CH457435A - Process for the preparation of esters of 3-indole-aliphatic acids - Google Patents

Process for the preparation of esters of 3-indole-aliphatic acids

Info

Publication number: CH457435A
Authority: CH; Switzerland
Prior art keywords: indole; esters; preparation; aliphatic acids; aliphatic
Prior art date: 1963-02-01

Application number

CH236068A

Other languages

German (de)

Inventor

Gal George

Sletzinger Meyer

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1963-02-01

Filing date

1964-01-31

Publication date

1968-06-15

1964-01-31 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

1968-06-15 Publication of CH457435A publication Critical patent/CH457435A/en

Links

150000002148 esters Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
- C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/36—Oxygen atoms in position 3, e.g. adrenochrome

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Indole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Enzymes And Modification Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CH236068A 1963-02-01 1964-01-31 Process for the preparation of esters of 3-indole-aliphatic acids CH457435A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US25564263A	1963-02-01	1963-02-01

Publications (1)

Publication Number	Publication Date
CH457435A true CH457435A (en)	1968-06-15

Family

ID=22969254

Family Applications (16)

Application Number	Title	Priority Date	Filing Date
CH444166A CH466285A (en)	1963-02-01	1964-01-31	Process for the preparation of 1-acyl-3-indolyl-acetic acid or its esters
CH236068A CH457435A (en)	1963-02-01	1964-01-31	Process for the preparation of esters of 3-indole-aliphatic acids
CH1674768A CH466290A (en)	1963-02-01	1964-01-31	Process for the preparation of 1-acyl-indolyl-aliphatic acids
CH236268A CH557815A (en)	1963-02-01	1964-01-31	Alpha- 1-acyl-3-indolyl aliphatic acid derivs
CH490268A CH466286A (en)	1963-02-01	1964-01-31	Process for the preparation of 1-acyl-3-indolyl-aliphatic acids
CH1674468A CH466288A (en)	1963-02-01	1964-01-31	Process for the preparation of 3-indolyl-lower aliphatic acids
CH236368A CH457436A (en)	1963-02-01	1964-01-31	Process for the preparation of esters of 3-indolyl-lower aliphatic acids
CH236568A CH464203A (en)	1963-02-01	1964-01-31	Process for the preparation of 1-acyl-3-indolyl-aliphatic acids or their t-butyl esters
CH236468A CH466283A (en)	1963-02-01	1964-01-31	Process for the preparation of 3-indolyl-aliphatic acids
CH236168A CH464202A (en)	1963-02-01	1964-01-31	Process for the production of 3-indole-lower aliphatic acids
CH490368A CH466287A (en)	1963-02-01	1964-01-31	Process for the preparation of 3-indolyl-lower aliphatic acids
CH419468A CH466284A (en)	1963-02-01	1964-01-31	Process for the preparation of 3-indolyl-lower aliphatic acids
CH1674568A CH466289A (en)	1963-02-01	1964-01-31	Process for the preparation of 1-alcyl-3-indolyl-aliphatic acids
CH236668A CH457437A (en)	1963-02-01	1964-01-31	Process for the preparation of 3-indolyl-lower aliphatic acids
CH235868A CH457434A (en)	1963-02-01	1964-01-31	Process for the preparation of the t-butyl ester of 3-indole-lower aliphatic acids
CH115364A CH489495A (en)	1963-02-01	1967-02-23	Process for the preparation of 3-indolyl-lower aliphatic acids

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
CH444166A CH466285A (en)	1963-02-01	1964-01-31	Process for the preparation of 1-acyl-3-indolyl-acetic acid or its esters

Family Applications After (14)

Application Number	Title	Priority Date	Filing Date
CH1674768A CH466290A (en)	1963-02-01	1964-01-31	Process for the preparation of 1-acyl-indolyl-aliphatic acids
CH236268A CH557815A (en)	1963-02-01	1964-01-31	Alpha- 1-acyl-3-indolyl aliphatic acid derivs
CH490268A CH466286A (en)	1963-02-01	1964-01-31	Process for the preparation of 1-acyl-3-indolyl-aliphatic acids
CH1674468A CH466288A (en)	1963-02-01	1964-01-31	Process for the preparation of 3-indolyl-lower aliphatic acids
CH236368A CH457436A (en)	1963-02-01	1964-01-31	Process for the preparation of esters of 3-indolyl-lower aliphatic acids
CH236568A CH464203A (en)	1963-02-01	1964-01-31	Process for the preparation of 1-acyl-3-indolyl-aliphatic acids or their t-butyl esters
CH236468A CH466283A (en)	1963-02-01	1964-01-31	Process for the preparation of 3-indolyl-aliphatic acids
CH236168A CH464202A (en)	1963-02-01	1964-01-31	Process for the production of 3-indole-lower aliphatic acids
CH490368A CH466287A (en)	1963-02-01	1964-01-31	Process for the preparation of 3-indolyl-lower aliphatic acids
CH419468A CH466284A (en)	1963-02-01	1964-01-31	Process for the preparation of 3-indolyl-lower aliphatic acids
CH1674568A CH466289A (en)	1963-02-01	1964-01-31	Process for the preparation of 1-alcyl-3-indolyl-aliphatic acids
CH236668A CH457437A (en)	1963-02-01	1964-01-31	Process for the preparation of 3-indolyl-lower aliphatic acids
CH235868A CH457434A (en)	1963-02-01	1964-01-31	Process for the preparation of the t-butyl ester of 3-indole-lower aliphatic acids
CH115364A CH489495A (en)	1963-02-01	1967-02-23	Process for the preparation of 3-indolyl-lower aliphatic acids

