.000 title claims description 25
239000002253 acid Substances 0.000 title claims description 21
229910052757 nitrogen Inorganic materials 0.000 claims description 80
-1 methylenedioxy group Chemical group 0.000 claims description 70
238000006243 chemical reaction Methods 0.000 claims description 42
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 28
125000000217 alkyl group Chemical group 0.000 claims description 23
125000004432 carbon atom Chemical group C* 0.000 claims description 17
239000003795 chemical substances by application Substances 0.000 claims description 17
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125000003545 alkoxy group Chemical group 0.000 claims description 9
150000002148 esters Chemical class 0.000 claims description 6
239000001257 hydrogen Substances 0.000 claims description 6
229910052739 hydrogen Inorganic materials 0.000 claims description 6
239000000376 reactant Substances 0.000 claims description 6
125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims description 5
125000005336 allyloxy group Chemical group 0.000 claims description 5
125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims description 5
125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims description 5
125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims description 5
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 5
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WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 description 4
OISVCGZHLKNMSJ-UHFFFAOYSA-N 2,6-dimethylpyridine Chemical compound CC1=CC=CC(C)=N1 OISVCGZHLKNMSJ-UHFFFAOYSA-N 0.000 description 4
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150000004945 aromatic hydrocarbons Chemical class 0.000 description 4
238000009835 boiling Methods 0.000 description 4
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150000001983 dialkylethers Chemical class 0.000 description 4
HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 description 4
230000000694 effects Effects 0.000 description 4
FKRCODPIKNYEAC-UHFFFAOYSA-N ethyl propionate Chemical compound CCOC(=O)CC FKRCODPIKNYEAC-UHFFFAOYSA-N 0.000 description 4
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239000007788 liquid Substances 0.000 description 4
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KXWLFPPSOCSXPZ-UHFFFAOYSA-N 7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinoline Chemical compound C1CN=CC2=C1C=C1OCOC1=C2 KXWLFPPSOCSXPZ-UHFFFAOYSA-N 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CH682762A 1961-08-29 1962-06-06 Verfahren zur Herstellung von 2-Hydroxybenzopyridocolinderivaten und deren Säureanlagerungssalzen CH428737A (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US13376061A	1961-08-29	1961-08-29
US13618661A	1961-09-06	1961-09-06

Publications (1)

Publication Number	Publication Date
CH428737A true CH428737A (de)	1967-01-31

Family

ID=26831677

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CH682762A CH428737A (de)	1961-08-29	1962-06-06	Verfahren zur Herstellung von 2-Hydroxybenzopyridocolinderivaten und deren Säureanlagerungssalzen

Country Status (7)

Country	Link
BE (1)	BE618741A (fr)
CH (1)	CH428737A (fr)
DE (1)	DE1303628C2 (fr)
DK (1)	DK122391B (fr)
FI (1)	FI49422C (fr)
NL (1)	NL143224B (fr)
SE (1)	SE308314B (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU175890B (en) *	1977-06-15	1980-11-28	Chinoin Gyogyszer Es Vegyeszet	Process for producing new 1,2,3,4,6,7-hexahydro-11-b-alpha-benzo-square bracket-a-square brecket closed-quinolyzine derivatives

1962
- 1962-05-29 FI FI107362A patent/FI49422C/fi active
- 1962-05-30 DE DE19621303628D patent/DE1303628C2/de not_active Expired
- 1962-05-30 SE SE614262A patent/SE308314B/xx unknown
- 1962-06-01 NL NL279180A patent/NL143224B/xx not_active IP Right Cessation
- 1962-06-01 DK DK245462A patent/DK122391B/da unknown
- 1962-06-06 CH CH682762A patent/CH428737A/de unknown
- 1962-06-08 BE BE618741A patent/BE618741A/fr unknown

Also Published As

Publication number	Publication date
BE618741A (fr)	1962-12-14
SE308314B (fr)	1969-02-10
FI49422C (fi)	1975-06-10
FI49422B (fr)	1975-02-28
NL143224B (nl)	1974-09-16
DK122391B (da)	1972-02-28
DE1303628B (fr)	1973-03-22
DE1303628C2 (de)	1973-10-18

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DE3320028C2 (fr)	1988-06-23
DE2520131C3 (de)	1981-07-30	1,1,-Disubstituierte Octahydro-indolo[2,3-a]chinolizine und verfahren zu deren Herstellung
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DE19932314A1 (de)	2001-01-11	Benzofuranderivate
DE3204074C2 (fr)	1987-12-23
DE1695623C3 (de)	1978-06-01	Verfahren zur Herstellung racemischer oder optisch aktiver 6H.7H - cis-7- Aminodesacetyleephalosporansäure-Derivate
DE1967030C3 (de)	1978-08-03	γ-Lactame der 6H,7H-cis-7- Amino-3aminomethyl-ceph-3-em-4-carbonsäuren
EP0035244B1 (fr)	1985-05-08	Cycloalca(4,5)pyrrolo(2,3-g)isoquinoléines, procédés et intermédiaires pour leur préparation, et médicaments les contenant
EP0054672A1 (fr)	1982-06-30	Composés du type lactame, compositions pharmaceutiques les contenant et procédé de préparation de ces composés et compositions pharmaceutiques
WO1983002775A1 (fr)	1983-08-18	Alcaloides d'ergot de seigle, leur procede de fabrication et preparations pharmaceutiques les contenant
DE3109532C2 (de)	1986-01-30	Stereoisomere 1,4;3,6-Dianhydro-2,5-diazido-2,5-didesoxyhexite, Verfahren zur Herstellung derselben und diese Verbindungen enthaltende Arzneimittel
DE2950436A1 (de)	1980-07-10	1 alpha -aethyl-1 beta - eckige klammer auf 2'-(methoxycarbonyl)-aethyl eckige klammer zu -9-brom-1,2,3,4,6,7,12,12b -octahydroindolo eckige klammer auf 2,3-a eckige klammer zu chinolizinderivate, verfahren zur herstellung derselben bzw. von 10-bromvincamin und 10-brom-14-epivincamin, erstere enthaltende arzneimittel sowie 1-aethyl-1- eckige klammer auf 2'- (acetoxy)-2'-(methoxycarbonyl)-aethyl eckige klammer zu -9-brom-1,2,3,4,6,7- hexahydro-12h-indolo eckige klammer auf 2,3-a eckige klammer zu chinolizin-5- iumperchlorat und 1-aethyl-1- eckige klammer auf 2'-(hydroxy)-2'-(methoxycarbonyl)- aethyl eckige klammer zu -9-brom-1,2,3,4, 6,7-hexahydro-12h-indolo eckige klammer auf 2,3-a eckige klammer zu chinolizin- 5-iumperchlorat
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