Country Status (11)

Country	Link
AT (1)	AT277992B (en)
BE (1)	BE643268A (en)
BR (1)	BR6456479D0 (en)
CH (16)	CH466285A (en)
DE (16)	DE1695492A1 (en)
DK (11)	DK109562C (en)
FI (9)	FI46955C (en)
FR (1)	FR1559559A (en)
GB (13)	GB1050738A (en)
NL (1)	NL6400813A (en)
SE (12)	SE302463B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU163233B (en) *	1970-07-31	1973-07-28
ES2034510T5 (en) *	1988-06-21	2003-01-16	Rauter Vita Zahnfabrik	DISPERSED CERAMIC MASS.
GB9518994D0 (en) *	1995-09-16	1995-11-15	Agrevo Uk Ltd	Fungicides

0
- GB GB1050734D patent/GB1050734A/en active Active
- GB GB1050739D patent/GB1050739A/en active Active
- GB GB1050729D patent/GB1050729A/en active Active
- GB GB1050740D patent/GB1050740A/en active Active
- GB GB1050736D patent/GB1050736A/en active Active
- GB GB1050733D patent/GB1050733A/en active Active
- GB GB1050735D patent/GB1050735A/en active Active
- GB GB1050731D patent/GB1050731A/en active Active
- GB GB1050737D patent/GB1050737A/en active Active
- GB GB1050730D patent/GB1050730A/en active Active
- GB GB1050728D patent/GB1050728A/en active Active
- GB GB1050732D patent/GB1050732A/en active Active
- GB GB1050738D patent/GB1050738A/en active Active
1964
- 1964-01-14 DE DE19641695492 patent/DE1695492A1/en active Pending
- 1964-01-24 DE DE19641695493 patent/DE1695493A1/en active Pending
- 1964-01-24 DE DE19641695491 patent/DE1695491A1/en active Pending
- 1964-01-24 DE DE19641695485 patent/DE1695485A1/en active Pending
- 1964-01-24 DE DE19641695488 patent/DE1695488A1/en active Pending
- 1964-01-24 DE DE19641695489 patent/DE1695489A1/en active Pending
- 1964-01-24 DE DE19641770134 patent/DE1770134A1/en active Pending
- 1964-01-24 DE DE19641770132 patent/DE1770132A1/en active Pending
- 1964-01-24 DE DE19641793561 patent/DE1793561A1/en active Pending
- 1964-01-24 DE DE19641695484 patent/DE1695484A1/en active Pending
- 1964-01-24 DE DE19641470059D patent/DE1470059B1/en active Pending
- 1964-01-24 DE DE19641695490 patent/DE1695490A1/en active Pending
- 1964-01-24 DE DE19641695487 patent/DE1695487A1/en active Pending
- 1964-01-24 DE DE19641770802 patent/DE1770802A1/en active Pending
- 1964-01-24 DE DE19641770116 patent/DE1770116A1/en active Pending
- 1964-01-24 DE DE19641695486 patent/DE1695486A1/en active Pending
- 1964-01-28 BR BR15647964A patent/BR6456479D0/en unknown
- 1964-01-28 AT AT01821/67A patent/AT277992B/en not_active IP Right Cessation
- 1964-01-29 FI FI16964A patent/FI46955C/en active
- 1964-01-31 DK DK598265A patent/DK109562C/en active
- 1964-01-31 CH CH444166A patent/CH466285A/en unknown
- 1964-01-31 CH CH236068A patent/CH457435A/en unknown
- 1964-01-31 CH CH1674768A patent/CH466290A/en unknown
- 1964-01-31 CH CH236268A patent/CH557815A/en not_active IP Right Cessation
- 1964-01-31 DK DK598765A patent/DK109334C/en active
- 1964-01-31 CH CH490268A patent/CH466286A/en unknown
- 1964-01-31 CH CH1674468A patent/CH466288A/en unknown
- 1964-01-31 DK DK48964A patent/DK112238B/en unknown
- 1964-01-31 CH CH236368A patent/CH457436A/en unknown
- 1964-01-31 FR FR1559559D patent/FR1559559A/fr not_active Expired
- 1964-01-31 SE SE89267A patent/SE302463B/xx unknown
- 1964-01-31 BE BE643268D patent/BE643268A/xx unknown
- 1964-01-31 CH CH236568A patent/CH464203A/en unknown
- 1964-01-31 CH CH236468A patent/CH466283A/en unknown
- 1964-01-31 CH CH236168A patent/CH464202A/en unknown
- 1964-01-31 NL NL6400813A patent/NL6400813A/xx unknown
- 1964-01-31 CH CH490368A patent/CH466287A/en unknown
- 1964-01-31 SE SE88967A patent/SE317975B/xx unknown
- 1964-01-31 CH CH419468A patent/CH466284A/en unknown
- 1964-01-31 CH CH1674568A patent/CH466289A/en unknown
- 1964-01-31 CH CH236668A patent/CH457437A/en unknown
- 1964-01-31 DK DK598565A patent/DK109514C/en active
- 1964-01-31 SE SE123764A patent/SE307948B/xx unknown
- 1964-01-31 CH CH235868A patent/CH457434A/en unknown
1965
- 1965-11-22 DK DK598665A patent/DK112239B/en unknown
- 1965-11-22 DK DK598465A patent/DK111751B/en unknown
- 1965-11-22 DK DK598965A patent/DK112314B/en unknown
- 1965-11-22 DK DK598865A patent/DK112313B/en unknown
- 1965-11-22 DK DK598365A patent/DK113501B/en unknown
1966
- 1966-02-23 DK DK93266A patent/DK112446B/en unknown
- 1966-02-23 DK DK93366A patent/DK112447B/en unknown
1967
- 1967-01-20 SE SE891/67A patent/SE304995B/xx unknown
- 1967-01-20 SE SE89367A patent/SE302133B/en unknown
- 1967-01-20 SE SE88867A patent/SE302132B/en unknown
- 1967-01-20 SE SE895/67A patent/SE320069B/xx unknown
- 1967-01-20 SE SE890/67A patent/SE307133B/xx unknown
- 1967-01-20 SE SE894/67A patent/SE320367B/xx unknown
- 1967-01-20 SE SE88667A patent/SE302130B/en unknown
- 1967-01-20 SE SE896/67A patent/SE320666B/xx unknown
- 1967-01-31 SE SE88767A patent/SE302131B/xx unknown
- 1967-02-23 CH CH115364A patent/CH489495A/en not_active IP Right Cessation
1970
- 1970-09-21 FI FI257270A patent/FI47099C/en active
- 1970-09-21 FI FI257470A patent/FI47100C/en active
- 1970-09-21 FI FI257070A patent/FI47097B/fi active
- 1970-09-21 FI FI257370A patent/FI47185C/en active
- 1970-09-21 FI FI257570A patent/FI47101C/en active
- 1970-09-21 FI FI257170A patent/FI47098C/en active
- 1970-09-21 FI FI256870A patent/FI47096C/en active
- 1970-09-21 FI FI702570A patent/FI47097C/en active

Also Published As

Publication number	Publication date
CH489495A (en)	1970-04-30
FI47098B (en)	1973-05-31
FI47096B (en)	1973-05-31
FR1559559A (en)	1969-03-14
FI47100B (en)	1973-05-31
CH466285A (en)	1968-12-15
DE1770132A1 (en)	1971-09-30
DK112239B (en)	1968-11-25
DE1695488A1 (en)	1970-09-17
FI47097B (en)	1973-05-31
BE643268A (en)	1964-07-31
CH464202A (en)	1968-10-31
GB1050728A (en)
FI47101C (en)	1973-09-10
DE1695485A1 (en)	1971-04-15
SE304995B (en)	1968-10-14
FI47099B (en)	1973-05-31
FI47099C (en)	1973-09-10
DK109562C (en)	1968-05-13
CH464203A (en)	1968-10-31
CH457434A (en)	1968-06-15
DK112238B (en)	1968-11-25
DE1695492A1 (en)	1971-04-01
GB1050731A (en)
CH466283A (en)	1968-12-15
DE1695491A1 (en)	1971-04-15
GB1050735A (en)
DK109334C (en)	1968-04-16
FI46955C (en)	1973-08-10
FI47185C (en)	1973-10-10
SE307948B (en)	1969-01-27
DK109514C (en)	1968-05-06
DK112447B (en)	1968-12-16
GB1050739A (en)
CH466284A (en)	1968-12-15
GB1050732A (en)
GB1050730A (en)
CH557815A (en)	1975-01-15
SE302133B (en)	1968-07-08
CH466287A (en)	1968-12-15
FI46955B (en)	1973-05-02
SE320069B (en)	1970-02-02
DK111751B (en)	1968-10-07
GB1050738A (en)
CH466288A (en)	1968-12-15
SE307133B (en)	1968-12-23
SE302130B (en)	1968-07-08
DK112313B (en)	1968-12-02
DE1695484A1 (en)	1971-04-15
CH466286A (en)	1968-12-15
SE317975B (en)	1969-12-01
SE302131B (en)	1968-07-08
DE1770134A1 (en)	1971-09-30
SE320367B (en)	1970-02-09
DE1695487A1 (en)	1970-10-01
DK112314B (en)	1968-12-02
DE1695489A1 (en)	1970-08-13
DE1695486A1 (en)	1971-04-15
GB1050734A (en)
DE1793561A1 (en)	1972-01-20
AT277992B (en)	1970-01-12
GB1050736A (en)
FI47097C (en)	1973-09-10
GB1050729A (en)
FI47100C (en)	1973-09-10
GB1050740A (en)
FI47185B (en)	1973-07-02
CH466290A (en)	1968-12-15
GB1050737A (en)
FI47101B (en)	1973-05-31
SE302132B (en)	1968-07-08
GB1050733A (en)
BR6456479D0 (en)	1973-09-20
DE1695493A1 (en)	1971-04-01
SE302463B (en)	1968-07-22
FI47098C (en)	1973-09-10
CH466289A (en)	1968-12-15
DE1770116A1 (en)	1971-10-14
DK112446B (en)	1968-12-16
CH457436A (en)	1968-06-15
DE1770802A1 (en)	1972-02-17
DE1470059B1 (en)	1970-01-29
CH457437A (en)	1968-06-15
NL6400813A (en)	1964-08-03
FI47096C (en)	1973-09-10
DE1695490A1 (en)	1971-04-15
SE320666B (en)	1970-02-16
DK113501B (en)	1969-03-31

Publication	Publication Date	Title
AT256791B (en)	1967-09-11	Process for the preparation of esters
AT253491B (en)	1967-04-10	Process for the preparation of esters
CH462185A (en)	1968-09-15	Process for the preparation of esters of phosphoric acids
AT267509B (en)	1969-01-10	Process for the preparation of esters
CH432548A (en)	1967-03-31	Process for the preparation of coumaranyl-N-methyl-carbamic acid esters
AT244936B (en)	1966-02-10	Process for the preparation of pure aryl esters of di- and polycarboxylic acids
CH432498A (en)	1967-03-31	Process for the preparation of hydroxyphenyl-substituted esters
CH472435A (en)	1969-05-15	Process for the preparation of esters of phosphoric acids
AT253480B (en)	1967-04-10	Process for the preparation of esters of unsaturated aliphatic carboxylic acids
CH479565A (en)	1969-10-15	Process for the preparation of esters of 3B-hydroxy 4-steroids
CH448122A (en)	1967-12-15	Process for the preparation of esters
CH459183A (en)	1968-07-15	Process for the preparation of phosphorus-containing esters
CH436262A (en)	1967-05-31	Process for the preparation of arylsulfonylethylthiosulfuric acids
CH457436A (en)	1968-06-15	Process for the preparation of esters of 3-indolyl-lower aliphatic acids
CH435238A (en)	1967-05-15	Process for the preparation of carboxylic acid esters
CH459988A (en)	1968-07-31	Process for the preparation of esters of thio-carboxylic acids
AT246723B (en)	1966-05-10	Process for the preparation of sulfamylanthranilic acids
CH454134A (en)	1968-04-15	Process for the preparation of esters of 1a-methyl-2-5a-androsten-17B-ols
CH405263A (en)	1966-01-15	Process for the preparation of esters of higher monocarboxylic acids
AT243263B (en)	1965-11-10	Process for the preparation of new esters of p-acetaminophenol
CH442284A (en)	1967-08-31	Process for the preparation of N-nortricyclylcarbamic acid esters
CH449630A (en)	1968-01-15	Process for the preparation of imidazolene carboxylic acids
CH457431A (en)	1968-06-15	Process for the preparation of indolyl-lower aliphatic acids
CH468379A (en)	1969-02-15	Process for the preparation of esters of indolyl-3-acetic acids
CH535250A (en)	1973-03-31	Process for the preparation of esters of oxazolyl-alkanoic acids